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5188 publications

PubMed DOI Crossref
Persistent immunosuppressive effects of dibutyl phthalate exposure in adult male mice.
Pierozan P, Källsten L, Theodoropoulou E, Almamoun R, Karlsson O
Sci. Total Environ. 878 (-) 162741 [2023-06-20; online 2023-03-11]
Oskar Karlsson SciLifeLab Fellow
DOI Crossref
Ribosome clustering and surface layer reorganization in the microsporidian host-invasion apparatus
Sharma H, Jespersen N, Ehrenbolger K, Carlson LA, Barandun J
- - (-) - [2023-06-04; online 2023-06-04]
Jonas Barandun SciLifeLab Fellow
PubMed DOI Crossref
A survey of mapping algorithms in the long-reads era.
Sahlin K, Baudeau T, Cazaux B, Marchet C
Genome Biol. 24 (1) 133 [2023-06-01; online 2023-06-01]
Kristoffer Sahlin SciLifeLab Fellow
Efficient Resource Scheduling for Distributed Infrastructures using Negotiation Capabilities
Chu J, Singh PS, Toor S
IEEE CLOUD 2023 - (-) - [2023-05-29]
Prashant Singh SciLifeLab Fellow
PubMed DOI Crossref
Entropy predicts sensitivity of pseudo-random seeds.
Maier BD, Sahlin K
Genome Res - (-) - [2023-05-22; online 2023-05-22]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Design of Drug Efficacy Guided by Free Energy Simulations of the β2 -Adrenoceptor.
Panel N, Vo DD, Kahlous NA, ..., Gmeiner P, Carlsson J
Angew. Chem. Int. Ed. Engl. 62 (22) e202218959 [2023-05-22; online 2023-04-20]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Atlas of mRNA translation and decay for bacteria.
Huch S, Nersisyan L, Ropat M, ..., Engstrand L, Pelechano V
Nat. Microbiol - (-) - [2023-05-22; online 2023-05-22]
SciLifeLab Fellow Vicent Pelechano
PubMed DOI Crossref
Membranes in focus.
Sezgin E, Levental I
Biophys. J. - (-) - [2023-05-19; online 2023-05-19]
Erdinc Sezgin SciLifeLab Fellow
DOI Crossref
Striking allelic diversity despite structural homogeneity of ace-1 duplications in Anopheles mosquitoes
Claret JL, Di-Liegro M, Namias A, ..., Milesi P, Labbé P
- - (-) - [2023-05-12; online 2023-05-12]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
The oxDNA Coarse-Grained Model as a Tool to Simulate DNA Origami.
Doye JPK, Fowler H, Prešern D, ..., Poppleton E, Snodin BEK
Methods in molecular biology (Clifton, N.J.) 2639 (-) 93-112 [2023-05-11; online 2023-05-11]
Erik Benson SciLifeLab Fellow
PubMed DOI Crossref
Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures.
Lin W, García FR, Norin EL, ..., Du J, Globisch D
Chem. Commun. (Camb.) 59 (39) 5843-5846 [2023-05-11; online 2023-05-11]
Daniel Globisch SciLifeLab Fellow
PubMed DOI Crossref
A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens.
Schlegel J, Porebski B, Andronico L, ..., Fernandez-Capetillo O, Sezgin E
Nano Lett. 23 (9) 3701-3707 [2023-05-10; online 2023-03-09]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies.
Young AL, Vogel JW, Robinson JL, ..., Lee EB, Hansson O
Brain - (-) - [2023-05-08; online 2023-05-08]
Jacob W Vogel
PubMed DOI Crossref
Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.
Leuzy A, Binette AP, Vogel JW, ..., Hansson O, Alzheimer’s Disease Neuroimaging Initiative
JAMA Neurol - (-) - [2023-05-08; online 2023-05-08]
Jacob W Vogel
PubMed DOI Crossref
Nontarget Analysis of Polluted Surface Waters in Bangladesh Using Open Science Workflows.
Bonnefille B, Karlsson O, Rian MB, ..., Islam MS, Martin JW
Environ. Sci. Technol. 57 (17) 6808-6824 [2023-05-02; online 2023-04-21]
Oskar Karlsson SciLifeLab Fellow
DOI Crossref
Adrenomedullin promotes interneuron migration in a dual human model for hypoxic interneuronopathy of prematurity
Michno WP, Puno A, Li L, ..., Willsey AJ, Pasca AM
- - (-) - [2023-05-01; online 2023-05-01]
SciLifeLab Fellow Wojciech Michno
PubMed DOI Crossref
Intrinsic lipolysis rate for systematic design of lipid-based formulations
Jacobsen AC, Kabedev A, Sinko PD, ..., Bergström CAS, Teleki A
Drug Deliv. and Transl. Res. 13 (5) 1288-1304 [2023-05-00; online 2022-10-08]
Alexandra Teleki SciLifeLab Fellow
PubMed DOI Crossref
Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study.
Dubol M, Immenschuh J, Jonasson M, ..., Sundström-Poromaa I, Comasco E
Compr Psychiatry 123 (-) 152381 [2023-05-00; online 2023-03-05]
Erika Comasco SciLifeLab Fellow
PubMed DOI Crossref
Reconfigurable self-assembled DNA devices.
Benson E, Bath J
Sci Robot 8 (77) eadh8148 [2023-04-26; online 2023-04-26]
Erik Benson SciLifeLab Fellow
PubMed DOI Crossref
Development of top-down cortical propagations in youth.
Pines A, Keller AS, Larsen B, ..., Fair DA, Satterthwaite TD
Neuron 111 (8) 1316-1330.e5 [2023-04-19; online 2023-02-17]
Jacob W Vogel
PubMed DOI Crossref
Monitoring beta cell survival after intrahepatic islet transplantation using dynamic exendin PET imaging: a proof-of-concept study in individuals with type 1 diabetes.
Jansen TJP, Buitinga M, Boss M, ..., de Koning EJP, Gotthardt M
Diabetes - (-) - [2023-04-17; online 2023-04-17]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
Microscopy-based phenotypic monitoring of MDA-MB-231 spheroids allows the evaluation of phenotype-directed therapy.
Mahmoud L, Cougnoux A, Bekiari C, ..., Gsell L, Hausser J
Exp. Cell Res. 425 (2) 113527 [2023-04-15; online 2023-03-06]
Jean Hausser SciLifeLab Fellow
PubMed DOI Crossref
Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids.
Stiernman L, Dubol M, Comasco E, ..., Johansson M, Bixo M
Transl Psychiatry 13 (1) 124 [2023-04-14; online 2023-04-14]
Erika Comasco SciLifeLab Fellow
DOI Crossref
CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the<i>PTEN</i>gene locus mimicking cancer profiles
Geng K, Merino LG, Veiga RG, ..., Brinkman EK, Kutter C
- - (-) - [2023-04-06; online 2023-04-06]
Claudia Kutter SciLifeLab Fellow
PubMed DOI Crossref
Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers.
Nyström N, Prast-Nielsen S, Correia M, ..., Schuppe-Koistinen I, Halfvarson J
J Crohns Colitis 17 (3) 418-432 [2023-04-03; online 2022-10-12]
Daniel Globisch SciLifeLab Fellow
PubMed DOI Crossref
IL-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy.
Tunalı G, Rúbies Bedós M, Nagarajan D, ..., Papakyriacou I, Mao Y
J. Clin. Invest. 133 (7) - [2023-04-03; online 2023-04-03]
SciLifeLab Fellow Yumeng Mao
PubMed DOI Crossref
Voices of the new generation: normalizing career choices outside academia.
Sezgin E
Nat. Rev. Mol. Cell Biol. 24 (4) 237 [2023-04-00; online 2023-01-20]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Gray matter hypoperfusion is a late pathological event in the course of Alzheimer's disease.
Ahmadi K, Pereira JB, Berron D, ..., Mutsaerts HJ, Hansson O
J. Cereb. Blood Flow Metab. 43 (4) 565-580 [2023-04-00; online 2022-11-22]
Jacob W Vogel
PubMed DOI Crossref
Deep mutational scan of a drug efflux pump reveals its structure-function landscape.
Meier G, Thavarasah S, Ehrenbolger K, ..., Barandun J, Seeger MA
Nat. Chem. Biol. 19 (4) 440-450 [2023-04-00; online 2022-11-28]
Jonas Barandun SciLifeLab Fellow
PubMed DOI Crossref
A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken.
Bi H, Tranell J, Harper DC, ..., Globisch D, Andersson L
PLoS Genet 19 (4) e1010724 [2023-04-00; online 2023-04-17]
Daniel Globisch SciLifeLab Fellow
PubMed DOI Crossref
Do lipids tune B cell signaling?
Urbančič I, Eggeling C, Sezgin E
Nat. Chem. Biol. - (-) - [2023-03-30; online 2023-03-30]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis: a population-based colonoscopy study.
Alexandersson BT, Hugerth LW, Hedin C, ..., Andreasson A, Schmidt PT
Scand. J. Gastroenterol. - (-) 1-8 [2023-03-29; online 2023-03-29]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
Linking prokaryotic genome size variation to metabolic potential and environment.
Rodríguez-Gijón A, Buck M, Andersson AF, ..., Nascimento FJA, Garcia SL
ISME Commun 3 (1) 25 [2023-03-27; online 2023-03-27]
Sarahi Garcia SciLifeLab Fellow
PubMed DOI Crossref
Correlative Chemical Imaging and Spatial Chemometrics Delineate Alzheimer Plaque Heterogeneity at High Spatial Resolution.
Wehrli PM, Ge J, Michno W, ..., Blennow K, Hanrieder J
JACS Au 3 (3) 762-774 [2023-03-27; online 2023-03-07]
SciLifeLab Fellow Wojciech Michno
PubMed DOI Crossref
Transcript Isoform Diversity of Ampliconic Genes on the Y Chromosome of Great Apes.
Tomaszkiewicz M, Sahlin K, Medvedev P, Makova KD
bioRxiv - (-) - [2023-03-18; online 2023-03-18]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Phylogenetic Analysis of Allotetraploid Species Using Polarized Genomic Sequences.
Leal JL, Milesi P, Salojärvi J, Lascoux M
Syst. Biol. - (-) - [2023-03-18; online 2023-03-18]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study.
Gudnadottir U, Du J, Hugerth LW, ..., Fransson E, Brusselaers N
BMC Pregnancy Childbirth 23 (1) 153 [2023-03-08; online 2023-03-08]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
Structural basis of mitochondrial membrane bending by the I-II-III2-IV2 supercomplex.
Mühleip A, Flygaard RK, Baradaran R, ..., Sharma V, Amunts A
Nature 615 (7954) 934-938 [2023-03-00; online 2023-03-22]
Alexey Amunts SciLifeLab Fellow
PubMed DOI Crossref
PET Imaging of Neutrophil Elastase with 11C-GW457427 in Acute Respiratory Distress Syndrome in Pigs.
Puuvuori E, Chiodaroli E, Estrada S, ..., Eriksson O, Antoni G
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 64 (3) 423-429 [2023-03-00; online 2022-09-15]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.
Cikes D, Elsayad K, Sezgin E, ..., Banka S, Penninger JM
Nat Metab 5 (3) 495-515 [2023-03-00; online 2023-03-20]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling.
Altea-Manzano P, Doglioni G, Liu Y, ..., Malanchi I, Fendt SM
Nat Cancer 4 (3) 344-364 [2023-03-00; online 2023-02-02]
SciLifeLab Fellow Vicent Pelechano
DOI Crossref
Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during<i>Salmonella</i>gut infection
Gül E, Fattinger SA, Nguyen BD, ..., Sellin ME, Hardt WD
- - (-) - [2023-02-24; online 2023-02-24]
Mikael Sellin SciLifeLab Fellow
PubMed DOI Crossref
Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics.
Jun SH, Toosi H, Mold J, ..., Roth A, Lagergren J
Nat Commun 14 (1) 982 [2023-02-22; online 2023-02-22]
Camilla Engblom SciLifeLab Fellow
PubMed DOI Crossref
Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events.
Allen G, Weiss B, Panasenko OO, ..., Pelechano V, Collart MA
Genome Biol. 24 (1) 30 [2023-02-20; online 2023-02-20]
SciLifeLab Fellow Vicent Pelechano
PubMed DOI Crossref
Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.
Li B, Zeis P, Zhang Y, ..., Steinmetz LM, Pelechano V
Nat Commun 14 (1) 910 [2023-02-17; online 2023-02-17]
SciLifeLab Fellow Vicent Pelechano
PubMed DOI Crossref
An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb.
Choudhury K, Howard RJ, Delemotte L
J. Gen. Physiol. 155 (2) - [2023-02-06; online 2022-12-14]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
Hybridization mediated range expansion and climate change resilience in two conifers
Karunarathne P, Zhou Q, Lascoux M, Milesi P
- - (-) - [2023-02-03; online 2023-02-03]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
[18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44.
Cheung P, Amin MA, Zhang B, ..., Odell LR, Eriksson O
Pharmaceutics 15 (2) - [2023-02-02; online 2023-02-02]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
High-content analysis shows synergistic effects of low perfluorooctanoic acid (PFOS) and perfluorooctane sulfonic acid (PFOA) mixture concentrations on human breast epithelial cell carcinogenesis.
Pierozan P, Kosnik M, Karlsson O
Environ Int 172 (-) 107746 [2023-02-00; online 2023-01-12]
Oskar Karlsson SciLifeLab Fellow
DOI Crossref
Diversity and enrichment of breeding material for resilience in European forests
Olsson S, Dauphin B, Jorge V, ..., Bastien C, Alia R
Forest Ecology and Management 530 (-) 120748 [2023-02-00; online 2023-02-00]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells.
Hsu J, Fatuzzo N, Weng N, ..., Nasca C, Khosla C
J Biol Chem 299 (2) 102848 [2023-02-00; online 2022-12-30]
SciLifeLab Fellow Wojciech Michno
PubMed DOI Crossref
Editorial: Effects of hormonal contraceptives on the brain.
Pletzer B, Comasco E, Hidalgo-Lopez E, Lacreuse A, Derntl B
Front Endocrinol (Lausanne) 14 (-) 1129203 [2023-01-31; online 2023-01-31]
Erika Comasco SciLifeLab Fellow
DOI Crossref
Synchronous effective population size changes and genetic stability of forest trees through glacial cycles
Milesi P, Kastally C, Dauphin B, ..., Pyhäjärvi T, None
- - (-) - [2023-01-06; online 2023-01-06]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with 11C-NES.
Antoni G, Lubberink M, Sörensen J, ..., Skorup P, Lipcsey M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 64 (1) 145-148 [2023-01-00; online 2022-06-09]
Olof Eriksson SciLifeLab Fellow
DOI Crossref
Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
Kaur A, Lin W, Dovhalyuk V, ..., Sellin ME, Globisch D
Chem Sci - (-) - [2023-00-00; online 2023-00-00]
Daniel Globisch SciLifeLab Fellow
PubMed DOI Crossref
Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences.
Velikyan I, Bossart M, Haack T, ..., Wagner M, Eriksson O
Pharmaceuticals (Basel, Switzerland) 16 (1) - [2022-12-31; online 2022-12-31]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
Obesity-Associated Neurodegeneration Pattern Mimics Alzheimer's Disease in an Observational Cohort Study.
Morys F, Potvin O, Zeighami Y, ..., Dagher A, Alzheimer’s Disease Neuroimaging Initiative
J. Alzheimers Dis. 91 (3) 1059-1071 [2022-12-25; online 2022-12-25]
Jacob W Vogel
DOI Crossref
mapquik: Efficient low-divergence mapping of long reads in minimizer space
Ekim B, Sahlin K, Medvedev P, Berger B, Chikhi R
- - (-) - [2022-12-23; online 2022-12-23]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.
Leng H, Zhang H, Li L, ..., Simon AK, Horwood NJ
Nat Commun 13 (1) 7868 [2022-12-22; online 2022-12-22]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Systematic comparison of modeling fidelity levels and parameter inference settings applied to negative feedback gene regulation
Coulier A, Singh P, Sturrock M, Hellander A
PLoS Comput Biol 18 (12) e1010683 [2022-12-15; online 2022-12-15]
Prashant Singh SciLifeLab Fellow
PubMed DOI Crossref
Strobealign: flexible seed size enables ultra-fast and accurate read alignment.
Sahlin K
Genome Biol. 23 (1) 260 [2022-12-15; online 2022-12-15]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth.
Cui Z, Pines AR, Larsen B, ..., Fan Y, Satterthwaite TD
Biol. Psychiatry 92 (12) 973-983 [2022-12-15; online 2022-05-18]
Jacob W Vogel
PubMed DOI Crossref
Madagascar's extraordinary biodiversity: Threats and opportunities.
Ralimanana H, Perrigo AL, Smith RJ, ..., Zizka A, Antonelli A
Science (New York, N.Y.) 378 (6623) eadf1466 [2022-12-02; online 2022-12-02]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Madagascar's extraordinary biodiversity: Evolution, distribution, and use.
Antonelli A, Smith RJ, Perrigo AL, ..., Zizka A, Ralimanana H
Science (New York, N.Y.) 378 (6623) eabf0869 [2022-12-02; online 2022-12-02]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
Grönberg A, Espes D, Carlsson P, Ludvigsson J
BMJ Open Diabetes Res Care - (-) - [2022-12-01; online 2022-11-16]
Daniel Espes SciLifeLab Fellow
DOI Crossref
High-efficiency transfection of<i>Acanthamoeba castellanii</i>using a cationic polymer
Moreno AB, Ek V, Eriksson J, Sellin ME, Guy L
- - (-) - [2022-12-01; online 2022-12-01]
Mikael Sellin SciLifeLab Fellow
PubMed DOI Crossref
Teasing apart the joint effect of demography and natural selection in the birth of a contact zone.
Li L, Milesi P, Tiret M, ..., Wu HX, Lascoux M
New Phytol. 236 (5) 1976-1987 [2022-12-00; online 2022-09-30]
Pascal Milesi SciLifeLab Fellow
DOI Crossref
Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives
Asad S, Jacobsen AC, Teleki A
Current Opinion in Chemical Engineering 38 (-) 100869 [2022-12-00; online 2022-12-00]
Alexandra Teleki SciLifeLab Fellow
PubMed DOI Crossref
How broad is the selfing syndrome? Insights from convergent evolution of gene expression across species and tissues in the Capsella genus.
Zhang Z, Kryvokhyzha D, Orsucci M, ..., Milesi P, Lascoux M
New Phytol. 236 (6) 2344-2357 [2022-12-00; online 2022-09-30]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
Salmonella enterica serovar Cerro displays a phylogenetic structure and genomic features consistent with virulence attenuation and adaptation to cattle.
Cohn AR, Orsi RH, Carroll LM, ..., Wiedmann M, Cheng RA
Front Microbiol 13 (-) 1005215 [2022-11-30; online 2022-11-30]
DDLS Fellow Laura Carroll
DOI Crossref
Gasdermin D is the only Gasdermin that provides non-redundant protection against acute<i>Salmonella</i>gut infection
Fattinger SA, Maurer L, Geiser P, ..., Sellin ME, Hardt WD
- - (-) - [2022-11-25; online 2022-11-25]
Mikael Sellin SciLifeLab Fellow
DOI Crossref
Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue
Engblom C, Thrane K, Lin Q, ..., Lundeberg J, Frisén J
- - (-) - [2022-11-24; online 2022-11-24]
Camilla Engblom SciLifeLab Fellow
PubMed DOI Crossref
CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.
de Thonel A, Ahlskog JK, Daupin K, ..., Sistonen L, Mezger V
Nat Commun 13 (1) 7002 [2022-11-16; online 2022-11-16]
Anniina Vihervaara SciLifeLab Fellow
PubMed DOI Crossref
Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores.
Jespersen N, Ehrenbolger K, Winiger RR, ..., Vossbrinck CR, Barandun J
Nat Commun 13 (1) 6962 [2022-11-15; online 2022-11-15]
Jonas Barandun SciLifeLab Fellow
DOI Crossref
Nanopore sequencing enables multigenic family reconstruction despite highly frequent PCR-induced recombination
Namias A, Sahlin K, Makoundou P, ..., Belkhir K, Weill M
- - (-) - [2022-11-15; online 2022-11-15]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Multi-foci parallelised RESOLFT nanoscopy in an extended field-of-view.
Casas Moreno X, Pennacchietti F, Minet G, ..., Barabas F, Testa I
J Microsc - (-) - [2022-11-14; online 2022-11-14]
Ilaria Testa SciLifeLab Fellow
PubMed DOI Crossref
Genomic trajectories of a near-extinction event in the Chatham Island black robin.
von Seth J, van der Valk T, Lord E, ..., Robertson BC, Dussex N
BMC Genomics 23 (1) 747 [2022-11-10; online 2022-11-10]
DDLS Fellow Tom van der Valk
PubMed DOI Crossref
Super-Resolution Microscopy Opens New Doors to Life at the Nanoscale.
Fuhrmann M, Gockel N, Arizono M, ..., Testa I, Willig KI
J. Neurosci. 42 (45) 8488-8497 [2022-11-09; online 2022-11-10]
Ilaria Testa SciLifeLab Fellow
DOI Crossref
Lineage-specific targets of positive selection in three leaf beetles with different defence capacity against a parasitic wasp
Yang X, Wheat C, Slotte T, Hamback P
- - (-) - [2022-11-04; online 2022-11-04]
SciLifeLab Fellow Tanja Slotte
PubMed DOI Crossref
Grey matter morphology in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.
Kaltsouni E, Dubol M, Wikström J, ..., Sundström-Poromaa I, Comasco E
Eur Neuropsychopharmacol 65 (-) 35-43 [2022-11-04; online 2022-11-04]
Erika Comasco SciLifeLab Fellow
DOI Crossref
Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt
Pellon A, Nasab SDS, Bidkhori G, ..., Shoaie S, Moyes D
- - (-) - [2022-11-01; online 2022-11-01]
Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes.
Espes D, Magnusson L, Caballero-Corbalan J, ..., Casas R, Carlsson PO
BMJ Open Diabetes Res Care 10 (6) - [2022-11-00; online 2022-11-10]
Daniel Espes SciLifeLab Fellow
PubMed DOI Crossref
Curation of BIDS (CuBIDS): A workflow and software package for streamlining reproducible curation of large BIDS datasets.
Covitz S, Tapera TM, Adebimpe A, ..., Cieslak M, Satterthwaite TD
NeuroImage 263 (-) 119609 [2022-11-00; online 2022-09-03]
Jacob W Vogel
PubMed DOI Crossref
Chemical traits of cerebral amyloid angiopathy in familial British-, Danish-, and non-Alzheimer's dementias.
Michno W, Koutarapu S, Camacho R, ..., Lashley T, Hanrieder J
J. Neurochem. 163 (3) 233-246 [2022-11-00; online 2022-09-25]
SciLifeLab Fellow Wojciech Michno
PubMed DOI Crossref
Cohort profile: the Swedish Maternal Microbiome project (SweMaMi) - assessing the dynamic associations between the microbiome and maternal and neonatal adverse events.
Fransson E, Gudnadottir U, Hugerth LW, ..., Brusselaers N, Engstrand L
BMJ Open 12 (10) e065825 [2022-10-26; online 2022-10-26]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
Genomic analyses of the Linum distyly supergene reveal convergent evolution at the molecular level.
Gutiérrez-Valencia J, Fracassetti M, Berdan EL, ..., Arroyo J, Slotte T
Curr. Biol. 32 (20) 4360-4371.e6 [2022-10-24; online 2022-09-09]
SciLifeLab Fellow Tanja Slotte
PubMed DOI Crossref
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5.
Kampen S, Rodríguez D, Jørgensen M, ..., Lebon G, Carlsson J
ACS chemical biology 17 (10) 2744-2752 [2022-10-21; online 2022-09-23]
Jens Carlsson SciLifeLab Fellow
PubMed DOI Crossref
Influence of the extracellular domain size on the dynamic behavior of membrane proteins.
Gurdap CO, Wedemann L, Sych T, Sezgin E
Biophys. J. 121 (20) 3826-3836 [2022-10-18; online 2022-09-14]
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A new framework for detecting copy number variants from single nucleotide polymorphism data: ‘rCNV’, a versatile R package for paralogs and CNVs detection
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Far Red-Shifted CdTe Quantum Dots for Multicolour Stimulated Emission Depletion Nanoscopy.
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Kristina Jonas SciLifeLab Fellow
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Ilaria Testa SciLifeLab Fellow
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Correlative Chemical Imaging Identifies Amyloid Peptide Signatures of Neuritic Plaques and Dystrophy in Human Sporadic Alzheimer's Disease.
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aMeta: an accurate and memory-efficient ancient Metagenomic profiling workflow
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DDLS Fellow Tom van der Valk
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Molecular programming modulates hepatic lipid metabolism and adult metabolic risk in the offspring of obese mothers in a sex-specific manner.
Savva C, Helguero LA, González-Granillo M, ..., Kutter C, Korach-André M
Commun Biol 5 (1) 1057 [2022-10-04; online 2022-10-04]
Claudia Kutter SciLifeLab Fellow
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Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.
Mehregan A, Pérez-Conesa S, Zhuang Y, ..., Ulens C, Delemotte L
Biochim Biophys Acta Biomembr 1864 (10) 183994 [2022-10-01; online 2022-06-18]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Noncoding RNAs and RNA-binding proteins: emerging governors of liver physiology and metabolic diseases.
Sommerauer C, Kutter C
Am. J. Physiol., Cell Physiol. 323 (4) C1003-C1017 [2022-10-01; online 2022-08-15]
Claudia Kutter SciLifeLab Fellow
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Unravelling the Phylogeny of a Common Intestinal Protist: Intrageneric Diversity of Endolimax.
Hocke EF, Jamy M, Burki F, Clark CG, Stensvold CR
Protist 173 (5) 125908 [2022-10-00; online 2022-09-07]
Fabien Burki SciLifeLab Fellow
PubMed DOI Crossref
The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson's Disease.
Romero-Fernandez W, Taura JJ, Crans RAJ, ..., Fuxe K, Borroto-Escuela DO
Mol. Neurobiol. 59 (10) 5955-5969 [2022-10-00; online 2022-07-12]
Jens Carlsson SciLifeLab Fellow
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Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells.
Geng K, Merino LG, Wedemann L, ..., White RJ, Kutter C
Genome Res 32 (10) 1876-1891 [2022-10-00; online 2022-09-30]
Claudia Kutter SciLifeLab Fellow
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Spatiotemporally controlled generation of NTPs for single-molecule studies.
Sabantsev A, Mao G, Aguirre Rivera J, ..., Khodorkovskiy M, Deindl S
Nat. Chem. Biol. 18 (10) 1144-1151 [2022-10-00; online 2022-09-21]
SciLifeLab Fellow Sebastian Deindl
PubMed DOI Crossref
Markov state modelling reveals heterogeneous drug-inhibition mechanism of Calmodulin.
Westerlund AM, Sridhar A, Dahl L, ..., Bodnar AY, Delemotte L
PLoS Comput Biol 18 (10) e1010583 [2022-10-00; online 2022-10-07]
Lucie Delemotte SciLifeLab Fellow
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Global patterns and rates of habitat transitions across the eukaryotic tree of life.
Jamy M, Biwer C, Vaulot D, ..., Massana R, Burki F
Nat Ecol Evol 6 (10) 1458-1470 [2022-10-00; online 2022-08-04]
Fabien Burki SciLifeLab Fellow
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Event-triggered STED imaging.
Alvelid J, Damenti M, Sgattoni C, Testa I
Nat. Methods 19 (10) 1268-1275 [2022-10-00; online 2022-09-08]
Ilaria Testa SciLifeLab Fellow
PubMed DOI Crossref
Elevation and plant species identity jointly shape a diverse arbuscular mycorrhizal fungal community in the High Arctic.
Rasmussen PU, Abrego N, Roslin T, ..., Hugerth LW, Tack AJM
New Phytol. 236 (2) 671-683 [2022-10-00; online 2022-07-15]
DDLS Fellow Luisa Hugerth
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Di-n-Butyl Phthalate and Its Monoester Metabolite Impairs Steroid Hormone Biosynthesis in Human Cells: Mechanistic In Vitro Studies.
Källsten L, Pierozan P, Martin JW, Karlsson O
Cells 11 (19) - [2022-09-27; online 2022-09-27]
Oskar Karlsson SciLifeLab Fellow
PubMed DOI Crossref
Integrative functional analysis uncovers metabolic differences between Candida species.
Begum N, Lee S, Portlock TJ, ..., Moyes DL, Shoaie S
Commun Biol 5 (1) 1013 [2022-09-26; online 2022-09-26]
Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Host-mycobiome metabolic interactions in health and disease.
Begum N, Harzandi A, Lee S, ..., Moyes DL, Shoaie S
Gut Microbes 14 (1) 2121576 [2022-09-25; online 2022-09-25]
Saeed Shoaie SciLifeLab Fellow
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Ribosomal protein with conserved function has entirely different structures in different organisms
Schierholz L, Brown CR, Helena-Bueno K, ..., Barandun J, Melnikov SV
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Jonas Barandun SciLifeLab Fellow
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EukProt: A database of genome-scale predicted proteins across the diversity of eukaryotes
Richter DJ, Berney C, Strassert JFH, ..., Burki F, de Vargas C
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Fabien Burki SciLifeLab Fellow
PubMed DOI Crossref
Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data.
Weiss MS, Wollenhaupt J, Correy GJ, ..., Thunissen M, Pearce NM
Protein Sci. 31 (9) e4391 [2022-09-00; online 2022-08-31]
DDLS Fellow Nicholas Pearce
PubMed DOI Crossref
Microbial and human transcriptome in vaginal fluid at midgestation: Association with spontaneous preterm delivery.
Wikström T, Abrahamsson S, Bengtsson-Palme J, ..., Valentin L, Hagberg H
Clin Transl Med 12 (9) e1023 [2022-09-00; online 2022-09-15]
DDLS Fellow Johan Bengtsson-Palme
PubMed DOI Crossref
Laboratory Misidentifications Resulting from Taxonomic Changes to Bacillus cereus Group Species, 2018-2022.
Carroll LM, Matle I, Kovac J, Cheng RA, Wiedmann M
Emerg Infect Dis 28 (9) 1877-1881 [2022-09-00; online 2022-08-24]
DDLS Fellow Laura Carroll
PubMed DOI Crossref
Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity.
Zhang X, Akcan E, Correia M, ..., Globisch D, Sjöblom T
Biochem. Pharmacol. 203 (-) 115184 [2022-09-00; online 2022-07-22]
Daniel Globisch SciLifeLab Fellow
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Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties.
Ragaller F, Andronico L, Sykora J, ..., Vattulainen I, Sezgin E
Open Biol 12 (9) 220175 [2022-09-00; online 2022-09-14]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors.
Joffré E, Xiao X, Correia MSP, ..., Zhu B, Sjöling Å
Microbiol Spectr 10 (4) e0175521 [2022-08-31; online 2022-07-25]
Daniel Globisch SciLifeLab Fellow
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TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.
Stolz P, Mantero AS, Tvardovskiy A, ..., Elsässer SJ, Bultmann S
Nucleic Acids Res. 50 (15) 8491-8511 [2022-08-26; online 2022-07-30]
SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
Evolutionary consequences of genomic deletions and insertions in the woolly mammoth genome.
van der Valk T, Dehasque M, Chacón-Duque JC, ..., Díez-Del-Molino D, Dalén L
iScience 25 (8) 104826 [2022-08-19; online 2022-08-01]
DDLS Fellow Tom van der Valk
PubMed DOI Crossref
The origin and evolution of open habitats in North America inferred by Bayesian deep learning models.
Andermann T, Strömberg CAE, Antonelli A, Silvestro D
Nat Commun 13 (1) 4833 [2022-08-17; online 2022-08-17]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Zeitotox: Toxicology and the Rhythms of Life.
Xiao L, Antczak P, Rüegg J, Behrendt L
Environ. Sci. Technol. 56 (16) 11100-11102 [2022-08-16; online 2022-07-27]
Lars Behrendt SciLifeLab Fellow
PubMed DOI Crossref
Microbial functional genes are driven by gradients in sediment stoichiometry, oxygen, and salinity across the Baltic benthic ecosystem.
Broman E, Izabel-Shen D, Rodríguez-Gijón A, ..., Garcia SL, Nascimento FJA
Microbiome 10 (1) 126 [2022-08-15; online 2022-08-15]
Sarahi Garcia SciLifeLab Fellow
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Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.
Hansen JY, Shafiei G, Vogel JW, ..., Dagher A, Misic B
Nat Commun 13 (1) 4682 [2022-08-10; online 2022-08-10]
Jacob W Vogel
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A Universal Language for Finding Mass Spectrometry Data Patterns
Jarmusch AK, Aron AT, Petras D, ..., Dorrestein PC, Wang M
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Daniel Globisch SciLifeLab Fellow
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Adult Exposure to Di-N-Butyl Phthalate (DBP) Induces Persistent Effects on Testicular Cell Markers and Testosterone Biosynthesis in Mice.
Källsten L, Almamoun R, Pierozan P, ..., Martin JW, Karlsson O
Int J Mol Sci 23 (15) - [2022-08-05; online 2022-08-05]
Oskar Karlsson SciLifeLab Fellow
PubMed DOI Crossref
What can cold-induced transcriptomes of Arctic Brassicaceae tell us about the evolution of cold tolerance?
Birkeland S, Slotte T, Krag Brysting A, ..., Brochmann C, Nowak MD
Mol. Ecol. 31 (16) 4271-4285 [2022-08-00; online 2022-07-15]
SciLifeLab Fellow Tanja Slotte
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The anti-inflammatory peptide Catestatin blocks chemotaxis.
Muntjewerff EM, Parv K, Mahata SK, ..., Christoffersson G, van den Bogaart G
J Leukoc Biol 112 (2) 273-278 [2022-08-00; online 2021-12-22]
Gustaf Christoffersson SciLifeLab Fellow
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Recent and local diversification of Central American understorey palms
Cano Á, Stauffer FW, Andermann T, ..., Perret M, Antonelli A
Global Ecol. Biogeogr. 31 (8) 1513-1525 [2022-08-00; online 2022-05-11]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Photophysiological response of Symbiodiniaceae single cells to temperature stress.
Xiao L, Johansson S, Rughöft S, ..., Tenje M, Behrendt L
ISME J 16 (8) 2060-2064 [2022-08-00; online 2022-04-26]
Fabien Burki Lars Behrendt SciLifeLab Fellow
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Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals.
Berdan EL, Blanckaert A, Butlin RK, ..., Slotte T, Wielstra B
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 377 (1856) 20210199 [2022-08-00; online 2022-06-13]
SciLifeLab Fellow Tanja Slotte
PubMed DOI Crossref
Strains Associated with Two 2020 Welder Anthrax Cases in the United States Belong to Separate Lineages within Bacillus cereus sensu lato.
Carroll LM, Marston CK, Kolton CB, ..., Weiner ZP, Kovac J
Pathogens 11 (8) - [2022-07-29; online 2022-07-29]
DDLS Fellow Laura Carroll
PubMed DOI Crossref
Issues and recommendations for the residual approach to quantifying cognitive resilience and reserve.
Elman JA, Vogel JW, Bocancea DI, ..., Kremen WS, Alzheimer’s Disease Neuroimaging Initiative
Alzheimers Res Ther 14 (1) 102 [2022-07-25; online 2022-07-25]
Jacob W Vogel
DOI Crossref
Robust and integrative Bayesian neural networks for likelihood-free parameter inference
Wrede F, Eriksson R, Jiang R, ..., Hellander A, Singh P
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Prashant Singh SciLifeLab Fellow
PubMed DOI Crossref
Genome-scale metabolic modelling of the human gut microbiome reveals changes in the glyoxylate and dicarboxylate metabolism in metabolic disorders.
Proffitt C, Bidkhori G, Lee S, ..., Moyes DL, Shoaie S
iScience 25 (7) 104513 [2022-07-15; online 2022-06-02]
Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Chi G, Liang Q, Sridhar A, ..., Covarrubias M, Dürr KL
Nat Commun 13 (1) 4087 [2022-07-15; online 2022-07-15]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation.
Zhu K, Wang Y, Sarlus H, ..., Högberg B, Harris RA
EMBO Rep. 23 (7) e54499 [2022-07-05; online 2022-05-20]
Claudia Kutter SciLifeLab Fellow
PubMed DOI Crossref
Biosynthetic potential of the global ocean microbiome.
Paoli L, Ruscheweyh HJ, Forneris CC, ..., Piel J, Sunagawa S
Nature 607 (7917) 111-118 [2022-07-00; online 2022-06-22]
DDLS Fellow Laura Carroll
PubMed DOI Crossref
Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines.
Jacobson KA, Gao ZG, Matricon P, Eddy MT, Carlsson J
Br J Pharmacol 179 (14) 3496-3511 [2022-07-00; online 2020-06-19]
Jens Carlsson SciLifeLab Fellow
PubMed DOI Crossref
The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle.
Krog MC, Hugerth LW, Fransson E, ..., Schuppe-Koistinen I, Nielsen HS
Hum. Reprod. 37 (7) 1525-1543 [2022-06-30; online 2022-05-14]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
Genomic Sequencing of Bacillus cereus Sensu Lato Strains Isolated from Meat and Poultry Products in South Africa Enables Inter- and Intranational Surveillance and Source Tracking.
Carroll LM, Pierneef R, Mathole A, Atanda A, Matle I
Microbiol Spectr 10 (3) e0070022 [2022-06-29; online 2022-04-27]
DDLS Fellow Laura Carroll
PubMed DOI Crossref
HSFs drive transcription of distinct genes and enhancers during oxidative stress and heat shock.
Himanen SV, Puustinen MC, Da Silva AJ, Vihervaara A, Sistonen L
Nucleic Acids Res. 50 (11) 6102-6115 [2022-06-24; online 2022-06-11]
Anniina Vihervaara SciLifeLab Fellow
PubMed DOI Crossref
The VirF21:VirF30 protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion.
Skovajsová E, Colonna B, Prosseda G, Sellin ME, Di Martino ML
FEMS Microbiol. Lett. 369 (1) - [2022-06-22; online 2022-05-07]
Mikael Sellin SciLifeLab Fellow
PubMed DOI Crossref
T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.
Céspedes PF, Jainarayanan A, Fernández-Messina L, ..., Sánchez-Madrid F, Dustin ML
Nat Commun 13 (1) 3460 [2022-06-16; online 2022-06-16]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Differential grey matter structure in women with premenstrual dysphoric disorder: evidence from brain morphometry and data-driven classification.
Dubol M, Stiernman L, Wikström J, ..., Bixo M, Comasco E
Transl Psychiatry 12 (1) 250 [2022-06-15; online 2022-06-15]
Erika Comasco SciLifeLab Fellow
PubMed DOI Crossref
GenErode: a bioinformatics pipeline to investigate genome erosion in endangered and extinct species.
Kutschera VE, Kierczak M, van der Valk T, ..., Dalén L, Díez-Del-Molino D
BMC Bioinformatics 23 (1) 228 [2022-06-13; online 2022-06-13]
DDLS Fellow Tom van der Valk
Incidensen av levercancer ökar över hela världen
Kutter C
Onkologi i Sverige - (-) - [2022-06-10; online 2022-06-10]
Claudia Kutter SciLifeLab Fellow
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FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development.
Luu TT, Søndergaard JN, Peña-Pérez L, ..., Månsson R, Kadri N
Front Immunol 13 (-) 854312 [2022-06-09; online 2022-06-09]
Claudia Kutter SciLifeLab Fellow
PubMed DOI Crossref
Erratum: Long-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes.
Carravilla P, Dasgupta A, Zhurgenbayeva G, ..., Sezgin E, Eggeling C
Biophys Rep (N Y) 2 (2) None [2022-06-08; online 2022-06-08]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism.
Frampton DJA, Choudhury K, Nikesjö J, Delemotte L, Liin SI
Elife 11 (-) - [2022-06-01; online 2022-06-01]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
The relative role of plasticity and demographic history in Capsella bursa-pastoris: a common garden experiment in Asia and Europe.
Cornille A, Tiret M, Salcedo A, ..., Wright SI, Lascoux M
AoB Plants 14 (3) plac011 [2022-06-00; online 2022-04-02]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
The limits of human microRNA annotation have been met.
Fromm B, Zhong X, Tarbier M, Friedländer MR, Hackenberg M
RNA 28 (6) 781-785 [2022-06-00; online 2022-03-02]
Marc Friedländer SciLifeLab Fellow
PubMed DOI Crossref
TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.
Tsubakihara Y, Ohata Y, Okita Y, ..., Heldin CH, Moustakas A
Mol Oncol 16 (12) 2330-2354 [2022-06-00; online 2022-04-10]
Mikael Sellin SciLifeLab Fellow
PubMed DOI Crossref
Rapid in situ identification of biological specimens via DNA amplicon sequencing using miniaturized laboratory equipment.
Pomerantz A, Sahlin K, Vasiljevic N, ..., Ogden R, Prost S
Nat Protoc 17 (6) 1415-1443 [2022-06-00; online 2022-04-11]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Potato genomes pave the way to crop improvement.
Gutiérrez-Valencia J, Slotte T
Nature 606 (7914) 472-473 [2022-06-00; online 2022-06-09]
SciLifeLab Fellow Tanja Slotte
PubMed DOI Crossref
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation.
Kumar B, Navarro C, Winblad N, ..., Lanner F, Elsässer SJ
Nat. Cell Biol. 24 (6) 845-857 [2022-06-00; online 2022-05-30]
SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
OPUSeq simplifies detection of low-frequency DNA variants and uncovers fragmentase-associated artifacts.
Alekseenko A, Wang J, Barrett D, Pelechano V
NAR Genomics and Bioinformatics 4 (2) lqac048 [2022-06-00; online 2022-06-27]
SciLifeLab Fellow Vicent Pelechano
PubMed DOI Crossref
Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Itoh Y, Khawaja A, Laptev I, ..., Rorbach J, Amunts A
Nature 606 (7914) 603-608 [2022-06-00; online 2022-06-08]
Alexey Amunts SciLifeLab Fellow
PubMed DOI Crossref
Inhibition of Respiratory Syncytial Virus Infection by Small Non-Coding RNA Fragments.
Pålsson SA, Sekar V, Kutter C, Friedländer MR, Spetz AL
Int J Mol Sci 23 (11) - [2022-05-26; online 2022-05-26]
Claudia Kutter SciLifeLab Fellow
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Simultaneous visualization of flow fields and oxygen concentrations to unravel transport and metabolic processes in biological systems.
Ahmerkamp S, Jalaluddin FM, Cui Y, ..., Koren K, Behrendt L
Cell Rep Methods 2 (5) 100216 [2022-05-23; online 2022-05-23]
Lars Behrendt SciLifeLab Fellow
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Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms
Ansari SR, Hempel NJ, Asad S, ..., Löbmann K, Teleki A
ACS Appl Mater Interfaces 14 (19) 21978-21988 [2022-05-18; online 2022-04-22]
Alexandra Teleki SciLifeLab Fellow
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The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis.
Gudnadottir U, Debelius JW, Du J, ..., Fransson E, Brusselaers N
Sci Rep 12 (1) 7926 [2022-05-13; online 2022-05-13]
DDLS Fellow Luisa Hugerth
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Impact of Genome Reduction in Microsporidia.
Jespersen N, Monrroy L, Barandun J
Exp Suppl 114 (-) 1-42 [2022-05-12; online 2022-05-12]
Jonas Barandun SciLifeLab Fellow
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Patatin-like phospholipase CapV in Escherichia coli - morphological and physiological effects of one amino acid substitution.
Li F, Cao L, Bähre H, ..., Rohde M, Römling U
NPJ Biofilms Microbiomes 8 (1) 39 [2022-05-11; online 2022-05-11]
Kristina Jonas SciLifeLab Fellow
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Lipid-Protein Interactions in Plasma Membrane Organization and Function.
Sych T, Levental KR, Sezgin E
Annu Rev Biophys 51 (-) 135-156 [2022-05-09; online 2022-01-04]
Erdinc Sezgin SciLifeLab Fellow
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Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study.
Kallak TK, Fransson E, Bränn E, ..., Lyle R, Skalkidou A
Transl Psychiatry 12 (1) 186 [2022-05-05; online 2022-05-05]
Erika Comasco SciLifeLab Fellow
PubMed DOI Crossref
The right bug in the right place: opportunities for bacterial vaginosis treatment.
Wu S, Hugerth LW, Schuppe-Koistinen I, Du J
NPJ Biofilms Microbiomes 8 (1) 34 [2022-05-02; online 2022-05-02]
DDLS Fellow Luisa Hugerth
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Subtypes of Alzheimer's disease: questions, controversy, and meaning.
Vogel JW, Hansson O
Trends Neurosci 45 (5) 342-345 [2022-05-00; online 2022-02-25]
Jacob W Vogel
DOI Crossref
Scalable federated machine learning with FEDn
Ekmefjord M, Ait-Mlouk A, Alawadi S, ..., Toor S, Hellander A
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Prashant Singh SciLifeLab Fellow
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Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes.
Eriksson O, Velikyan I, Haack T, ..., Tillner J, Wagner M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 63 (5) 794-800 [2022-05-00; online 2021-09-09]
Olof Eriksson SciLifeLab Fellow
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Direct Observation of Na,K‐ATPase Oligomers in The Plasma Membrane of Living Cells by FRET‐FCS
Nordahl L, Wennmalm S, Jönsson J, ..., Akkuratov EE, Brismar H
The FASEB Journal 36 (S1) - [2022-05-00; online 2022-05-13]
SciLifeLab Fellow Simon Elsässer
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A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface.
Ek V, Fattinger SA, Florbrant A, ..., Eriksson J, Sellin ME
Mol. Microbiol. 117 (5) 1156-1172 [2022-05-00; online 2022-04-12]
Mikael Sellin SciLifeLab Fellow
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Understanding immune signaling using advanced imaging techniques.
Brameshuber M, Klotzsch E, Ponjavic A, Sezgin E
Biochem. Soc. Trans. 50 (2) 853-866 [2022-04-29; online 2022-03-29]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Global Estimation and Mapping of the Conservation Status of Tree Species Using Artificial Intelligence.
Silva SV, Andermann T, Zizka A, Kozlowski G, Silvestro D
Front Plant Sci 13 (-) 839792 [2022-04-29; online 2022-04-29]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress.
Larsen BD, Benada J, Yung PYK, ..., Bartek J, Sørensen CS
Science (New York, N.Y.) 376 (6592) 476-483 [2022-04-29; online 2022-04-28]
SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
Multiple Cortical to Striatal Accumulation Trajectories of β-Amyloid: Do All Roads Lead to Rome?
Vogel JW, Tosun D
Neurology 98 (17) 695-696 [2022-04-26; online 2022-03-25]
Jacob W Vogel
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Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies.
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Erika Comasco SciLifeLab Fellow
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Ferreira PL, Batista R, Andermann T, ..., Bacon CD, Antonelli A
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Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.
Laurén I, Havervall S, Ng H, ..., Thålin C, Mangsbo S
Immun Inflamm Dis 10 (4) e595 [2022-04-00; online 2022-03-30]
Gustaf Christoffersson SciLifeLab Fellow
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IgE cross-linking induces activation of human and mouse mast cell progenitors.
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Mikael Sellin SciLifeLab Fellow
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Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging.
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Nature 604 (7906) 525-533 [2022-04-00; online 2022-04-06]
Jacob W Vogel
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Associations between Listeria monocytogenes genomic characteristics and adhesion to polystyrene at 8 °C.
Mahoney DBJ, Falardeau J, Hingston P, ..., Jang SS, Wang S
Food Microbiol 102 (-) 103915 [2022-04-00; online 2021-09-23]
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Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
Mateus Brandão LE, Espes D, Westholm JO, ..., Benedict C, Cedernaes J
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Daniel Espes SciLifeLab Fellow
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The microbiome in reproductive health: protocol for a systems biology approach using a prospective, observational study design.
Krog MC, Madsen ME, Bliddal S, ..., Schuppe-Koistinen I, Nielsen HS
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DDLS Fellow Luisa Hugerth
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A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma.
Yuan M, Shong K, Li X, ..., Zhang C, Mardinoglu A
Cancers (Basel) 14 (6) - [2022-03-19; online 2022-03-19]
Saeed Shoaie SciLifeLab Fellow
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Quantifying RNA synthesis at rate-limiting steps of transcription using nascent RNA-sequencing data.
Rabenius A, Chandrakumaran S, Sistonen L, Vihervaara A
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SciLifeLab Fellow Simon Elsässer
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Nota K, Klaminder J, Milesi P, ..., Suyama Y, Parducci L
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Pascal Milesi SciLifeLab Fellow
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A broad, exposome-type evaluation of xenobiotic phase II biotransformation in human biofluids by LC-MS/MS
Fareed Y, Braun D, Flasch M, Globisch D, Warth B
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Daniel Globisch SciLifeLab Fellow
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Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
Garcia Morato J, Hans F, von Zweydorf F, ..., Neumann M, Kahle PJ
Nat Commun 13 (1) 1223 [2022-03-09; online 2022-03-09]
SciLifeLab Fellow Simon Elsässer
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Wood TM, Zeronian MR, Buijs N, ..., Janssen BJC, Martin NI
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The SWI/SNF subunit BRG1 affects alternative splicing by changing RNA binding factor interactions with nascent RNA.
Gañez-Zapater A, Mackowiak SD, Guo Y, ..., Visa N, Östlund Farrants AK
Mol. Genet. Genomics 297 (2) 463-484 [2022-03-00; online 2022-02-20]
Marc Friedländer SciLifeLab Fellow
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On the origin of TSAR: morphology, diversity and phylogeny of Telonemia.
Tikhonenkov DV, Jamy M, Borodina AS, ..., Burki F, Karpov SA
Open Biol 12 (3) 210325 [2022-03-00; online 2022-03-16]
Fabien Burki SciLifeLab Fellow
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Oskar Karlsson SciLifeLab Fellow
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ADAR1- and ADAR2-mediated regulation of maturation and targeting of miR-376b to modulate GABA neurotransmitter catabolism.
Widmark A, Sagredo EA, Karlström V, ..., Daniel C, Öhman M
J Biol Chem 298 (3) 101682 [2022-03-00; online 2022-02-03]
Marc Friedländer SciLifeLab Fellow
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Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
Begnini F, Geschwindner S, Johansson P, ..., Schiesser S, Kihlberg J
J Med Chem 65 (4) 3473-3517 [2022-02-24; online 2022-02-02]
Jens Carlsson SciLifeLab Fellow
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White matter microstructure and volume correlates of premenstrual dysphoric disorder.
Gu X, Dubol M, Stiernman L, ..., Sundström-Poromaa I, Comasco E
J Psychiatry Neurosci 47 (1) E67-E76 [2022-02-23; online 2022-02-23]
Erika Comasco SciLifeLab Fellow
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Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
Luttens A, Gullberg H, Abdurakhmanov E, ..., Danielson UH, Carlsson J
Journal of the American Chemical Society 144 (7) 2905-2920 [2022-02-23; online 2022-02-10]
Jens Carlsson SciLifeLab Fellow
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Identification of electroporation sites in the complex lipid organization of the plasma membrane.
Rems L, Tang X, Zhao F, ..., Testa I, Delemotte L
Elife 11 (-) - [2022-02-23; online 2022-02-23]
Lucie Delemotte SciLifeLab Fellow
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Genome-wide mapping of G-quadruplex structures with CUT&Tag.
Lyu J, Shao R, Kwong Yung PY, Elsässer SJ
Nucleic Acids Res. 50 (3) e13 [2022-02-22; online 2021-11-19]
SciLifeLab Fellow Simon Elsässer
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Tumorigenic activity of alternative per- and polyfluoroalkyl substances (PFAS): Mechanistic in vitro studies.
Pierozan P, Cattani D, Karlsson O
Sci. Total Environ. 808 (-) 151945 [2022-02-20; online 2021-11-27]
Oskar Karlsson SciLifeLab Fellow
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Prevalence and correlates of current suicidal ideation in women with premenstrual dysphoric disorder.
Wikman A, Sacher J, Bixo M, ..., Comasco E, Sundström Poromaa I
BMC Womens Health 22 (1) 35 [2022-02-11; online 2022-02-11]
Erika Comasco SciLifeLab Fellow
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Neophytou C, Heer K, Milesi P, ..., Rellstab C, Gugerli F
Tree Genet Genomes 18 (2) 12 [2022-02-09; online 2022-02-09]
Pascal Milesi SciLifeLab Fellow
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Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae.
Nadeem A, Berg A, Pace H, ..., Uhlin BE, Wai SN
Elife 11 (-) - [2022-02-08; online 2022-02-08]
Jonas Barandun SciLifeLab Fellow
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Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells.
Archer A, Kutter C, Williams C
Methods in molecular biology (Clifton, N.J.) 2418 (-) 313-343 [2022-02-05; online 2022-02-05]
Claudia Kutter SciLifeLab Fellow
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ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export.
Malla S, Prasad Bhattarai D, Groza P, ..., Kutter C, Aguilo F
EMBO Rep. 23 (3) e53191 [2022-02-03; online 2022-01-17]
Claudia Kutter SciLifeLab Fellow
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Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis.
Baur P, Kühl M, Comba P, Behrendt L
Mar Drugs 20 (2) - [2022-02-02; online 2022-02-02]
Lars Behrendt SciLifeLab Fellow
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High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium.
van Rijn JM, Eriksson J, Grüttner J, ..., Svärd SG, Sellin ME
MBio 13 (1) e0002222 [2022-02-01; online 2022-02-01]
Mikael Sellin SciLifeLab Fellow
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ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal
Jalalvand E, Alvelid J, Coceano G, ..., Grillner S, Testa I
Elife 11 (-) - [2022-02-01; online 2022-02-01]
Ilaria Testa SciLifeLab Fellow
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Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.
Leuzy A, Smith R, Cullen NC, ..., Stomrud E, Hansson O
JAMA Neurol 79 (2) 149-158 [2022-02-01; online 2021-12-21]
Jacob W Vogel
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Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging.
Michno W, Wehrli PM, Koutarapu S, ..., Hopf C, Hanrieder J
J. Neurochem. 160 (4) 482-498 [2022-02-00; online 2021-12-26]
SciLifeLab Fellow Wojciech Michno
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Rifaximin-α reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial.
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J Hepatol 76 (2) 332-342 [2022-02-00; online 2021-09-24]
Saeed Shoaie SciLifeLab Fellow
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<i>IUCNN</i> – Deep learning approaches to approximate species' extinction risk
Zizka A, Andermann T, Silvestro D
Diversity and Distributions 28 (2) 227-241 [2022-02-00; online 2021-12-16]
DDLS Fellow Tobias Andermann
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Meta-analysis reveals the global picture of antibiotic resistance gene prevalence across environments
Abramova A, Berendonk TU, Bengtsson-Palme J
bioRxiv preprint - (-) - [2022-01-30; online 2022-01-30]
DDLS Fellow Johan Bengtsson-Palme
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Sequence specificity in DNA binding is mainly governed by association.
Marklund E, Mao G, Yuan J, ..., Deindl S, Elf J
Science (New York, N.Y.) 375 (6579) 442-445 [2022-01-28; online 2022-01-27]
SciLifeLab Fellow Sebastian Deindl
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Role of Cellular Metabolism during Candida-Host Interactions.
Pellon A, Begum N, Sadeghi Nasab SD, ..., Shoaie S, Moyes DL
Pathogens 11 (2) - [2022-01-28; online 2022-01-28]
Saeed Shoaie SciLifeLab Fellow
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Irisin-A Pancreatic Islet Hormone.
Norman D, Drott CJ, Carlsson PO, Espes D
Biomedicines 10 (2) - [2022-01-25; online 2022-01-25]
Daniel Espes SciLifeLab Fellow
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BioRssay: an R package for analyses of bioassays and probit graphs.
Karunarathne P, Pocquet N, Labbé P, Milesi P
Parasit Vectors 15 (1) 35 [2022-01-24; online 2022-01-24]
Pascal Milesi SciLifeLab Fellow
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CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism.
Søndergaard JN, Sommerauer C, Atanasoai I, ..., Barragan I, Kutter C
Gut 71 (10) 2081-2092 [2022-01-12; online 2022-01-12]
Claudia Kutter SciLifeLab Fellow
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A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.
Hanke L, Das H, Sheward DJ, ..., Murrell B, McInerney GM
Nat Commun 13 (1) 155 [2022-01-10; online 2022-01-10]
Erdinc Sezgin SciLifeLab Fellow
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MirGeneDB 2.1: toward a complete sampling of all major animal phyla.
Fromm B, Høye E, Domanska D, ..., Friedländer MR, Peterson KJ
Nucleic Acids Res. 50 (D1) D204-D210 [2022-01-07; online 2021-12-02]
Marc Friedländer SciLifeLab Fellow
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TRP channels: branching out into the fungal kingdom.
Hellmich UA, Delemotte L
Structure 30 (1) 2-4 [2022-01-06; online 2022-01-08]
Lucie Delemotte SciLifeLab Fellow
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A Genomic Perspective Across Earth's Microbiomes Reveals That Genome Size in Archaea and Bacteria Is Linked to Ecosystem Type and Trophic Strategy.
Rodríguez-Gijón A, Nuy JK, Mehrshad M, ..., Woyke T, Garcia SL
Front Microbiol 12 (-) 761869 [2022-01-05; online 2022-01-05]
Sarahi Garcia SciLifeLab Fellow
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Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
Bossart M, Wagner M, Elvert R, ..., Nitsche A, Konkar A
Cell Metab. 34 (1) 59-74.e10 [2022-01-04; online 2021-12-20]
Olof Eriksson SciLifeLab Fellow
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An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine.
Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L
Biophys. J. 121 (1) 11-22 [2022-01-04; online 2021-12-08]
Lucie Delemotte SciLifeLab Fellow
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Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins.
Schlesinger D, Elsässer SJ
FEBS J. 289 (1) 53-74 [2022-01-00; online 2021-02-24]
SciLifeLab Fellow Simon Elsässer
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Putative regulation of macrophage-mediated inflammation by catestatin.
Muntjewerff EM, Christoffersson G, Mahata SK, van den Bogaart G
Trends Immunol. 43 (1) 41-50 [2022-01-00; online 2021-11-27]
Gustaf Christoffersson SciLifeLab Fellow
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Identification of dynamic mass-action biochemical reaction networks using sparse Bayesian methods.
Jiang R, Singh P, Wrede F, Hellander A, Petzold L
PLoS Comput Biol 18 (1) e1009830 [2022-01-00; online 2022-01-31]
Prashant Singh SciLifeLab Fellow
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Distinct transcription kinetics of pluripotent cell states.
Shao R, Kumar B, Lidschreiber K, ..., Cramer P, Elsässer SJ
Mol Syst Biol 18 (1) e10407 [2022-01-00; online 2022-01-13]
SciLifeLab Fellow Simon Elsässer
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Cell type-specific analysis by single-cell profiling identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons.
Gao W, Gallardo-Dodd CJ, Kutter C
Genome Res 32 (1) 97-110 [2022-01-00; online 2021-12-02]
Claudia Kutter SciLifeLab Fellow
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Enhanced Sampling Methods for Molecular Dynamics Simulations [Article v1.0]
Hénin J, Lelièvre T, Shirts MR, Valsson O, Delemotte L
LiveCoMS 4 (1) - [2022-00-00; online 2022-00-00]
Lucie Delemotte SciLifeLab Fellow
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Potential of [11C]UCB-J as a PET tracer for islets of Langerhans.
Puuvuori E, Rokka J, Carlsson PO, ..., Eriksson J, Eriksson O
Sci Rep 11 (1) 24466 [2021-12-28; online 2021-12-28]
Olof Eriksson SciLifeLab Fellow
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Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle.
Vallianatou T, Bèchet NB, Correia MSP, Lundgaard I, Globisch D
Metabolites 12 (1) - [2021-12-27; online 2021-12-27]
Daniel Globisch SciLifeLab Fellow
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Accurate spliced alignment of long RNA sequencing reads
Sahlin K, Mäkinen V
Bioinformatics 37 (24) 4643-4651 [2021-12-11; online 2021-07-24]
Kristoffer Sahlin SciLifeLab Fellow
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Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme
Kaynar A, Altay O, Li X, ..., Shoaie S, Mardinoglu A
Int J Mol Sci 22 (24) 13213 [2021-12-08; online 2021-12-08]
Saeed Shoaie SciLifeLab Fellow
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Long-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes.
Carravilla P, Dasgupta A, Zhurgenbayeva G, ..., Sezgin E, Eggeling C
Biophys Rep (N Y) 1 (2) None [2021-12-08; online 2021-12-08]
Erdinc Sezgin SciLifeLab Fellow
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Genomic Signatures of Sexual Selection on Pollen-Expressed Genes in Arabis alpina.
Gutiérrez-Valencia J, Fracassetti M, Horvath R, ..., Kolář F, Slotte T
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SciLifeLab Fellow Tanja Slotte
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What Is the Role of the Environment in the Emergence of Novel Antibiotic Resistance Genes? A Modeling Approach.
Bengtsson-Palme J, Jonsson V, Heß S
Environ. Sci. Technol. 55 (23) 15734-15743 [2021-12-07; online 2021-11-18]
DDLS Fellow Johan Bengtsson-Palme
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Proactive autoscaling for edge computing systems with kubernetes
Ju L, Singh P, Toor S
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Prashant Singh SciLifeLab Fellow
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The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies.
Cheung P, Eriksson O
Biomedicines 9 (12) - [2021-12-03; online 2021-12-03]
Olof Eriksson SciLifeLab Fellow
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Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire.
Fattinger SA, Sellin ME, Hardt WD
Curr Opin Microbiol 64 (-) 9-18 [2021-12-00; online 2021-09-06]
Mikael Sellin SciLifeLab Fellow
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A bioinformatic platform to integrate target capture and whole genome sequences of various read depths for phylogenomics.
G Ribeiro P, Torres Jiménez MF, Andermann T, ..., Bacon CD, Matos-Maraví P
Mol. Ecol. 30 (23) 6021-6035 [2021-12-00; online 2021-10-31]
DDLS Fellow Tobias Andermann
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Safety in multi-assembly via paths appearing in all path covers of a DAG.
Caceres M, Mumey B, Husic E, ..., Sahlin K, Tomescu AII
IEEE/ACM Trans Comput Biol Bioinform PP (-) - [2021-11-30; online 2021-11-30]
Kristoffer Sahlin SciLifeLab Fellow
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Genomic and niche divergence in an Amazonian palm species complex
Bacon CD, Roncal J, Andermann T, ..., Tunarosa N, Antonelli A
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DDLS Fellow Tobias Andermann
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Fragment-based design of selective GPCR ligands guided by free energy simulations.
Matricon P, Vo DD, Gao ZG, ..., Jacobson KA, Carlsson J
Chem. Commun. (Camb.) 57 (92) 12305-12308 [2021-11-19; online 2021-11-19]
Jens Carlsson SciLifeLab Fellow
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Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae.
Schön ME, Zlatogursky VV, Singh RP, ..., Wideman JG, Burki F
Nat Commun 12 (1) 6651 [2021-11-17; online 2021-11-17]
Fabien Burki SciLifeLab Fellow
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Using High-Sensitivity Lipidomics To Assess Microscale Heterogeneity in Oceanic Sinking Particles and Single Phytoplankton Cells.
Hunter JE, Fredricks HF, Behrendt L, ..., Stocker R, Van Mooy BAS
Environ. Sci. Technol. 55 (22) 15456-15465 [2021-11-16; online 2021-11-01]
Lars Behrendt SciLifeLab Fellow
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MapToCleave: High-throughput profiling of microRNA biogenesis in living cells.
Kang W, Fromm B, Houben AJ, ..., Biryukova I, Friedländer MR
Cell Reports 37 (7) 110015 [2021-11-16; online 2021-11-18]
Marc Friedländer SciLifeLab Fellow
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Engineered Human Induced Pluripotent Cells Enable Genetic Code Expansion in Brain Organoids.
van Husen LS, Katsori AM, Meineke B, ..., Schedin-Weiss S, Elsässer SJ
Chembiochem 22 (22) 3208-3213 [2021-11-16; online 2021-09-13]
SciLifeLab Fellow Simon Elsässer
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Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor.
Chen Y, Fleetwood O, Pérez-Conesa S, Delemotte L
J Chem Inf Model - (-) - [2021-11-15; online 2021-11-15]
Lucie Delemotte SciLifeLab Fellow
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A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling.
Meineke B, Heimgärtner J, Craig AJ, ..., Moodie LWK, Elsässer SJ
Front Chem 9 (-) 768535 [2021-11-11; online 2021-11-11]
SciLifeLab Fellow Simon Elsässer
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Large-scale identification of RBP-RNA interactions by RAPseq refines essentials of post-transcriptional gene regulation
Atanasoai I, Papavasileiou S, Preiß N, Kutter C
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Claudia Kutter SciLifeLab Fellow
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Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF.
Hausmann A, Felmy B, Kunz L, ..., Sellin ME, Hardt WD
J. Exp. Med. 218 (11) - [2021-11-01; online 2021-09-16]
Mikael Sellin SciLifeLab Fellow
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Ploscariu N, Burnley T, Gros P, Pearce NM
Acta Crystallogr D Struct Biol 77 (Pt 11) 1357-1364 [2021-11-01; online 2021-10-20]
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Sahlin K
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Scharnweber K, Peura S, Attermeyer K, ..., Tranvik LJ, Székely AJ
Limnol Oceanogr Methods - (-) - [2021-10-28; online 2021-10-28]
Sarahi Garcia SciLifeLab Fellow
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Bayraktar A, Lam S, Altay O, ..., Shoaie S, Mardinoglu A
Int J Mol Sci 22 (21) 11556 [2021-10-26; online 2021-10-26]
Saeed Shoaie SciLifeLab Fellow
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Omnus DJ, Fink MJ, Szwedo K, Jonas K
Elife 10 (-) - [2021-10-25; online 2021-10-25]
Kristina Jonas SciLifeLab Fellow
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Carroll LM, Buehler AJ, Gaballa A, ..., Cheng RA, Wiedmann M
Front Microbiol 12 (-) 763669 [2021-10-18; online 2021-10-18]
DDLS Fellow Laura Carroll
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Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites.
Lin W, Conway LP, Vujasinovic M, Löhr JM, Globisch D
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Daniel Globisch SciLifeLab Fellow
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Bergström P, Trybala E, Eriksson CE, ..., Zetterberg H, Bergström T
Viruses 13 (10) - [2021-10-14; online 2021-10-14]
SciLifeLab Fellow Wojciech Michno
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Cohn AR, Orsi RH, Carroll LM, ..., Wiedmann M, Cheng RA
Front Microbiol 12 (-) 730411 [2021-10-13; online 2021-10-13]
DDLS Fellow Laura Carroll
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Burki F, Sandin MM, Jamy M
Curr. Biol. 31 (19) R1267-R1280 [2021-10-11; online 2021-10-13]
Fabien Burki SciLifeLab Fellow
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Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines.
Lin W, Yang Z, Kaur A, ..., Löhr JM, Globisch D
RSC Chem Biol 2 (5) 1479-1483 [2021-10-07; online 2021-08-12]
Daniel Globisch SciLifeLab Fellow
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Zhu K, Wang Y, Sarlus H, ..., Högberg B, Harris RA
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Claudia Kutter SciLifeLab Fellow
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Genomic Characterization of Endemic and Ecdemic Non-typhoidal Salmonella enterica Lineages Circulating Among Animals and Animal Products in South Africa.
Carroll LM, Pierneef R, Mathole M, Matle I
Front Microbiol 12 (-) 748611 [2021-10-04; online 2021-10-04]
DDLS Fellow Laura Carroll
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Differential susceptibility of rat primary neurons and neural stem cells to PFOS and PFOA toxicity.
Pierozan P, Karlsson O
Toxicol. Lett. 349 (-) 61-68 [2021-10-01; online 2021-06-11]
Oskar Karlsson SciLifeLab Fellow
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Structure-Based Virtual Screening for Ligands of G Protein-Coupled Receptors: What Can Molecular Docking Do for You?
Ballante F, Kooistra AJ, Kampen S, de Graaf C, Carlsson J
Pharmacol Rev 73 (4) 527-565 [2021-10-00; online 2021-12-16]
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Sinking enhances the degradation of organic particles by marine bacteria
Alcolombri U, Peaudecerf FJ, Fernandez VI, ..., Lee KS, Stocker R
Nat. Geosci. 14 (10) 775-780 [2021-10-00; online 2021-09-23]
Lars Behrendt SciLifeLab Fellow
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Refining the amyloid β peptide and oligomer fingerprint ambiguities in Alzheimer's disease: Mass spectrometric molecular characterization in brain, cerebrospinal fluid, blood, and plasma.
Michno W, Blennow K, Zetterberg H, Brinkmalm G
J. Neurochem. 159 (2) 234-257 [2021-10-00; online 2021-07-27]
SciLifeLab Fellow Wojciech Michno
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 9: Polymyxins: colistin.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06861 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 8: Pleuromutilins: tiamulin and valnemulin.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06860 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 7: Amphenicols: florfenicol and thiamphenicol.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06859 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06858 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 5: Lincosamides: lincomycin.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06856 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 4: β-Lactams: amoxicillin and penicillin V.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06855 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 3: Amprolium.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06854 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 2: Aminoglycosides/aminocyclitols: apramycin, paromomycin, neomycin and spectinomycin.
EFSA Panel on Biological Hazards (BIOHAZ) , Allende A, Koutsoumanis K, ..., Stella P, Peixe L
EFSA J 19 (10) e06853 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 1: Methodology, general data gaps and uncertainties.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06852 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 13: Diaminopyrimidines: trimethoprim.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06865 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06864 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 11: Sulfonamides.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06863 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 10: Quinolones: flumequine and oxolinic acid.
EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
EFSA J 19 (10) e06862 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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Corrigendum: Ancient microRNA profiles of 14,300-yr-old canid samples confirm taxonomic origin and provide glimpses into tissue-specific gene regulation from the Pleistocene.
Fromm B, Tarbier M, Smith O, ..., Gilbert MTP, Friedländer MR
RNA 27 (10) 1291 [2021-10-00; online 2021-09-18]
Marc Friedländer SciLifeLab Fellow
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Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
Zeybel M, Altay O, Arif M, ..., Borén J, Mardinoglu A
Mol Syst Biol 17 (10) e10459 [2021-10-00; online 2021-10-26]
Saeed Shoaie SciLifeLab Fellow
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Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review.
Bürger Z, Bucher AM, Comasco E, ..., Kogler L, Derntl B
Front Neuroendocrinol 63 (-) 100943 [2021-10-00; online 2021-08-20]
Erika Comasco SciLifeLab Fellow
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A practical guide to large-scale docking.
Bender BJ, Gahbauer S, Luttens A, ..., Irwin JJ, Shoichet BK
Nat Protoc 16 (10) 4799-4832 [2021-10-00; online 2021-09-24]
Jens Carlsson SciLifeLab Fellow
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An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.
Mangsbo SM, Havervall S, Laurén I, ..., Klingström J, Thålin C
PLoS ONE 16 (9) e0258041 [2021-09-30; online 2021-09-30]
Gustaf Christoffersson SciLifeLab Fellow
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Improved Radiolytic Stability of a 68Ga-labelled Collagelin Analogue for the Imaging of Fibrosis.
Velikyan I, Rosenström U, Rosestedt M, Eriksson O, Antoni G
Pharmaceuticals (Basel, Switzerland) 14 (10) - [2021-09-28; online 2021-09-28]
Olof Eriksson SciLifeLab Fellow
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Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69.
Persson J, Puuvuori E, Zhang B, ..., Eriksson O, Löfblom J
Sci Rep 11 (1) 19151 [2021-09-27; online 2021-09-27]
Olof Eriksson SciLifeLab Fellow
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Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
McCoull W, Boyd S, Brown MR, ..., Zhu Q, Smith PD
J Med Chem 64 (18) 13524-13539 [2021-09-23; online 2021-09-03]
SciLifeLab Fellow Yumeng Mao
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A method for intuitively extracting macromolecular dynamics from structural disorder
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Nat Commun 12 (1) - [2021-09-17; online 2021-09-17]
DDLS Fellow Nicholas Pearce
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A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability.
Felletti M, Romilly C, Wagner EGH, Jonas K
Elife 10 (-) - [2021-09-15; online 2021-09-15]
Kristina Jonas SciLifeLab Fellow
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Selection on accessible chromatin regions in Capsella grandiflora.
Horvath R, Josephs EB, Pesquet E, ..., Scofield D, Slotte T
Mol. Biol. Evol. - (-) - [2021-09-08; online 2021-09-08]
SciLifeLab Fellow Tanja Slotte
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
von Beek C, Alriksson L, Palle J, ..., Sellin ME, Pejler G
PLoS ONE 16 (9) e0256708 [2021-09-07; online 2021-09-07]
Mikael Sellin SciLifeLab Fellow
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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
Bacic L, Gaullier G, Sabantsev A, ..., Boulton SJ, Deindl S
Elife 10 (-) - [2021-09-06; online 2021-09-06]
SciLifeLab Fellow Sebastian Deindl
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The long-time orphan protist Meringosphaera mediterranea Lohmann, 1902 [1903] is a centrohelid heliozoan.
Zlatogursky VV, Shɨshkin Y, Drachko D, Burki F
J. Eukaryot. Microbiol. 68 (5) e12860 [2021-09-00; online 2021-07-12]
Fabien Burki SciLifeLab Fellow
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RecA finds homologous DNA by reduced dimensionality search.
Wiktor J, Gynnå AH, Leroy P, ..., Testa I, Elf J
Nature 597 (7876) 426-429 [2021-09-00; online 2021-09-01]
Ilaria Testa SciLifeLab Fellow
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Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia.
Draper-Joyce CJ, Bhola R, Wang J, ..., Imlach WL, Christopoulos A
Nature 597 (7877) 571-576 [2021-09-00; online 2021-09-08]
Jens Carlsson SciLifeLab Fellow
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Killing two enemies with one stone? Genomics of resistance to two sympatric pathogens in Norway spruce.
Capador-Barreto HD, Bernhardsson C, Milesi P, ..., Stenlid J, Elfstrand M
Mol. Ecol. 30 (18) 4433-4447 [2021-09-00; online 2021-08-05]
Pascal Milesi SciLifeLab Fellow
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Synergies of Systems Biology and Synthetic Biology in Human Microbiome Studies.
Ezzamouri B, Shoaie S, Ledesma-Amaro R
Front Microbiol 12 (-) 681982 [2021-08-31; online 2021-08-31]
Saeed Shoaie SciLifeLab Fellow
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Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A.
Allen GE, Panasenko OO, Villanyi Z, ..., Ignatova Z, Collart MA
Cell Reports 36 (9) 109633 [2021-08-31; online 2021-09-02]
SciLifeLab Fellow Vicent Pelechano
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Convolutional Neural Networks as Summary Statistics for Approximate Bayesian Computation.
Akesson M, Singh P, Wrede F, Hellander A
IEEE/ACM Trans Comput Biol Bioinform PP (-) - [2021-08-30; online 2021-08-30]
Prashant Singh SciLifeLab Fellow
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Structure and Sequence-based Computational Approaches to Allosteric Signal Transduction: Application to Electromechanical Coupling in Voltage-gated Ion Channels.
Elbahnsi A, Delemotte L
J. Mol. Biol. 433 (17) 167095 [2021-08-20; online 2021-06-06]
Lucie Delemotte SciLifeLab Fellow
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Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5.
Galleano I, Harms H, Choudhury K, ..., Delemotte L, Pless SA
Proc. Natl. Acad. Sci. U.S.A. 118 (33) - [2021-08-17; online 2021-08-11]
Lucie Delemotte SciLifeLab Fellow
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Advances in the Relationships Between Cow's Milk Protein Allergy and Gut Microbiota in Infants.
Yang Y, Li X, Yang Y, ..., Ji B, Wei Y
Front Microbiol 12 (-) 716667 [2021-08-16; online 2021-08-16]
Saeed Shoaie SciLifeLab Fellow
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ImSwitch: Generalizing microscope control in Python
Moreno X, Al-Kadhimi S, Alvelid J, Bodén A, Testa I
JOSS 6 (64) 3394 [2021-08-14; online 2021-08-14]
Ilaria Testa SciLifeLab Fellow
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Candidatus Methylumidiphilus Drives Peaks in Methanotrophic Relative Abundance in Stratified Lakes and Ponds Across Northern Landscapes.
Martin G, Rissanen AJ, Garcia SL, ..., Buck M, Peura S
Front Microbiol 12 (-) 669937 [2021-08-12; online 2021-08-12]
Sarahi Garcia SciLifeLab Fellow
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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.
Pagnon de la Vega M, Giedraitis V, Michno W, ..., Sehlin D, Ingelsson M
Sci Transl Med 13 (606) - [2021-08-11; online 2021-08-13]
SciLifeLab Fellow Wojciech Michno
DOI Crossref
Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC
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SciLifeLab Fellow Wojciech Michno
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Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology.
Kampen S, Duy Vo D, Zhang X, ..., Kihlberg J, Carlsson J
Angew. Chem. Int. Ed. Engl. 60 (33) 18022-18030 [2021-08-09; online 2021-07-16]
Jens Carlsson SciLifeLab Fellow
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Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out.
Soares RRG, Akhtar AS, Pinto IF, ..., Pelechano V, Russom A
Lab Chip 21 (15) 2932-2944 [2021-08-07; online 2021-06-11]
SciLifeLab Fellow Vicent Pelechano
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Genome assemblies of three closely related leaf beetle species (Galerucella spp.).
Yang X, Slotte T, Dainat J, Hambäck PA
G3 11 (8) - [2021-08-07; online 2021-12-02]
SciLifeLab Fellow Tanja Slotte
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Microbial retention and resistances in stormwater quality improvement devices treating road runoff
Liguori R, Rommel SH, Bengtsson-Palme J, Helmreich B, Wurzbacher C
FEMS Microbes 2 (-) - [2021-08-03; online 2021-07-22]
DDLS Fellow Johan Bengtsson-Palme
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The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.
Kanellis DC, Espinoza JA, Zisi A, ..., Lindström MS, Bartek J
Sci Adv 7 (32) - [2021-08-00; online 2021-08-04]
SciLifeLab Fellow Simon Elsässer
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Rpb4 and Puf3 imprint and post-transcriptionally control the stability of a common set of mRNAs in yeast.
Garrido-Godino AI, Gupta I, Gutiérrez-Santiago F, ..., Pelechano V, Navarro F
RNA Biol 18 (8) 1206-1220 [2021-08-00; online 2020-11-01]
SciLifeLab Fellow Vicent Pelechano
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PhyloFisher: A phylogenomic package for resolving eukaryotic relationships.
Tice AK, Žihala D, Pánek T, ..., Kolísko M, Brown MW
PLoS Biol. 19 (8) e3001365 [2021-08-00; online 2021-08-06]
Fabien Burki SciLifeLab Fellow
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In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer's disease model of differentiated neuroblastoma cell line.
Arslan ME, Türkez H, Mardinoğlu A
Int J Neurosci 131 (8) 745-754 [2021-08-00; online 2020-04-19]
Adil Mardinoglu SciLifeLab Fellow
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Getting a grip with kirigami
Teleki A, Artursson P
Nat. Mater. 20 (8) 1043-1044 [2021-08-00; online 2021-07-28]
Alexandra Teleki SciLifeLab Fellow
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Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells.
Urbančič I, Schiffelers L, Jenkins E, ..., Sezgin E, Eggeling C
FEBS Lett. 595 (16) 2127-2146 [2021-08-00; online 2021-07-07]
Erdinc Sezgin SciLifeLab Fellow
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ADP-ribosyltransferases, an update on function and nomenclature.
Lüscher B, Ahel I, Altmeyer M, ..., Zaja R, Ziegler M
FEBS J. - (-) - [2021-07-29; online 2021-07-29]
SciLifeLab Fellow Sebastian Deindl
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DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study.
Vrettou M, Yan L, Nilsson KW, ..., Nylander I, Comasco E
Sci Rep 11 (1) 15322 [2021-07-28; online 2021-07-28]
Erika Comasco SciLifeLab Fellow
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Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells.
Özdemir Ö, Marinelli L, Cacciatore I, ..., Mardinoglu A, Turkez H
Z Naturforsch C J Biosci 76 (7-8) 329-335 [2021-07-27; online 2020-09-05]
Adil Mardinoglu SciLifeLab Fellow
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Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep.
Vallianatou T, Lin W, Bèchet NB, ..., Lundgaard I, Globisch D
J. Cereb. Blood Flow Metab. - (-) 271678X211033358 [2021-07-22; online 2021-07-22]
Daniel Globisch SciLifeLab Fellow
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Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease.
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Int J Mol Sci 22 (14) - [2021-07-08; online 2021-07-08]
Olof Eriksson SciLifeLab Fellow
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Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis.
Kundu S, Ali MA, Handin N, ..., Globisch D, Sjöblom T
J. Exp. Clin. Cancer Res. 40 (1) 225 [2021-07-07; online 2021-07-07]
Daniel Globisch SciLifeLab Fellow
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iNetModels 2.0: an interactive visualization and database of multi-omics data.
Arif M, Zhang C, Li X, ..., Uhlen M, Mardinoglu A
Nucleic Acids Res. 49 (W1) W271-W276 [2021-07-02; online 2021-04-14]
Adil Mardinoglu SciLifeLab Fellow
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The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization
Hempel NJ, Merkl P, Knopp MM, ..., Sotiriou GA, Löbmann K
Molecules 26 (13) 4035 [2021-07-01; online 2021-07-01]
Alexandra Teleki SciLifeLab Fellow
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Editorial: NK-Myeloid Cell Interactions in the Tumor Microenvironment: Implications for Cancer Immunotherapy.
Wennerberg E, Lundqvist A, Mao Y, Mougiakakos D
Front Immunol 12 (-) 718844 [2021-07-01; online 2021-07-01]
SciLifeLab Fellow Yumeng Mao
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Simultaneous detection of SARS-CoV-2 and pandemic (H1N1) 2009 virus with real-time isothermal platform.
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Heliyon 7 (7) e07584 [2021-07-00; online 2021-07-15]
SciLifeLab Fellow Vicent Pelechano
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Safety Assessments of Nickel Boride Nanoparticles on the Human Pulmonary Alveolar Cells by Using Cell Viability and Gene Expression Analyses.
Türkez H, Arslan ME, Sönmez E, ..., Açikyildiz M, Mardinoğlu A
Biol Trace Elem Res 199 (7) 2602-2611 [2021-07-00; online 2020-09-09]
Adil Mardinoglu SciLifeLab Fellow
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STED and parallelized RESOLFT optical nanoscopy of the tubular endoplasmic reticulum and its mitochondrial contacts in neuronal cells.
Damenti M, Coceano G, Pennacchietti F, Bodén A, Testa I
Neurobiol. Dis. 155 (-) 105361 [2021-07-00; online 2021-04-12]
Ilaria Testa SciLifeLab Fellow
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Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples.
Kubik S, Marques AC, Xing X, ..., Willig A, Xu Z
Clin. Microbiol. Infect. 27 (7) 1036.e1-1036.e8 [2021-07-00; online 2021-04-02]
SciLifeLab Fellow Vicent Pelechano
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On the origin of the widespread self-compatible allotetraploid Capsella bursa-pastoris (Brassicaceae).
Bachmann JA, Tedder A, Fracassetti M, ..., Köhler C, Slotte T
Heredity (Edinb) 127 (1) 124-134 [2021-07-00; online 2021-04-19]
SciLifeLab Fellow Tanja Slotte
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Molecular Dynamics Simulations of Ion Channels.
Carnevale V, Delemotte L, Howard RJ
Trends Biochem. Sci. 46 (7) 621-622 [2021-07-00; online 2021-04-30]
Lucie Delemotte SciLifeLab Fellow
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Effects of 6 weeks of treatment with dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, on myocardial function and metabolism in patients with type 2 diabetes: A randomized, placebo-controlled, exploratory study.
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Diabetes Obes Metab 23 (7) 1505-1517 [2021-07-00; online 2021-03-12]
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Environ Int 152 (-) 106488 [2021-07-00; online 2021-03-10]
Oskar Karlsson SciLifeLab Fellow
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DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design.
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Erik Benson SciLifeLab Fellow
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Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.
Kaltsouni E, Fisher PM, Dubol M, ..., Comasco E, Sundström-Poromaa I
Neuropsychopharmacology 46 (8) 1460-1467 [2021-07-00; online 2021-04-29]
Erika Comasco SciLifeLab Fellow
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DNA Blocks the Lethal Effect of Human Beta-Defensin 2 Against Neisseria meningitidis.
Wassing GM, Lidberg K, Sigurlásdóttir S, ..., Jonas K, Jonsson AB
Front Microbiol 12 (-) 697232 [2021-06-30; online 2021-06-30]
Kristina Jonas SciLifeLab Fellow
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Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients.
Van Wigcheren GF, De Haas N, Mulder TA, ..., Hato SV, De Vries IJM
Oncoimmunology 10 (1) 1935557 [2021-06-27; online 2021-06-27]
SciLifeLab Fellow Yumeng Mao
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Pesticide-induced multigenerational effects on amphibian reproduction and metabolism.
Karlsson O, Svanholm S, Eriksson A, ..., Jernerén F, Berg C
Sci. Total Environ. 775 (-) 145771 [2021-06-25; online 2021-02-11]
Oskar Karlsson SciLifeLab Fellow
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Accelerated regression-based summary statistics for discrete stochastic systems via approximate simulators.
Jiang RM, Wrede F, Singh P, Hellander A, Petzold LR
BMC Bioinformatics 22 (1) 339 [2021-06-23; online 2021-06-23]
Prashant Singh SciLifeLab Fellow
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The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles
Hempel NJ, Merkl P, Knopp MM, ..., Sotiriou GA, Löbmann K
Pharmaceutics 13 (6) 917 [2021-06-21; online 2021-06-21]
Alexandra Teleki SciLifeLab Fellow
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Application of high-throughput 5'P sequencing for the study of co-translational mRNA decay.
Zhang Y, Pelechano V
STAR Protoc 2 (2) 100447 [2021-06-18; online 2021-03-31]
SciLifeLab Fellow Vicent Pelechano
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Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.
Roxhed N, Bendes A, Dale M, ..., Fredolini C, Schwenk JM
Nat Commun 12 (1) 3695 [2021-06-17; online 2021-06-17]
SciLifeLab Fellow Simon Elsässer
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Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?
Rodriguez-Calvo T, Christoffersson G, Bender C, ..., Kent SC, James EA
Front Immunol 12 (-) 683091 [2021-06-16; online 2021-06-16]
Gustaf Christoffersson SciLifeLab Fellow
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Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling.
Wendt M, Bellavita R, Gerber A, ..., Hennig S, Grossmann TN
Angew. Chem. Int. Ed. Engl. 60 (25) 13937-13944 [2021-06-14; online 2021-05-05]
DDLS Fellow Nicholas Pearce
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Leveraging breeding programs and genomic data in Norway spruce (Picea abies L. Karst) for GWAS analysis.
Chen ZQ, Zan Y, Milesi P, ..., Lascoux M, Wu HX
Genome Biol. 22 (1) 179 [2021-06-13; online 2021-06-13]
Pascal Milesi SciLifeLab Fellow
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Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet
Hempel NJ, Merkl P, Asad S, ..., Sotiriou GA, Löbmann K
Mol. Pharmaceutics 18 (6) 2254-2262 [2021-06-07; online 2021-05-05]
Alexandra Teleki SciLifeLab Fellow
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The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.
Oftedal BE, Maio S, Handel AE, ..., Maizels RM, Holländer GA
Commun Biol 4 (1) 681 [2021-06-03; online 2021-06-03]
Erdinc Sezgin SciLifeLab Fellow
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Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes.
Eriksson O, Velikyan I, Haack T, ..., Tillner J, Wagner M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 62 (6) 833-838 [2021-06-01; online 2020-10-23]
Olof Eriksson SciLifeLab Fellow
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Unboxing mutations: Connecting mutation types with evolutionary consequences.
Berdan EL, Blanckaert A, Slotte T, ..., Westram AM, Fragata I
Mol. Ecol. 30 (12) 2710-2723 [2021-06-00; online 2021-05-19]
SciLifeLab Fellow Tanja Slotte
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Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being.
Pesic M, Egamberdieva D, Kolodziejczyk B, ..., Neergheen VS, Kagansky A
Biol Futur 72 (2) 119-125 [2021-06-00; online 2020-09-07]
SciLifeLab Fellow Simon Elsässer
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More Than Just Letters and Chemistry: Genomics Goes Mechanics.
Deindl S, Elf J
Trends Biochem. Sci. 46 (6) 431-432 [2021-06-00; online 2021-04-12]
SciLifeLab Fellow Sebastian Deindl
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Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics.
Michno W, Stringer KM, Enzlein T, ..., Edwards FA, Hanrieder J
Sci Adv 7 (25) - [2021-06-00; online 2021-06-16]
SciLifeLab Fellow Wojciech Michno
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Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides.
Muntjewerff EM, Tang K, Lutter L, ..., van den Bogaart G, Mahata SK
Acta Physiol 232 (2) e13655 [2021-06-00; online 2021-05-06]
Gustaf Christoffersson SciLifeLab Fellow
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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source.
Douangamath A, Powell A, Fearon D, ..., Gorrie-Stone T, von Delft F
J Vis Exp - (171) - [2021-05-29; online 2021-05-29]
DDLS Fellow Nicholas Pearce
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Using TIF-Seq2 to investigate association between 5´ and 3´mRNA ends.
Li B, Marques S, Wang J, Pelechano V
Meth. Enzymol. 655 (-) 85-118 [2021-05-28; online 2021-05-28]
SciLifeLab Fellow Vicent Pelechano
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Perivascular Macrophages Regulate Blood Flow Following Tissue Damage.
Vågesjö E, Parv K, Ahl D, ..., Christoffersson G, Phillipson M
Circ. Res. 128 (11) 1694-1707 [2021-05-28; online 2021-04-21]
Gustaf Christoffersson SciLifeLab Fellow
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Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas.
Parv K, Westerlund N, Merchant K, ..., Lindsay RS, Christoffersson G
Front Endocrinol (Lausanne) 12 (-) 606175 [2021-05-25; online 2021-05-25]
Gustaf Christoffersson SciLifeLab Fellow
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Genomic basis of parallel adaptation varies with divergence in Arabidopsis and its relatives.
Bohutínská M, Vlček J, Yair S, ..., Slotte T, Kolář F
Proc. Natl. Acad. Sci. U.S.A. 118 (21) - [2021-05-25; online 2021-05-19]
SciLifeLab Fellow Tanja Slotte
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A combined approach for single-cell mRNA and intracellular protein expression analysis.
Reimegård J, Tarbier M, Danielsson M, ..., Friedländer MR, Gallant CJ
Commun Biol 4 (1) 624 [2021-05-25; online 2021-05-25]
Marc Friedländer SciLifeLab Fellow
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Microbial Community Interactions Are Sensitive to Small Changes in Temperature.
Burman E, Bengtsson-Palme J
Front Microbiol 12 (-) 672910 [2021-05-21; online 2021-05-21]
DDLS Fellow Johan Bengtsson-Palme
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The human exposome and health in the Anthropocene.
Karlsson O, Rocklöv J, Lehoux AP, ..., Blunt MJ, Birnbaum LS
Int J Epidemiol 50 (2) 378-389 [2021-05-17; online 2020-12-23]
Oskar Karlsson SciLifeLab Fellow
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Phylogenomic Insights into the Origin of Primary Plastids.
Irisarri I, Strassert JFH, Burki F
Syst. Biol. - (-) - [2021-05-14; online 2021-05-14]
Fabien Burki SciLifeLab Fellow
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Comprehensive dataset of shotgun metagenomes from oxygen stratified freshwater lakes and ponds.
Buck M, Garcia SL, Fernandez L, ..., Bertilsson S, Peura S
Sci Data 8 (1) 131 [2021-05-14; online 2021-05-14]
Sarahi Garcia SciLifeLab Fellow
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Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans.
Bosley JR, Björnson E, Zhang C, ..., Borén J, Mardinoglu A
Front. Pharmacol. 12 (-) 643179 [2021-05-13; online 2021-05-13]
Adil Mardinoglu SciLifeLab Fellow
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Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production
Kang D, Shoaie S, Jacquiod S, Sørensen SJ, Ledesma-Amaro R
Microorganisms 9 (5) 1042 [2021-05-12; online 2021-05-12]
Saeed Shoaie SciLifeLab Fellow
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Freshwater Chlorobia Exhibit Metabolic Specialization among Cosmopolitan and Endemic Populations.
Garcia SL, Mehrshad M, Buck M, ..., Greening C, Peura S
mSystems 6 (3) - [2021-05-11; online 2021-05-11]
Sarahi Garcia SciLifeLab Fellow
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The Genomic Architecture and Evolutionary Fates of Supergenes.
Gutiérrez-Valencia J, Hughes PW, Berdan EL, Slotte T
Genome Biol Evol 13 (5) - [2021-05-07; online 2021-03-20]
SciLifeLab Fellow Tanja Slotte
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Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition.
Espeso-Gil S, Holik AZ, Bonnin S, ..., Hor CN, Ossowski S
Front Mol Neurosci 14 (-) 664912 [2021-05-05; online 2021-05-05]
Marc Friedländer SciLifeLab Fellow
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The Chaperonin GroESL Facilitates Caulobacter crescentus Cell Division by Supporting the Functions of the Z-Ring Regulators FtsA and FzlA.
Schroeder K, Heinrich K, Neuwirth I, Jonas K
MBio 12 (3) - [2021-05-04; online 2021-05-04]
Kristina Jonas SciLifeLab Fellow
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A microscopy-compatible temperature regulation system for single-cell phenotype analysis - demonstrated by thermoresponse mapping of microalgae.
Andersson M, Johansson S, Bergman H, ..., Behrendt L, Tenje M
Lab Chip 21 (9) 1694-1705 [2021-05-04; online 2021-05-06]
Lars Behrendt SciLifeLab Fellow
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Keeping up with the Bacillus cereus group: taxonomy through the genomics era and beyond.
Carroll LM, Cheng RA, Wiedmann M, Kovac J
Crit Rev Food Sci Nutr 62 (28) 7677-7702 [2021-05-03; online 2021-05-03]
DDLS Fellow Laura Carroll
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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.
Ghovanloo MR, Choudhury K, Bandaru TS, ..., Goodchild SJ, Ruben PC
J. Gen. Physiol. 153 (5) - [2021-05-03; online 2021-04-10]
Lucie Delemotte SciLifeLab Fellow
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Volumetric live cell imaging with three-dimensional parallelized RESOLFT microscopy.
Bodén A, Pennacchietti F, Coceano G, ..., Ratz M, Testa I
Nat. Biotechnol. 39 (5) 609-618 [2021-05-00; online 2021-01-11]
Ilaria Testa SciLifeLab Fellow
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Strategies for Constructing and Operating DNA Origami Linear Actuators.
Benson E, Carrascosa Marzo R, Bath J, Turberfield AJ
Small 17 (20) e2007704 [2021-05-00; online 2021-05-04]
Erik Benson SciLifeLab Fellow
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Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice.
Fattinger SA, Geiser P, Samperio Ventayol P, ..., Hardt WD, Sellin ME
Mucosal Immunol 14 (3) 615-629 [2021-05-00; online 2021-03-17]
Mikael Sellin SciLifeLab Fellow
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Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?
Kapla J, Rodríguez-Espigares I, Ballante F, Selent J, Carlsson J
PLoS Comput Biol 17 (5) e1008936 [2021-05-00; online 2021-05-13]
Jens Carlsson SciLifeLab Fellow
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The Protein Quality Control Network in Caulobacter crescentus.
Schroeder K, Jonas K
Front Mol Biosci 8 (-) 682967 [2021-04-30; online 2021-04-30]
Kristina Jonas SciLifeLab Fellow
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Informing NMR experiments with molecular dynamics simulations to characterize the dominant activated state of the KcsA ion channel.
Pérez-Conesa S, Keeler EG, Zhang D, Delemotte L, McDermott AE
J Chem Phys 154 (16) 165102 [2021-04-28; online 2021-05-05]
Lucie Delemotte SciLifeLab Fellow
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How Does Liquid-Liquid Phase Separation in Model Membranes Reflect Cell Membrane Heterogeneity?
Sych T, Gurdap CO, Wedemann L, Sezgin E
Membranes (Basel) 11 (5) - [2021-04-28; online 2021-04-28]
Erdinc Sezgin SciLifeLab Fellow
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Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers.
Samperio Ventayol P, Geiser P, Di Martino ML, ..., Eriksson J, Sellin ME
Proc. Natl. Acad. Sci. U.S.A. 118 (16) - [2021-04-20; online 2021-04-14]
Mikael Sellin SciLifeLab Fellow
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Scalable machine learning-assisted model exploration and inference using Sciope.
Singh P, Wrede F, Hellander A
Bioinformatics 37 (2) 279-281 [2021-04-19; online 2020-07-25]
Prashant Singh SciLifeLab Fellow
PubMed DOI Crossref
PET Imaging of GPR44 by Antagonist [11C]MK-7246 in Pigs.
Cheung P, Zhang B, Puuvuori E, ..., Eriksson J, Eriksson O
Biomedicines 9 (4) - [2021-04-16; online 2021-04-16]
Olof Eriksson SciLifeLab Fellow
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Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions.
Vihervaara A, Mahat DB, Himanen SV, ..., Lis JT, Sistonen L
Mol. Cell 81 (8) 1715-1731.e6 [2021-04-15; online 2021-03-29]
Anniina Vihervaara SciLifeLab Fellow
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A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation.
Regadas I, Dahlberg O, Vaid R, ..., Wen J, Mannervik M
Mol. Cell 81 (8) 1766-1780.e10 [2021-04-15; online 2021-02-24]
SciLifeLab Fellow Sebastian Deindl
PubMed DOI Crossref
DNA methylation in cord blood in association with prenatal depressive symptoms.
Kallak TK, Bränn E, Fransson E, ..., Lyle R, Skalkidou A
Clin Epigenetics 13 (1) 78 [2021-04-12; online 2021-04-12]
Erika Comasco SciLifeLab Fellow
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Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel.
Silverå Ejneby M, Gromova A, Ottosson NE, ..., Elinder F, Delemotte L
J. Gen. Physiol. 153 (4) - [2021-04-05; online 2021-03-09]
Lucie Delemotte SciLifeLab Fellow
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Genome Size Reduction and Transposon Activity Impact tRNA Gene Diversity While Ensuring Translational Stability in Birds.
Ottenburghs J, Geng K, Suh A, Kutter C
Genome Biol Evol 13 (4) - [2021-04-05; online 2021-02-04]
Claudia Kutter SciLifeLab Fellow
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High-throughput 5′P sequencing enables the study of degradation-associated ribosome stalls
Zhang Y, Pelechano V
Cell Reports Methods 1 (1) 100001 [2021-04-02]
SciLifeLab Fellow Vicent Pelechano
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The genome of Draba nivalis shows signatures of adaptation to the extreme environmental stresses of the Arctic.
Nowak MD, Birkeland S, Mandáková T, ..., Lysak MA, Brochmann C
Mol Ecol Resour 21 (3) 661-676 [2021-04-00; online 2020-11-12]
SciLifeLab Fellow Tanja Slotte
PubMed DOI Crossref
Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes.
Espes D, Carlsson PO, Selvaraju RK, ..., Korsgren O, Eriksson O
Diabetes 70 (4) 966-975 [2021-04-00; online 2021-01-21]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography.
Manell E, Puuvuori E, Svensson A, ..., Jensen Waern M, Eriksson O
BMJ Open Diabetes Res Care 9 (1) - [2021-04-00; online 2021-04-28]
Olof Eriksson SciLifeLab Fellow
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Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography.
Eriksson O, Velikyan I, Haack T, ..., Pierrou S, Wagner M
Diabetes 70 (4) 842-853 [2021-04-00; online 2021-02-05]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
A genomic catalog of Earth's microbiomes.
Nayfach S, Roux S, Seshadri R, ..., Kyrpides NC, Eloe-Fadrosh EA
Nat. Biotechnol. 39 (4) 499-509 [2021-04-00; online 2020-11-09]
Sarahi Garcia SciLifeLab Fellow
PubMed DOI Crossref
A molecular timescale for eukaryote evolution with implications for the origin of red algal-derived plastids.
Strassert JFH, Irisarri I, Williams TA, Burki F
Nat Commun 12 (1) 1879 [2021-03-25; online 2021-03-25]
Fabien Burki SciLifeLab Fellow
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Addressing the heterogeneity in liver diseases using biological networks.
Lam S, Doran S, Yuksel HH, ..., Uhlen M, Mardinoglu A
Brief. Bioinformatics 22 (2) 1751-1766 [2021-03-22; online 2020-03-24]
Adil Mardinoglu SciLifeLab Fellow
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Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar.
Bostanci N, Krog MC, Hugerth LW, ..., Nielsen HS, Schuppe-Koistinen I
Front. Cell. Infect. Microbiol. 11 (-) 625229 [2021-03-19; online 2021-03-19]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
The GenTree Platform: growth traits and tree-level environmental data in 12 European forest tree species.
Opgenoorth L, Dauphin B, Benavides R, ..., Aravanopoulos FA, Cavers S
Gigascience 10 (3) - [2021-03-18; online 2021-03-19]
Pascal Milesi SciLifeLab Fellow
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High Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7.
Jin X, Fu W, Li D, ..., Kutter C, Li Y
Onco Targets Ther 14 (-) 1753-1769 [2021-03-08; online 2021-03-08]
Claudia Kutter SciLifeLab Fellow
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Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25+ /CD54+ NK cells.
Chen Z, Yang Y, Neo SY, ..., Sarhan D, Lundqvist A
EMBO Rep. 22 (3) e51329 [2021-03-03; online 2021-01-22]
SciLifeLab Fellow Yumeng Mao
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ZFP207 <i>controls pluripotency by multiple post-transcriptional mechanisms</i>
Malla S, Bhattarai DP, Melguizo-Sanchis D, ..., Kutter C, Aguilo F
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Claudia Kutter SciLifeLab Fellow
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Ulipristal Acetate for Treatment of Premenstrual Dysphoric Disorder: A Proof-of-Concept Randomized Controlled Trial
Comasco E, Kopp Kallner H, Bixo M, ..., Epperson CN, Sundström-Poromaa I
AJP 178 (3) 256-265 [2021-03-01; online 2021-03-01]
Erika Comasco SciLifeLab Fellow
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The GenTree Leaf Collection: Inter‐ and intraspecific leaf variation in seven forest tree species in Europe
Benavides R, Carvalho B, Bastias CC, ..., Fady B, Valladares F
Global Ecol. Biogeogr. 30 (3) 590-597 [2021-03-00; online 2021-01-06]
Pascal Milesi SciLifeLab Fellow
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Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease
Rosario D, Bidkhori G, Lee S, ..., Mardinoglu A, Shoaie S
Cell Reports 34 (9) 108807 [2021-03-00; online 2021-03-00]
Saeed Shoaie SciLifeLab Fellow
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No evidence for a placental microbiome in human pregnancies at term.
Sterpu I, Fransson E, Hugerth LW, ..., Wiberg-Itzel E, Schuppe-Koistinen I
Am J Obstet Gynecol 224 (3) 296.e1-296.e23 [2021-03-00; online 2020-08-29]
DDLS Fellow Luisa Hugerth
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3D-printing of solid lipid tablets from emulsion gels
Johannesson J, Khan J, Hubert M, Teleki A, Bergström CAS
Int J Pharm 597 (-) 120304 [2021-03-00; online 2021-03-00]
Alexandra Teleki SciLifeLab Fellow
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The Organelle in the Room: Under-annotated Mitochondrial Reads Bias Coral Microbiome Analysis
Sonett D, Brown T, Bengtsson-Palme J, Padilla-Gamiño JL, Zaneveld JR
bioRxiv preprint - (-) - [2021-02-24; online 2021-02-24]
DDLS Fellow Johan Bengtsson-Palme
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Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets.
Fang T, Alvelid J, Spratt J, ..., Testa I, Teixeira AI
ACS Nano 15 (2) 3441-3452 [2021-02-23; online 2021-02-08]
Ilaria Testa SciLifeLab Fellow
PubMed DOI Crossref
Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes.
Johansson H, Søndergaard JN, Jorns C, Kutter C, Ellis ECS
Front Endocrinol (Lausanne) 11 (-) 554922 [2021-02-22; online 2021-02-22]
Claudia Kutter SciLifeLab Fellow
PubMed DOI Crossref
Mechanism of membrane-tethered mitochondrial protein synthesis.
Itoh Y, Andréll J, Choi A, ..., Battersby BJ, Amunts A
Science (New York, N.Y.) 371 (6531) 846-849 [2021-02-19; online 2021-02-20]
Alexey Amunts SciLifeLab Fellow
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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Hewitt G, Borel V, Segura-Bayona S, ..., Deindl S, Boulton SJ
Mol. Cell 81 (4) 767-783.e11 [2021-02-18; online 2020-12-16]
SciLifeLab Fellow Sebastian Deindl
PubMed DOI Crossref
Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence.
Carrara F, Sengupta A, Behrendt L, Vardi A, Stocker R
Proc. Natl. Acad. Sci. U.S.A. 118 (5) - [2021-02-02; online 2021-01-27]
Lars Behrendt SciLifeLab Fellow
PubMed DOI Crossref
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics.
Mahdessian D, Cesnik AJ, Gnann C, ..., Sullivan DP, Lundberg E
Nature 590 (7847) 649-654 [2021-02-00; online 2021-02-24]
Adil Mardinoglu SciLifeLab Fellow
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Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1.
Rosestedt M, Velikyan I, Rosenström U, ..., Nordeman P, Eriksson O
Nucl. Med. Biol. 93 (-) 54-62 [2021-02-00; online 2020-11-28]
Olof Eriksson SciLifeLab Fellow
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Phylogenomics of the tropical plant family Ochnaceae using targeted enrichment of nuclear genes and 250+ taxa
Schneider JV, Jungcurt T, Cardoso D, ..., Berberich T, Zizka G
TAXON 70 (1) 48-71 [2021-02-00; online 2020-12-31]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Optofluidic Raman-activated cell sorting for targeted genome retrieval or cultivation of microbial cells with specific functions.
Lee KS, Pereira FC, Palatinszky M, ..., Wagner M, Stocker R
Nat Protoc 16 (2) 634-676 [2021-02-00; online 2020-12-11]
Lars Behrendt SciLifeLab Fellow
PubMed DOI Crossref
NGSpeciesID: DNA barcode and amplicon consensus generation from long-read sequencing data.
Sahlin K, Lim MCW, Prost S
Ecol Evol 11 (3) 1392-1398 [2021-02-00; online 2021-01-11]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Model membrane systems to reconstitute immune cell signaling.
Céspedes PF, Beckers D, Dustin ML, Sezgin E
FEBS J. 288 (4) 1070-1090 [2021-02-00; online 2020-08-03]
Erdinc Sezgin SciLifeLab Fellow
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Hybrid seed incompatibility in Capsella is connected to chromatin condensation defects in the endosperm.
Dziasek K, Simon L, Lafon-Placette C, ..., Slotte T, Köhler C
PLoS Genet 17 (2) e1009370 [2021-02-00; online 2021-02-11]
SciLifeLab Fellow Tanja Slotte
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Epithelial inflammasomes in the defense against Salmonella gut infection.
Fattinger SA, Sellin ME, Hardt WD
Curr Opin Microbiol 59 (-) 86-94 [2021-02-00; online 2020-10-28]
Mikael Sellin SciLifeLab Fellow
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Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
Jain A, Correia MSP, Meistermann H, ..., Löhr JM, Globisch D
J Pharm Biomed Anal 195 (-) 113818 [2021-02-00; online 2021-02-00]
Daniel Globisch SciLifeLab Fellow
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Character and environmental lability of cyanobacteria‐derived dissolved organic matter
Patriarca C, Sedano‐Núñez VT, Garcia SL, ..., Tranvik LJ, Hawkes JA
Limnol. Oceanogr. 66 (2) 496-509 [2021-02-00; online 2020-10-09]
Sarahi Garcia SciLifeLab Fellow
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Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia
Harzandi A, Lee S, Bidkhori G, ..., Shoaie S, Sharpe CC
iScience 24 (2) 102046 [2021-02-00; online 2021-02-00]
Saeed Shoaie SciLifeLab Fellow
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<i>iucn_sim</i> : a new program to simulate future extinctions based on IUCN threat status
Andermann T, Faurby S, Cooke R, Silvestro D, Antonelli A
Ecography 44 (2) 162-176 [2021-02-00; online 2020-11-10]
DDLS Fellow Tobias Andermann
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Epidemiological modeling in StochSS Live!
Jiang R, Jacob B, Geiger M, ..., Hellander A, Petzold L
Bioinformatics - (-) - [2021-01-29; online 2021-01-29]
Prashant Singh SciLifeLab Fellow
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Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling.
Fleetwood O, Carlsson J, Delemotte L
Elife 10 (-) - [2021-01-28; online 2021-01-28]
Jens Carlsson Lucie Delemotte SciLifeLab Fellow
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Cellocity: A Python package for analysis of confluent cell layer dynamics
Eriksson J, Styrström D, Sellin M
JOSS 6 (57) 2818 [2021-01-28; online 2021-01-28]
Mikael Sellin SciLifeLab Fellow
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Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers.
Li X, Kim W, Arif M, ..., Zhang C, Mardinoglu A
Cancers (Basel) 13 (2) - [2021-01-19; online 2021-01-19]
Adil Mardinoglu SciLifeLab Fellow
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Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.
Alekseenko A, Barrett D, Pareja-Sanchez Y, ..., Yin X, Pelechano V
Sci Rep 11 (1) 1820 [2021-01-19; online 2021-01-19]
SciLifeLab Fellow Simon Elsässer Vicent Pelechano
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Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse.
Felce JH, Parolini L, Sezgin E, ..., Frater J, Dustin ML
Front Cell Dev Biol 8 (-) 608484 [2021-01-18; online 2021-01-18]
Erdinc Sezgin SciLifeLab Fellow
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Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis.
Ozalp O, Cark O, Azbazdar Y, ..., Sezgin E, Ozhan G
Biomolecules 11 (1) - [2021-01-14; online 2021-01-14]
Erdinc Sezgin SciLifeLab Fellow
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Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids.
Geiser P, Di Martino ML, Samperio Ventayol P, ..., Hellström PM, Sellin ME
MBio 12 (1) - [2021-01-12; online 2021-01-12]
Mikael Sellin SciLifeLab Fellow
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A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae.
Rodríguez-Galán O, García-Gómez JJ, Rosado IV, ..., Kressler D, de la Cruz J
Nucleic Acids Res. 49 (1) 206-220 [2021-01-11; online 2020-12-18]
SciLifeLab Fellow Vicent Pelechano
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Obese mother offspring have hepatic lipidic modulation that contributes to sex-dependent metabolic adaptation later in life.
Savva C, Helguero LA, González-Granillo M, ..., Kutter C, Korach-André M
Commun Biol 4 (1) 14 [2021-01-04; online 2021-01-04]
Claudia Kutter SciLifeLab Fellow
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Error correction enables use of Oxford Nanopore technology for reference-free transcriptome analysis.
Sahlin K, Medvedev P
Nat Commun 12 (1) 2 [2021-01-04; online 2021-01-04]
Kristoffer Sahlin SciLifeLab Fellow
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CAFE: a software suite for analysis of paired-sample transposon insertion sequencing data.
Abramova A, Osińska A, Kunche H, Burman E, Bengtsson-Palme J
Bioinformatics - (-) - [2021-01-04; online 2021-01-04]
DDLS Fellow Johan Bengtsson-Palme
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The effect of Toll-like receptor stimulation on the motility of regulatory T cells.
Chodaczek G, Pagni PP, Christoffersson G, ..., Wegrzyn AS, von Herrath M
J. Autoimmun. 116 (-) 102563 [2021-01-00; online 2020-11-12]
Gustaf Christoffersson SciLifeLab Fellow
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Systems biology based drug repositioning for development of cancer therapy.
Turanli B, Altay O, Borén J, ..., Arga KY, Mardinoglu A
Semin. Cancer Biol. 68 (-) 47-58 [2021-01-00; online 2019-09-27]
Adil Mardinoglu SciLifeLab Fellow
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Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease.
Asad S, Wegler C, Ahl D, ..., Artursson P, Teleki A
J Pharm Sci 110 (1) 239-250 [2021-01-00; online 2020-11-04]
Alexandra Teleki SciLifeLab Fellow
PubMed DOI Crossref
News ways of understanding the complex biology of diabetes using PET.
Eriksson O, Långström B, Antoni G
Nucl. Med. Biol. 92 (-) 65-71 [2021-01-00; online 2020-04-27]
Olof Eriksson SciLifeLab Fellow
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Neuroimaging the menstrual cycle: A multimodal systematic review.
Dubol M, Epperson CN, Sacher J, ..., Sundström-Poromaa I, Comasco E
Front Neuroendocrinol 60 (-) 100878 [2021-01-00; online 2020-10-22]
Erika Comasco SciLifeLab Fellow
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JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.
Stebbing J, Sánchez Nievas G, Falcone M, ..., Abizanda P, Lauschke VM
Sci Adv 7 (1) - [2021-01-00; online 2021-01-01]
Claudia Kutter SciLifeLab Fellow
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Ligand design by targeting a binding site water
Matricon P, Suresh RR, Gao ZG, ..., Jacobson KA, Carlsson J
Chem Sci 12 (3) 960-968 [2021-00-00; online 2021-00-00]
Jens Carlsson SciLifeLab Fellow
DOI Crossref
Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
Correia MSP, Thapa B, Vujasinovic M, Löhr JM, Globisch D
RSC Adv. 11 (55) 34788-34794 [2021-00-00; online 2021-00-00]
Daniel Globisch SciLifeLab Fellow
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5´XP sRNA-seq: efficient identification of transcripts with and without 5´ phosphorylation reveals evolutionary conserved small RNA.
Kugelberg U, Nätt D, Skog S, Kutter C, Öst A
RNA Biol - (-) 1-12 [2020-12-31; online 2020-12-31]
Claudia Kutter SciLifeLab Fellow
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Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Lehmann LC, Bacic L, Hewitt G, ..., Boulton SJ, Deindl S
Cell Reports 33 (12) 108529 [2020-12-22; online 2020-12-29]
SciLifeLab Fellow Sebastian Deindl
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Ileocolonic Histopathological and Microbial Alterations in the Irritable Bowel Syndrome: A Nested Community Case-Control Study.
Talley NJ, Alexander JL, Walker MM, ..., Powell N, Andreasson A
Clin Transl Gastroenterol 12 (1) e00296 [2020-12-22; online 2020-12-22]
DDLS Fellow Luisa Hugerth
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Ancient microRNA profiles of a 14,300-year-old canid samples confirm taxonomic origin and give glimpses into tissue-specific gene regulation from the Pleistocene.
Fromm B, Tarbier M, Smith O, ..., Gilbert TP, Friedlander MR
RNA - (-) - [2020-12-15; online 2020-12-15]
Marc Friedländer SciLifeLab Fellow
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Automated Removal of Non-homologous Sequence Stretches with PREQUAL.
Irisarri I, Burki F, Whelan S
Methods in molecular biology (Clifton, N.J.) 2231 (-) 147-162 [2020-12-09; online 2020-12-09]
Fabien Burki SciLifeLab Fellow
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Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.
Malkani S, Chin CR, Cekanaviciute E, ..., Mason CE, Beheshti A
Cell Reports 33 (10) 108448 [2020-12-08; online 2020-11-25]
Marc Friedländer SciLifeLab Fellow
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Microbial model communities: To understand complexity, harness the power of simplicity.
Bengtsson-Palme J
Comput Struct Biotechnol J 18 (-) 3987-4001 [2020-12-02; online 2020-12-02]
DDLS Fellow Johan Bengtsson-Palme
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Recent advances in single-molecule fluorescence microscopy render structural biology dynamic
Bacic L, Sabantsev A, Deindl S
Current Opinion in Structural Biology 65 (-) 61-68 [2020-12-00; online 2020-12-00]
SciLifeLab Fellow Sebastian Deindl
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Genome-wide detection of DNA double-strand breaks by in-suspension BLISS.
Bouwman BAM, Agostini F, Garnerone S, ..., Roukos V, Crosetto N
Nat Protoc 15 (12) 3894-3941 [2020-12-00; online 2020-11-02]
Magda Bienko SciLifeLab Fellow
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Distinct pre-initiation steps in human mitochondrial translation
Khawaja A, Itoh Y, Remes C, ..., Amunts A, Rorbach J
Nat Commun 11 (1) - [2020-12-00; online 2020-06-10]
Alexey Amunts SciLifeLab Fellow
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Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening.
Kang PW, Westerlund AM, Shi J, ..., Delemotte L, Cui J
Sci Adv 6 (50) - [2020-12-00; online 2020-12-11]
Lucie Delemotte SciLifeLab Fellow
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Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi
Itoh Y, Naschberger A, Mortezaei N, Herrmann JM, Amunts A
Nat Commun 11 (1) - [2020-12-00; online 2020-10-14]
Alexey Amunts SciLifeLab Fellow
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Universal Single-Residue Terminal Labels for Fluorescent Live Cell Imaging of Microproteins.
Lafranchi L, Schlesinger D, Kimler KJ, Elsässer SJ
Journal of the American Chemical Society 142 (47) 20080-20087 [2020-11-25; online 2020-11-11]
SciLifeLab Fellow Simon Elsässer
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Improved computational analysis of ribosome dynamics from 5′P degradome data using fivepseq
Nersisyan L, Ropat M, Pelechano V
NAR Genomics and Bioinformatics 2 (4) - [2020-11-24; online 2020-11-24]
SciLifeLab Fellow Vicent Pelechano
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Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells.
Zhan C, Bidkhori G, Schwarz H, ..., Rockberg J, Chotteau V
iScience 23 (11) 101653 [2020-11-20; online 2020-10-07]
Adil Mardinoglu SciLifeLab Fellow
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Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host.
Correia MSP, Jain A, Alotaibi W, ..., Rodriguez-Mateos A, Globisch D
Free Radic. Biol. Med. 160 (-) 745-754 [2020-11-20; online 2020-09-11]
Daniel Globisch SciLifeLab Fellow
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Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.
Nainytė M, Müller F, Ganazzoli G, ..., Globisch D, Carell T
Chemistry 26 (65) 14856-14860 [2020-11-20; online 2020-10-14]
Daniel Globisch SciLifeLab Fellow
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Assessment of In Vitro and In Silico Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome.
Hugerth LW, Pereira M, Zha Y, ..., Schuppe-Koistinen I, Engstrand L
mSphere 5 (6) - [2020-11-18; online 2020-11-18]
DDLS Fellow Luisa Hugerth
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Lipoprotein Particles Interact with Membranes and Transfer Their Cargo without Receptors
Plochberger B, Sych T, Weber F, ..., Stangl H, Sezgin E
Biochemistry 59 (45) 4421-4428 [2020-11-17; online 2020-11-04]
Erdinc Sezgin SciLifeLab Fellow
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Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes.
Danylchuk DI, Sezgin E, Chabert P, Klymchenko AS
Anal. Chem. 92 (21) 14798-14805 [2020-11-03; online 2020-10-12]
Erdinc Sezgin SciLifeLab Fellow
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Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images.
Enzlein T, Cordes J, Munteanu B, ..., Chávez-Gutiérrez L, Hopf C
Anal. Chem. 92 (21) 14484-14493 [2020-11-03; online 2020-10-14]
SciLifeLab Fellow Wojciech Michno
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Tracking the motion of the KV 1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy.
Pantazis A, Kaneko M, Angelini M, ..., Saitta SC, Olcese R
J. Physiol. (Lond.) 598 (22) 5245-5269 [2020-11-00; online 2020-09-21]
Lucie Delemotte SciLifeLab Fellow
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Quantification of aromatase binding in the female human brain using [11 C]cetrozole positron emission tomography.
Jonasson M, Nordeman P, Eriksson J, ..., Lubberink M, Comasco E
J Neurosci Res 98 (11) 2208-2218 [2020-11-00; online 2020-08-06]
Erika Comasco SciLifeLab Fellow
PubMed DOI Crossref
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and promote human breast cell carcinogenesis in vitro.
Pierozan P, Cattani D, Karlsson O
Arch. Toxicol. 94 (11) 3893-3906 [2020-11-00; online 2020-07-22]
Oskar Karlsson SciLifeLab Fellow
DOI Crossref
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F
Oosterheert W, Xenaki KT, Neviani V, ..., van Bergen en Henegouwen PM, Gros P
Life Sci. Alliance 3 (11) e202000883 [2020-11-00; online 2020-09-21]
DDLS Fellow Nicholas Pearce
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Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome
Ehrenbolger K, Jespersen N, Sharma H, ..., Vossbrinck CR, Barandun J
PLoS Biol. 18 (10) e3000958 [2020-10-30; online 2020-10-30]
Jonas Barandun SciLifeLab Fellow
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Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.
Yazici A, Marinelli L, Cacciatore I, ..., Mardinoğlu A, Türkez H
Curr Drug Deliv 18 (3) 350-356 [2020-10-29; online 2020-10-29]
Adil Mardinoglu SciLifeLab Fellow
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Fluidity and Lipid Composition of Membranes of Peroxisomes, Mitochondria and the ER From Oleic Acid-Induced Saccharomyces cerevisiae
Reglinski K, Steinfort-Effelsberg L, Sezgin E, ..., Eggeling C, Erdmann R
Front Cell Dev Biol 8 (-) 574363 [2020-10-29; online 2020-10-29]
Erdinc Sezgin SciLifeLab Fellow
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Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells.
Tarbier M, Mackowiak SD, Frade J, ..., Gallant CJ, Friedländer MR
Nat Commun 11 (1) 5445 [2020-10-28; online 2020-10-28]
Magda Bienko Marc Friedländer SciLifeLab Fellow
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Hippocampal neural stem cells are more susceptible to the neurotoxin BMAA than primary neurons: effects on apoptosis, cellular differentiation, neurite outgrowth, and DNA methylation.
Pierozan P, Cattani D, Karlsson O
Cell Death Dis 11 (10) 910 [2020-10-24; online 2020-10-24]
Oskar Karlsson SciLifeLab Fellow
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Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.
Flygaard RK, Mühleip A, Tobiasson V, Amunts A
Nat Commun 11 (1) 5342 [2020-10-22; online 2020-10-22]
Alexey Amunts SciLifeLab Fellow
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Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples.
Correia MSP, Lin W, Aria AJ, Jain A, Globisch D
Metabolites 10 (10) 415 [2020-10-16; online 2020-10-16]
Daniel Globisch SciLifeLab Fellow
PubMed
[11C]5-Hydroxy-tryptophan model for quantitative assessment of in vivo serotonin biosynthesis, retention and degradation in the endocrine pancreas.
Lubberink M, Eriksson O
American journal of nuclear medicine and molecular imaging 10 (5) 226-234 [2020-10-15; online 2020-10-15]
Olof Eriksson SciLifeLab Fellow
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Network analysis reveals how lipids and other cofactors influence membrane protein allostery.
Westerlund AM, Fleetwood O, Pérez-Conesa S, Delemotte L
J Chem Phys 153 (14) 141103 [2020-10-14; online 2020-10-23]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
TIF-Seq2 disentangles overlapping isoforms in complex human transcriptomes.
Wang J, Li B, Marques S, ..., Wei W, Pelechano V
Nucleic Acids Res. 48 (18) e104 [2020-10-09; online 2020-08-21]
SciLifeLab Fellow Vicent Pelechano
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An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.
Navarro C, Lyu J, Katsori AM, Caridha R, Elsässer SJ
Nat Commun 11 (1) 5095 [2020-10-09; online 2020-10-09]
SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes.
Eriksson O, Haack T, Hijazi Y, ..., Wagner M, Tillner J
Sci Rep 10 (1) 16758 [2020-10-07; online 2020-10-07]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella.
Dong Y, Majda M, Šimura J, ..., Smith RS, Østergaard L
Curr. Biol. 30 (19) 3880-3888.e5 [2020-10-05; online 2020-08-13]
SciLifeLab Fellow Tanja Slotte
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Progesterone - Friend or foe?
Sundström-Poromaa I, Comasco E, Sumner R, Luders E
Front Neuroendocrinol 59 (-) 100856 [2020-10-00; online 2020-07-28]
Erika Comasco SciLifeLab Fellow
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Male swarming aggregation pheromones increase female attraction and mating success among multiple African malaria vector mosquito species.
Mozūraitis R, Hajkazemian M, Zawada JW, ..., Borg-Karlson AK, Emami SN
Nat Ecol Evol 4 (10) 1395-1401 [2020-10-00; online 2020-08-03]
Marc Friedländer SciLifeLab Fellow
PubMed DOI Crossref
GPSeq reveals the radial organization of chromatin in the cell nucleus.
Girelli G, Custodio J, Kallas T, ..., Crosetto N, Bienko M
Nat. Biotechnol. 38 (10) 1184-1193 [2020-10-00; online 2020-05-25]
Magda Bienko SciLifeLab Fellow
PubMed DOI Crossref
Body composition after allogeneic haematopoietic cell transplantation/total body irradiation in children and young people: a restricted systematic review.
Lorenc A, Hamilton-Shield J, Perry R, Stevens M, CTYA HSCT Adipose and Muscle Late Effects Working Group
J Cancer Surviv 14 (5) 624-642 [2020-10-00; online 2020-07-18]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Streamlined and Abundant Bacterioplankton Thrive in Functional Cohorts.
Mondav R, Bertilsson S, Buck M, ..., Lindström ES, Garcia SL
mSystems 5 (5) - [2020-09-29; online 2020-09-29]
Sarahi Garcia SciLifeLab Fellow
PubMed DOI Crossref
Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.
Degorce SL, Tavana O, Banks E, ..., Yang B, Edmondson SD
J Med Chem 63 (18) 10460-10473 [2020-09-24; online 2020-09-14]
SciLifeLab Fellow Yumeng Mao
PubMed DOI Crossref
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning.
Mohammadi E, Benfeitas R, Turkez H, ..., Uhlen M, Mardinoglu A
Cancers (Basel) 12 (9) - [2020-09-21; online 2020-09-21]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals.
Vaga S, Lee S, Ji B, ..., Engstrand L, Shoaie S
Sci Rep 10 (1) 14977 [2020-09-11; online 2020-09-11]
Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Disease, Drugs and Dysbiosis: Understanding Microbial Signatures in Metabolic Disease and Medical Interventions.
Proffitt C, Bidkhori G, Moyes D, Shoaie S
Microorganisms 8 (9) 1381 [2020-09-09; online 2020-09-09]
Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Integration of molecular profiles in a longitudinal wellness profiling cohort.
Tebani A, Gummesson A, Zhong W, ..., Uhlen M, Fagerberg L
Nat Commun 11 (1) 4487 [2020-09-08; online 2020-09-08]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
The RNA exosome shapes the expression of key protein-coding genes.
Wu M, Karadoulama E, Lloret-Llinares M, ..., Jensen TH, Sandelin A
Nucleic Acids Res. 48 (15) 8509-8528 [2020-09-04; online 2020-07-28]
SciLifeLab Fellow Vicent Pelechano
PubMed DOI Crossref
Genome sequence of segmented filamentous bacteria present in the human intestine.
Jonsson H, Hugerth LW, Sundh J, Lundin E, Andersson AF
Commun Biol 3 (1) 485 [2020-09-04; online 2020-09-04]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
The past and future human impact on mammalian diversity.
Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D
Sci Adv 6 (36) - [2020-09-00; online 2020-09-04]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Systems Biology: A Multi-Omics Integration Approach to Metabolism and the Microbiome.
Son JW, Shoaie S, Lee S
Endocrinol Metab (Seoul) 35 (3) 507-514 [2020-09-00; online 2020-09-22]
Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
PhenoChip: A single-cell phenomic platform for high-throughput photophysiological analyses of microalgae.
Behrendt L, Salek MM, Trampe EL, ..., Kühl M, Stocker R
Sci Adv 6 (36) eabb2754 [2020-09-00; online 2020-09-02]
Lars Behrendt SciLifeLab Fellow
PubMed DOI Crossref
Perspectives from Ten Years of Protist Studies by High-Throughput Metabarcoding.
Santoferrara L, Burki F, Filker S, ..., Dunthorn M, McManus GB
J. Eukaryot. Microbiol. 67 (5) 612-622 [2020-09-00; online 2020-07-02]
Fabien Burki SciLifeLab Fellow
PubMed DOI Crossref
Structural basis of mitochondrial translation.
Aibara S, Singh V, Modelska A, Amunts A
Elife 9 (-) - [2020-08-19; online 2020-08-19]
Alexey Amunts SciLifeLab Fellow
PubMed DOI Crossref
Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2.
Conway LP, Rendo V, Correia MSP, ..., Sjöblom T, Globisch D
Angew. Chem. Int. Ed. Engl. 59 (34) 14342-14346 [2020-08-17; online 2020-07-08]
Daniel Globisch SciLifeLab Fellow
PubMed DOI Crossref
Drug Repositioning for P-Glycoprotein Mediated Co-Expression Networks in Colorectal Cancer.
Beklen H, Gulfidan G, Arga KY, Mardinoglu A, Turanli B
Front Oncol 10 (-) 1273 [2020-08-13; online 2020-08-13]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape.
Liang S, Ezerskyte M, Wang J, Pelechano V, Dreij K
Sci Rep 10 (1) 13513 [2020-08-11; online 2020-08-11]
SciLifeLab Fellow Vicent Pelechano
PubMed DOI Crossref
Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad.
Frawley AT, Wycisk V, Xiong Y, ..., Eggeling C, Anderson HL
Chem Sci 11 (33) 8955-8960 [2020-08-10; online 2020-08-10]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution.
Björkman A, Johansen SL, Lin L, ..., Bartek J, Schou KB
Genes Dev. 34 (15-16) 1065-1074 [2020-08-01; online 2020-06-19]
SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region.
Pierozan P, Piras E, Brittebo E, Karlsson O
Arch. Toxicol. 94 (8) 2799-2808 [2020-08-00; online 2020-05-20]
Oskar Karlsson SciLifeLab Fellow
PubMed DOI Crossref
Predatory colponemids are the sister group to all other alveolates.
Tikhonenkov DV, Strassert JFH, Janouškovec J, ..., Burki F, Keeling PJ
Mol. Phylogenet. Evol. 149 (-) 106839 [2020-08-00; online 2020-04-21]
Fabien Burki SciLifeLab Fellow
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Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis.
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Systems Biology Approaches to Understand the Host-Microbiome Interactions in Neurodegenerative Diseases.
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Pulsed Electric Fields Can Create Pores in the Voltage Sensors of Voltage-Gated Ion Channels.
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Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation.
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A systems biology approach for studying neurodegenerative diseases.
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Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women.
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Cell Reports 31 (12) 107808 [2020-06-23; online 2020-06-25]
Adil Mardinoglu SciLifeLab Fellow
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Site-Specific Incorporation of Two ncAAs for Two-Color Bioorthogonal Labeling and Crosslinking of Proteins on Live Mammalian Cells.
Meineke B, Heimgärtner J, Eirich J, Landreh M, Elsässer SJ
Cell Reports 31 (12) 107811 [2020-06-23; online 2020-06-25]
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Successful delivery of large-size CRISPR/Cas9 vectors in hard-to-transfect human cells using small plasmids.
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Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese men.
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Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation.
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Chaining with Overlaps Revisited
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Kristoffer Sahlin SciLifeLab Fellow
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Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification.
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Daniel Globisch SciLifeLab Fellow
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No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population.
Hugerth LW, Andreasson A, Talley NJ, ..., Agreus L, Engstrand L
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Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach.
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Integrating the "Immunome" in the Stratification of Myelodysplastic Syndromes and Future Clinical Trial Design.
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z-STED Imaging and Spectroscopy to Investigate Nanoscale Membrane Structure and Dynamics.
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Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates.
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Biomolecules 10 (5) 737 [2020-05-09; online 2020-05-09]
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Predicting resolution and image quality in RESOLFT and other point scanning microscopes [Invited].
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Differential Expression of Immune Genes between Two Closely Related Beetle Species with Different Immunocompetence following Attack by Asecodes parviclava.
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Genome Biol Evol 12 (5) 522-534 [2020-05-01; online 2020-04-14]
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Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium.
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PLoS Pathog 16 (5) e1008503 [2020-05-00; online 2020-05-04]
Mikael Sellin SciLifeLab Fellow
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Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression.
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Mucosal Immunol 13 (3) 530-544 [2020-05-00; online 2020-01-17]
Mikael Sellin SciLifeLab Fellow
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Genome-Scale Metabolic Modeling of Glioblastoma Reveals Promising Targets for Drug Development.
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Front Genet 11 (-) 381 [2020-04-17; online 2020-04-17]
Adil Mardinoglu SciLifeLab Fellow
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High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy.
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Erdinc Sezgin SciLifeLab Fellow
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The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.
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The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells
Çadirci K, Özdemir Tozlu Ö, Türkez H, Mardinoğlu A
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Pooled CRISPRi screening of the cyanobacterium Synechocystis sp PCC 6803 for enhanced industrial phenotypes.
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Nat Commun 11 (1) 1666 [2020-04-03; online 2020-04-03]
Paul Hudson SciLifeLab Fellow
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The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
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Mol Syst Biol 16 (4) e9495 [2020-04-00; online 2020-04-28]
Adil Mardinoglu SciLifeLab Fellow
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Neuroimaging premenstrual dysphoric disorder: A systematic and critical review.
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Front Neuroendocrinol 57 (-) 100838 [2020-04-00; online 2020-04-05]
Erika Comasco SciLifeLab Fellow
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De Novo Clustering of Long-Read Transcriptome Data Using a Greedy, Quality Value-Based Algorithm.
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Kristoffer Sahlin SciLifeLab Fellow
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An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models.
Choi MJ, Jung SB, Lee SE, ..., Yi HS, Shong M
Diabetologia 63 (4) 837-852 [2020-04-00; online 2020-01-10]
Adil Mardinoglu SciLifeLab Fellow
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An atlas of human metabolism.
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Sci Signal 13 (624) eaaz1482 [2020-03-24; online 2020-03-24]
Adil Mardinoglu SciLifeLab Fellow
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Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour.
Checknita D, Bendre M, Ekström TJ, ..., Hodgins S, Nilsson KW
Behav. Brain Res. 382 (-) 112476 [2020-03-16; online 2020-01-10]
Erika Comasco SciLifeLab Fellow
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An atlas of the protein-coding genes in the human, pig, and mouse brain.
Sjöstedt E, Zhong W, Fagerberg L, ..., Uhlén M, Mulder J
Science (New York, N.Y.) 367 (6482) eaay5947 [2020-03-06; online 2020-03-07]
Adil Mardinoglu SciLifeLab Fellow
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Structure of a minimal photosystem I from the green alga Dunaliella salina.
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Nat Plants 6 (3) 321-327 [2020-03-00; online 2020-03-02]
Alexey Amunts SciLifeLab Fellow
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Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity.
Jaiteh M, Rodríguez-Espigares I, Selent J, Carlsson J
PLoS Comput Biol 16 (3) e1007680 [2020-03-00; online 2020-03-13]
Jens Carlsson SciLifeLab Fellow
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MEMOTE for standardized genome-scale metabolic model testing.
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Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
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Long-read metabarcoding of the eukaryotic rDNA operon to phylogenetically and taxonomically resolve environmental diversity.
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Mol Ecol Resour 20 (2) 429-443 [2020-03-00; online 2019-11-29]
Fabien Burki SciLifeLab Fellow
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Life in the dark: far-red absorbing cyanobacteria extend photic zones deep into terrestrial caves.
Behrendt L, Trampe EL, Nord NB, ..., Hershey OS, Barton H
Environ. Microbiol. 22 (3) 952-963 [2020-03-00; online 2019-09-09]
Lars Behrendt SciLifeLab Fellow
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Distinct structural modulation of photosystem I and lipid environment stabilizes its tetrameric assembly.
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Nat Plants 6 (3) 314-320 [2020-03-00; online 2020-03-09]
Alexey Amunts SciLifeLab Fellow
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Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease.
Michno W, Wehrli P, Meier SR, ..., Blennow K, Hanrieder J
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Impact of Nanoscale Hindrances on the Relationship between Lipid Packing and Diffusion in Model Membranes.
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A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.
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Sci Rep 10 (1) 3637 [2020-02-27; online 2020-02-27]
Claudia Kutter SciLifeLab Fellow
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Energy Landscapes Reveal Agonist Control of G Protein-Coupled Receptor Activation via Microswitches.
Fleetwood O, Matricon P, Carlsson J, Delemotte L
Biochemistry 59 (7) 880-891 [2020-02-25; online 2020-02-07]
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A Guide to Carrying Out a Phylogenomic Target Sequence Capture Project.
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Front Genet 10 (-) 1407 [2020-02-21; online 2020-02-21]
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Creating Supported Plasma Membrane Bilayers Using Acoustic Pressure.
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Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Nav1.5.
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Molecules 25 (4) 902 [2020-02-18; online 2020-02-18]
Lucie Delemotte SciLifeLab Fellow
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Radial Organization in the Mammalian Nucleus.
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Magda Bienko SciLifeLab Fellow
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Nat Commun 11 (1) 756 [2020-02-06; online 2020-02-06]
Erdinc Sezgin SciLifeLab Fellow
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Molecular Insights from Conformational Ensembles via Machine Learning.
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Lucie Delemotte SciLifeLab Fellow
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Abundance and diversity of resistomes differ between healthy human oral cavities and gut.
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Nat Commun 11 (1) 693 [2020-02-04; online 2020-02-04]
Saeed Shoaie SciLifeLab Fellow
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Unification of miRNA and isomiR research: the mirGFF3 format and the mirtop API.
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Bioinformatics 36 (3) 698-703 [2020-02-01; online 2019-09-11]
Marc Friedländer SciLifeLab Fellow
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The molecular basis for sugar import in malaria parasites.
Qureshi AA, Suades A, Matsuoka R, ..., Delemotte L, Drew D
Nature 578 (7794) 321-325 [2020-02-00; online 2020-01-29]
Lucie Delemotte SciLifeLab Fellow
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Handling ties in continuous outcomes for confounder adjustment with rank-ordered logit and its application to ordinal outcomes.
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Stat Methods Med Res 29 (2) 437-454 [2020-02-00; online 2019-04-03]
Erika Comasco SciLifeLab Fellow
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Environmental impacts and limitations of third‐generation biobutanol: Life cycle assessment of n ‐butanol produced by genetically engineered cyanobacteria
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Journal of Industrial Ecology 24 (1) 205-216 [2020-02-00; online 2019-04-00]
Paul Hudson SciLifeLab Fellow
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Classification of clear cell renal cell carcinoma based on PKM alternative splicing.
Li X, Turanli B, Juszczak K, ..., Zhang C, Mardinoglu A
Heliyon 6 (2) e03440 [2020-02-00; online 2020-02-19]
Adil Mardinoglu SciLifeLab Fellow
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Phylogenomics and biogeography of the world's thrushes (Aves, Turdus): new evidence for a more parsimonious evolutionary history.
Batista R, Olsson U, Andermann T, ..., Ribas CC, Antonelli A
Proc. Biol. Sci. 287 (1919) 20192400 [2020-01-29; online 2020-01-22]
DDLS Fellow Tobias Andermann
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Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D.
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Front Immunol 11 (-) 40 [2020-01-28; online 2020-01-28]
Adil Mardinoglu SciLifeLab Fellow
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Population Genomics of Transitions to Selfing in Brassicaceae Model Systems.
Mattila TM, Laenen B, Slotte T
Methods in molecular biology (Clifton, N.J.) 2090 (-) 269-287 [2020-01-25; online 2020-01-25]
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Docking Finds GPCR Ligands in Dark Chemical Matter.
Ballante F, Rudling A, Zeifman A, ..., Loza MI, Carlsson J
J Med Chem 63 (2) 613-620 [2020-01-23; online 2020-01-13]
Jens Carlsson SciLifeLab Fellow
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Evidence of altered mucosa-associated and fecal microbiota composition in patients with Irritable Bowel Syndrome.
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Sci Rep 10 (1) 593 [2020-01-17; online 2020-01-17]
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Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
Pagoni A, Marinelli L, Di Stefano A, ..., Vassiliou S, Cacciatore I
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Adil Mardinoglu SciLifeLab Fellow
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A set of monomeric near-infrared fluorescent proteins for multicolor imaging across scales.
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Stable stimulated emission depletion imaging of extended sample regions
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Ilaria Testa SciLifeLab Fellow
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MirGeneDB 2.0: the metazoan microRNA complement.
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The GenTree Dendroecological Collection, tree-ring and wood density data from seven tree species across Europe.
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Kristina Jonas SciLifeLab Fellow
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Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics.
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The New Tree of Eukaryotes.
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Sari Peura SciLifeLab Fellow
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A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
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High genetic diversity but no geographical structure of Aedes albopictus populations in Réunion Island.
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A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart.
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Evolutionary Refinement of DNA Nanostructures Using Coarse-Grained Molecular Dynamics Simulations.
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Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
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Molecular imaging mass spectrometry for probing protein dynamics in neurodegenerative disease pathology.
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Chemometric Strategies for Sensitive Annotation and Validation of Anatomical Regions of Interest in Complex Imaging Mass Spectrometry Data.
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Association of PTHrP levels in CSF with Alzheimer's disease biomarkers.
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J Chem Inf Model 59 (10) 4093-4099 [2019-10-28; online 2019-10-11]
Lucie Delemotte SciLifeLab Fellow
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CUTseq is a versatile method for preparing multiplexed DNA sequencing libraries from low-input samples.
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Nat Commun 10 (1) 4732 [2019-10-18; online 2019-10-18]
Magda Bienko SciLifeLab Fellow
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Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates.
Eriksson O, Velikyan I, Haack T, ..., Pierrou S, Wagner M
Sci Rep 9 (1) 14960 [2019-10-18; online 2019-10-18]
Olof Eriksson SciLifeLab Fellow
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Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products.
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J. Alzheimers Dis. 72 (2) 537-548 [2019-10-15; online 2019-10-15]
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Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe.
Cardozo Pinto DF, Yang H, Pollak Dorocic I, ..., Smidt MP, Lammel S
Nat Commun 10 (1) 4633 [2019-10-11; online 2019-10-11]
Iskra Pollak Dorocic SciLifeLab Fellow
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Remodeling the genome with DNA twists.
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Science (New York, N.Y.) 366 (6461) 35-36 [2019-10-04; online 2019-10-12]
SciLifeLab Fellow Sebastian Deindl
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Industrial wastewater treatment plant enriches antibiotic resistance genes and alters the structure of microbial communities.
Bengtsson-Palme J, Milakovic M, Švecová H, ..., Grabic R, Udikovic-Kolic N
Water Res 162 (-) 437-445 [2019-10-01; online 2019-07-04]
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VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths.
Vrettou M, Nilsson KW, Tuvblad C, ..., Nylander I, Comasco E
Eur Child Adolesc Psychiatry 28 (10) 1329-1340 [2019-10-00; online 2019-02-25]
Erika Comasco SciLifeLab Fellow
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Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI.
Espes D, Manell E, Rydén A, ..., Jansson L, Eriksson O
Acta diabetologica 56 (10) 1113-1120 [2019-10-00; online 2019-04-26]
Olof Eriksson SciLifeLab Fellow
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Genetic basis and timing of a major mating system shift in Capsella.
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New Phytol. 224 (1) 505-517 [2019-10-00; online 2019-08-01]
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Association between Transcription Factor AP-2B genotype, obesity, insulin resistance and dietary intake in a longitudinal birth cohort study.
Joost U, Villa I, Comasco E, ..., Veidebaum T, Harro J
Int J Obes (Lond) 43 (10) 2095-2106 [2019-10-00; online 2019-06-17]
Erika Comasco SciLifeLab Fellow
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EvoChromo: towards a synthesis of chromatin biology and evolution.
Drinnenberg IA, Berger F, Elsässer SJ, ..., Warnecke T, Wolfe KH
Development 146 (19) - [2019-09-26; online 2019-09-26]
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Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1.
Masser AE, Kang W, Roy J, ..., Friedländer MR, Andréasson C
Elife 8 (-) - [2019-09-25; online 2019-09-25]
Marc Friedländer SciLifeLab Fellow
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What industry can teach academia.
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Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells.
Kumar B, Elsässer SJ
Cell Reports 28 (12) 3274-3284.e5 [2019-09-17; online 2019-09-19]
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Mechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density.
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Commun Biol 2 (-) 337 [2019-09-13; online 2019-09-13]
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Strategies to Reduce or Eliminate Resistant Pathogens in the Environment
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Antibiotic Drug Resistance - (-) 637-673 [2019-09-09; online 2019-08-23]
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Mumame: a software tool for quantifying gene-specific point-mutations in shotgun metagenomic data
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MBMG 3 (-) - [2019-09-04; online 2019-09-04]
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Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
van den Bos RM, Pearce NM, Granneman J, Brondijk THC, Gros P
Front Immunol 10 (-) 2097 [2019-09-04; online 2019-09-04]
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Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism.
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Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut.
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Nature 573 (7773) 276-280 [2019-09-00; online 2019-09-04]
Mikael Sellin SciLifeLab Fellow
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Investigation of the skin microbiome: swabs vs. biopsies.
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Ecol Evol 9 (17) 9532-9545 [2019-09-00; online 2019-08-13]
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Genomic data provide new insights on the demographic history and the extent of recent material transfers in Norway spruce.
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Evol Appl 12 (8) 1539-1551 [2019-09-00; online 2019-04-30]
Pascal Milesi SciLifeLab Fellow
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Erika Comasco SciLifeLab Fellow
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Turning Up the Heat: Local Temperature Control During in vivo Imaging of Immune Cells.
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Nanoscale dynamics of cholesterol in the cell membrane.
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J. Biol. Chem. 294 (34) 12599-12609 [2019-08-23; online 2019-07-03]
Erdinc Sezgin SciLifeLab Fellow
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Molecular Basis and Ecological Relevance of Caulobacter Cell Filamentation in Freshwater Habitats.
Heinrich K, Leslie DJ, Morlock M, Bertilsson S, Jonas K
MBio 10 (4) - [2019-08-20; online 2019-08-20]
Kristina Jonas SciLifeLab Fellow
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Progress towards the Tree of Eukaryotes.
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Curr. Biol. 29 (16) R808-R817 [2019-08-19; online 2019-08-21]
Fabien Burki SciLifeLab Fellow
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MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy.
Bugiardini E, Mitchell AL, Rosa ID, ..., Pitceathly RDS, Spinazzola A
Hum. Mol. Genet. 28 (16) 2711-2719 [2019-08-15; online 2019-05-01]
Alexey Amunts SciLifeLab Fellow
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LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.
Cadenas C, Vosbeck S, Edlund K, ..., Marchan R, Hengstler JG
Int. J. Cancer 145 (4) 901-915 [2019-08-15; online 2019-02-07]
Adil Mardinoglu SciLifeLab Fellow
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Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples.
Conway LP, Garg N, Lin W, ..., Löhr JM, Globisch D
Chem. Commun. (Camb.) 55 (62) 9080-9083 [2019-08-11; online 2019-07-09]
Daniel Globisch SciLifeLab Fellow
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DiscoverY: a classifier for identifying Y chromosome sequences in male assemblies.
Rangavittal S, Stopa N, Tomaszkiewicz M, ..., Makova KD, Medvedev P
BMC Genomics 20 (1) 641 [2019-08-09; online 2019-08-09]
Kristoffer Sahlin SciLifeLab Fellow
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The ribosomal protein S1-dependent standby site in tisB mRNA consists of a single-stranded region and a 5' structure element.
Romilly C, Deindl S, Wagner EGH
Proc. Natl. Acad. Sci. U.S.A. 116 (32) 15901-15906 [2019-08-06; online 2019-07-18]
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Tools for Bioimaging Pancreatic β Cells in Diabetes.
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Trends in molecular medicine 25 (8) 708-722 [2019-08-00; online 2019-06-06]
Olof Eriksson SciLifeLab Fellow
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Strategies for increasing the throughput of super-resolution microscopies.
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Curr Opin Chem Biol 51 (-) 84-91 [2019-08-00; online 2019-06-15]
Ilaria Testa SciLifeLab Fellow
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Single-cell expression noise and gene-body methylation in Arabidopsis thaliana.
Horvath R, Laenen B, Takuno S, Slotte T
Heredity (Edinb) 123 (2) 81-91 [2019-08-00; online 2019-01-16]
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Hypothalamic-pituitary-adrenal axis responsiveness, startle response, and sensorimotor gating in late pregnancy.
Breedh J, Comasco E, Hellgren C, ..., Skalkidou A, Poromaa IS
Psychoneuroendocrinology 106 (-) 1-8 [2019-08-00; online 2019-03-15]
Erika Comasco SciLifeLab Fellow
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Human prenatal exposure to polychlorinated biphenyls (PCBs) and risk behaviors in adolescence.
Dickerson AS, Ransome Y, Karlsson O
Environ Int 129 (-) 247-255 [2019-08-00; online 2019-05-27]
Oskar Karlsson SciLifeLab Fellow
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Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling.
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Front Oncol 9 (-) 681 [2019-07-30; online 2019-07-30]
Adil Mardinoglu SciLifeLab Fellow
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Amyloid fibril polymorphism and cell-specific toxicity in vivo.
Jonson M, Nyström S, Sandberg A, ..., Thor S, Hammarström P
Amyloid 26 (sup1) 136-137 [2019-07-26; online 2019-07-26]
SciLifeLab Fellow Wojciech Michno
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Constitutive Serotonin Transporter Reduction Resembles Maternal Separation with Regard to Stress-Related Gene Expression.
Comasco E, Schijven D, de Maeyer H, ..., Sundström-Poromaa I, Olivier JDA
ACS Chem Neurosci 10 (7) 3132-3142 [2019-07-17; online 2019-01-23]
Erika Comasco SciLifeLab Fellow
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The Potential Use of Metabolic Cofactors in Treatment of NAFLD.
Mardinoglu A, Ural D, Zeybel M, ..., Uhlén M, Borén J
Nutrients 11 (7) 1578 [2019-07-12; online 2019-07-12]
Adil Mardinoglu SciLifeLab Fellow
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Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nirwan N, Itoh Y, Singh P, ..., Amunts A, Saikrishnan K
Nat Commun 10 (1) 3058 [2019-07-11; online 2019-07-11]
Alexey Amunts SciLifeLab Fellow
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Coupled Enzymatic Treatment and Mass Spectrometric Analysis for Identification of Glucuronidated Metabolites in Human Samples.
Correia MSP, Rao M, Ballet C, Globisch D
Chembiochem 20 (13) 1678-1683 [2019-07-01; online 2019-05-08]
Daniel Globisch SciLifeLab Fellow
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Regulation of the replication initiator DnaA in Caulobacter crescentus.
Felletti M, Omnus DJ, Jonas K
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862 (7) 697-705 [2019-07-00; online 2018-01-31]
Kristina Jonas SciLifeLab Fellow
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Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs.
Sahebekhtiari N, Saraswat M, Joenväärä S, ..., Renkonen R, Pietiläinen KH
Proteomics Clin Appl 13 (4) e1800173 [2019-07-00; online 2019-02-05]
Adil Mardinoglu SciLifeLab Fellow
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Outlining the proton-conduction pathway in otopetrin channels.
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Nat. Struct. Mol. Biol. 26 (7) 528-530 [2019-07-00; online 2019-06-27]
Lucie Delemotte SciLifeLab Fellow
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Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Bigalke JM, Aibara S, Roth R, ..., Amunts A, Sandmark J
Sci Adv 5 (7) eaau4202 [2019-07-00; online 2019-07-31]
Alexey Amunts SciLifeLab Fellow
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The Next Generation of Pattern Recognition Receptor Agonists: Improving Response Rates in Cancer Immunotherapy.
O' Donovan DH, Mao Y, Mele DA
Current medicinal chemistry 27 (34) 5654-5674 [2019-06-30; online 2019-06-30]
SciLifeLab Fellow Yumeng Mao
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GPR44 as a Target for Imaging Pancreatic Beta-Cell Mass.
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Current diabetes reports 19 (8) 49 [2019-06-27; online 2019-06-27]
Olof Eriksson SciLifeLab Fellow
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Shotgun Environmental DNA, Pollen, and Macrofossil Analysis of Lateglacial Lake Sediments From Southern Sweden
Parducci L, Alsos IG, Unneberg P, ..., Slotte T, Wohlfarth B
Front. Ecol. Evol. 7 (-) - [2019-06-20; online 2019-06-20]
SciLifeLab Fellow Tanja Slotte
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Mitotically heritable effects of BMAA on striatal neural stem cell proliferation and differentiation.
Pierozan P, Karlsson O
Cell Death Dis 10 (7) 478 [2019-06-17; online 2019-06-17]
Oskar Karlsson SciLifeLab Fellow
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Conformational switches control early maturation of the eukaryotic small ribosomal subunit.
Hunziker M, Barandun J, Buzovetsky O, ..., Molina H, Klinge S
Elife 8 (-) - [2019-06-17; online 2019-06-17]
Jonas Barandun SciLifeLab Fellow
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Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity.
Ibrahim A, Hugerth LW, Hases L, ..., Engstrand L, Williams C
Int. J. Cancer 144 (12) 3086-3098 [2019-06-15; online 2019-01-11]
DDLS Fellow Luisa Hugerth
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RMetD2: a tool for integration of relative transcriptomics data into Genome-scale metabolic models
Zhang C, Lee S, Bidkhori G, ..., Nielsen J, Mardinoglu A
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Adil Mardinoglu SciLifeLab Fellow
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Regulatory Immune Mechanisms beyond Regulatory T Cells.
Christoffersson G, von Herrath M
Trends Immunol. 40 (6) 482-491 [2019-06-00; online 2019-05-14]
Gustaf Christoffersson SciLifeLab Fellow
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Growth-driven displacement of protein aggregates along the cell length ensures partitioning to both daughter cells in Caulobacter crescentus.
Schramm FD, Schroeder K, Alvelid J, Testa I, Jonas K
Mol. Microbiol. 111 (6) 1430-1448 [2019-06-00; online 2019-04-03]
Ilaria Testa Kristina Jonas SciLifeLab Fellow
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Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects.
Bergström CAS, Box K, Holm R, ..., Schäfer KJ, Teleki A
Eur J Pharm Biopharm 139 (-) 101-114 [2019-06-00; online 2019-03-09]
Alexandra Teleki SciLifeLab Fellow
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Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract.
Furter M, Sellin ME, Hansson GC, Hardt WD
Cell Reports 27 (9) 2665-2678.e3 [2019-05-28; online 2019-05-30]
Mikael Sellin SciLifeLab Fellow
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Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms.
Di Martino ML, Ek V, Hardt WD, Eriksson J, Sellin ME
MBio 10 (3) - [2019-05-21; online 2019-05-21]
Mikael Sellin SciLifeLab Fellow
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Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production.
Paivandy A, Eriksson J, Melo FR, Sellin ME, Pejler G
Cell death discovery 5 (1) 95 [2019-05-15; online 2019-05-15]
Mikael Sellin SciLifeLab Fellow
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EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks.
Domingo-Prim J, Endara-Coll M, Bonath F, ..., Huertas P, Visa N
Nat Commun 10 (1) 2135 [2019-05-13; online 2019-05-13]
Marc Friedländer SciLifeLab Fellow
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Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis.
Davanian H, Gaiser RA, Silfverberg M, ..., Engstrand L, Sällberg Chen M
Int J Oral Sci 11 (2) 16 [2019-05-09; online 2019-05-09]
DDLS Fellow Luisa Hugerth
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Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis.
Herp S, Brugiroux S, Garzetti D, ..., Berry D, Stecher B
Cell Host Microbe 25 (5) 681-694.e8 [2019-05-08; online 2019-04-18]
Mikael Sellin SciLifeLab Fellow
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Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer.
Turanli B, Karagoz K, Bidkhori G, ..., Mardinoglu A, Arga KY
Front Genet 10 (-) 420 [2019-05-07; online 2019-05-07]
Adil Mardinoglu SciLifeLab Fellow
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Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration.
Li D, Kular L, Vij M, ..., Jagodic M, Landén NX
Proc. Natl. Acad. Sci. U.S.A. 116 (19) 9443-9452 [2019-05-07; online 2019-04-24]
Magda Bienko SciLifeLab Fellow
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Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition.
Liao Q, Lüking M, Krüger DM, ..., Kasson PM, Lynn Kamerlin SC
J Phys Chem B 123 (17) 3576-3590 [2019-05-02; online 2019-04-18]
SciLifeLab Fellow Sebastian Deindl
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Towards the new normal: Transcriptomic convergence and genomic legacy of the two subgenomes of an allopolyploid weed (Capsella bursa-pastoris).
Kryvokhyzha D, Milesi P, Duan T, ..., Glémin S, Lascoux M
PLoS Genet 15 (5) e1008131 [2019-05-00; online 2019-05-13]
Pascal Milesi SciLifeLab Fellow
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Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study.
Skalkidou A, Poromaa IS, Iliadis SI, ..., Freyhult E, Comasco E
Psychoneuroendocrinology 103 (-) 296-305 [2019-05-00; online 2019-02-07]
Erika Comasco SciLifeLab Fellow
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GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology.
Michno W, Wehrli PM, Zetterberg H, Blennow K, Hanrieder J
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Methods Ecol Evol 10 (5) 744-751 [2019-05-00; online 2019-02-24]
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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology.
Michno W, Nyström S, Wehrli P, ..., Zetterberg H, Hanrieder J
J Biol Chem 294 (17) 6719-6732 [2019-04-26; online 2019-02-27]
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Non-Invasive Imaging Methodologies for Assessment of Radiation Damage to Bone Marrow and Kidneys from Peptide Receptor Radionuclide Therapy.
Ahlstedt J, Johansson E, Sydoff M, ..., Gram M, Eriksson O
Neuroendocrinology 110 (1-2) 130-138 [2019-04-19; online 2019-04-19]
Olof Eriksson SciLifeLab Fellow
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Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling.
Sabantsev A, Levendosky RF, Zhuang X, Bowman GD, Deindl S
Nat Commun 10 (1) 1720 [2019-04-12; online 2019-04-12]
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Receptor-Independent Transfer of Low Density Lipoprotein Cargo to Biomembranes.
Axmann M, Sezgin E, Karner A, ..., Stangl H, Plochberger B
Nano Lett. 19 (4) 2562-2567 [2019-04-10; online 2019-03-08]
Erdinc Sezgin SciLifeLab Fellow
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iFISH is a publically available resource enabling versatile DNA FISH to study genome architecture.
Gelali E, Girelli G, Matsumoto M, ..., Crosetto N, Bienko M
Nat Commun 10 (1) 1636 [2019-04-09; online 2019-04-09]
Magda Bienko SciLifeLab Fellow
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System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection.
Garcia-Moreno M, Noerenberg M, Ni S, ..., Mohammed S, Castello A
Mol. Cell 74 (1) 196-211.e11 [2019-04-04; online 2019-02-21]
SciLifeLab Fellow Vicent Pelechano
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Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.
Harms MJ, Li Q, Lee S, ..., Spalding KL, Boucher J
Cell Reports 27 (1) 213-225.e5 [2019-04-02; online 2019-04-04]
Adil Mardinoglu SciLifeLab Fellow
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Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes.
von Herrath M, Pagni PP, Grove K, ..., Karlsen AE, Petersen JS
Cell Metab. 29 (4) 795-802 [2019-04-02; online 2019-03-14]
Gustaf Christoffersson SciLifeLab Fellow
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New Phylogenomic Analysis of the Enigmatic Phylum Telonemia Further Resolves the Eukaryote Tree of Life.
Strassert JFH, Jamy M, Mylnikov AP, Tikhonenkov DV, Burki F
Mol. Biol. Evol. 36 (4) 757-765 [2019-04-01; online 2019-01-23]
Fabien Burki SciLifeLab Fellow
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Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass.
Eriksson J, Roy T, Sawadjoon S, ..., Eriksson O, Odell LR
Nucl. Med. Biol. 71 (-) 1-10 [2019-04-00; online 2019-04-13]
Olof Eriksson SciLifeLab Fellow
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Measuring nanoscale diffusion dynamics in cellular membranes with super-resolution STED-FCS.
Sezgin E, Schneider F, Galiani S, ..., Lagerholm BC, Eggeling C
Nat Protoc 14 (4) 1054-1083 [2019-04-00; online 2019-03-06]
Erdinc Sezgin SciLifeLab Fellow
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Liver macrophages regulate systemic metabolism through non-inflammatory factors.
Morgantini C, Jager J, Li X, ..., Bajgar A, Aouadi M
Nat Metab 1 (4) 445-459 [2019-04-00; online 2019-03-25]
Claudia Kutter SciLifeLab Fellow
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Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning.
Turanli B, Zhang C, Kim W, ..., Arga KY, Mardinoglu A
EBioMedicine 42 (-) 386-396 [2019-04-00; online 2019-03-21]
Adil Mardinoglu SciLifeLab Fellow
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A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.
Ährlund-Richter S, Xuan Y, van Lunteren JA, ..., Meletis K, Carlén M
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Iskra Pollak Dorocic SciLifeLab Fellow
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Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry.
Correia MSP, Ballet C, Meistermann H, Conway LP, Globisch D
Bioorg. Med. Chem. 27 (6) 955-962 [2019-03-15; online 2019-01-30]
Daniel Globisch SciLifeLab Fellow
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Expression of PD-L1 and PD-1 in Chemoradiotherapy-Naïve Esophageal and Gastric Adenocarcinoma: Relationship With Mismatch Repair Status and Survival.
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Front Oncol 9 (-) 136 [2019-03-13; online 2019-03-13]
Adil Mardinoglu SciLifeLab Fellow
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Vertical stratification of bacteria and archaea in sediments of a small boreal humic lake.
Rissanen AJ, Peura S, Mpamah PA, ..., Mäki A, Nykänen H
FEMS Microbiol. Lett. 366 (5) - [2019-03-01; online 2019-02-27]
Sari Peura SciLifeLab Fellow
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Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Liu Z, Zhang C, Lee S, ..., Boren J, Mardinoglu A
Metab. Eng. 52 (-) 263-272 [2019-03-00; online 2019-01-04]
Adil Mardinoglu SciLifeLab Fellow
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Plant microRNAs in human sera are likely contaminants.
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J Nutr Biochem 65 (-) 139-140 [2019-03-00; online 2018-09-05]
Marc Friedländer SciLifeLab Fellow
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Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa.
Monnahan P, Kolář F, Baduel P, ..., Bomblies K, Yant L
Nat Ecol Evol 3 (3) 457-468 [2019-03-00; online 2019-02-25]
SciLifeLab Fellow Tanja Slotte
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Long-term balancing selection drives evolution of immunity genes in Capsella.
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Elife 8 (-) - [2019-02-26; online 2019-02-26]
SciLifeLab Fellow Tanja Slotte
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Evolutionary Implications of the microRNA- and piRNA Complement of Lepidodermella squamata (Gastrotricha).
Fromm B, Tosar JP, Aguilera F, ..., Bachmann L, Hejnol A
Noncoding RNA 5 (1) 19 [2019-02-22; online 2019-02-22]
Marc Friedländer SciLifeLab Fellow
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First-in-class positron emission tomography tracer for the glucagon receptor.
Velikyan I, Haack T, Bossart M, ..., Wagner M, Eriksson O
EJNMMI Res 9 (1) 17 [2019-02-15; online 2019-02-15]
Olof Eriksson SciLifeLab Fellow
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Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass.
Elksnis A, Martinell M, Eriksson O, Espes D
Front. Physiol. 10 (-) 107 [2019-02-13; online 2019-02-13]
Olof Eriksson SciLifeLab Fellow
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A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.
Wright SC, Kozielewicz P, Kowalski-Jahn M, ..., Carlsson J, Schulte G
Nat Commun 10 (1) 667 [2019-02-08; online 2019-02-08]
Jens Carlsson SciLifeLab Fellow
PubMed DOI Crossref
Kinetic modeling of the Calvin cycle identifies flux control and stable metabolomes in Synechocystis carbon fixation.
Janasch M, Asplund-Samuelsson J, Steuer R, Hudson EP
J. Exp. Bot. 70 (3) 973-983 [2019-02-05; online 2018-10-30]
Paul Hudson SciLifeLab Fellow
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Structural Patching Fosters Divergence of Mitochondrial Ribosomes.
Petrov AS, Wood EC, Bernier CR, ..., Brown A, Amunts A
Mol. Biol. Evol. 36 (2) 207-219 [2019-02-01; online 2018-12-06]
Alexey Amunts SciLifeLab Fellow
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Smart scanning for low-illumination and fast RESOLFT nanoscopy in vivo.
Dreier J, Castello M, Coceano G, ..., Vicidomini G, Testa I
Nat Commun 10 (1) 556 [2019-02-01; online 2019-02-01]
Ilaria Testa SciLifeLab Fellow
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Transcription-driven chromatin repression of Intragenic transcription start sites.
Nielsen M, Ard R, Leng X, ..., Pelechano V, Marquardt S
PLoS Genet 15 (2) e1007969 [2019-02-00; online 2019-02-01]
SciLifeLab Fellow Vicent Pelechano
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Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.
Benfeitas R, Bidkhori G, Mukhopadhyay B, ..., Kunos G, Mardinoglu A
EBioMedicine 40 (-) 471-487 [2019-02-00; online 2018-12-31]
Adil Mardinoglu SciLifeLab Fellow
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Discovery of KIRREL as a biomarker for prognostic stratification of patients with thin melanoma.
Lundgren S, Fagerström-Vahman H, Zhang C, ..., Nodin B, Jirström K
Biomark Res 7 (1) 1 [2019-01-14; online 2019-01-14]
Adil Mardinoglu SciLifeLab Fellow
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Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
Guzman-Otazo J, Gonzales-Siles L, Poma V, ..., Iñiguez V, Sjöling Å
PLoS ONE 14 (1) e0210735 [2019-01-14; online 2019-01-14]
DDLS Fellow Johan Bengtsson-Palme
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Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age.
Sundström Poromaa I, Comasco E, Bäckström T, ..., Jensen P, Frokjaer VG
Front Psychol 9 (-) 2767 [2019-01-11; online 2019-01-11]
Erika Comasco SciLifeLab Fellow
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The Circulating Transcriptome as a Source of Biomarkers for Melanoma.
Solé C, Tramonti D, Schramm M, ..., Middleton MR, Lawrie CH
Cancers (Basel) 11 (1) 70 [2019-01-10; online 2019-01-10]
Marc Friedländer SciLifeLab Fellow
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Decreased Snow Cover Stimulates Under-Ice Primary Producers but Impairs Methanotrophic Capacity.
Garcia SL, Szekely AJ, Bergvall C, Schattenhofer M, Peura S
mSphere 4 (1) - [2019-01-09; online 2019-01-09]
Sarahi Garcia Sari Peura SciLifeLab Fellow
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The UNITE database for molecular identification of fungi: handling dark taxa and parallel taxonomic classifications.
Nilsson RH, Larsson KH, Taylor AFS, ..., Kõljalg U, Abarenkov K
Nucleic Acids Res. 47 (D1) D259-D264 [2019-01-08; online 2018-10-30]
DDLS Fellow Johan Bengtsson-Palme
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Ascetosporea.
Bass D, Ward GM, Burki F
Curr. Biol. 29 (1) R7-R8 [2019-01-07; online 2019-01-09]
Fabien Burki SciLifeLab Fellow
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The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium.
Westermann AJ, Venturini E, Sellin ME, ..., Hardt WD, Vogel J
MBio 10 (1) - [2019-01-02; online 2019-01-02]
Mikael Sellin SciLifeLab Fellow
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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System.
de Jong JW, Afjei SA, Pollak Dorocic I, ..., Deisseroth K, Lammel S
Neuron 101 (1) 133-151.e7 [2019-01-02; online 2018-11-29]
Iskra Pollak Dorocic SciLifeLab Fellow
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Large expert-curated database for benchmarking document similarity detection in biomedical literature search.
Brown P, RELISH Consortium , Zhou Y
Database (Oxford) 2019 (-) - [2019-01-01; online 2019-01-01]
DDLS Fellow Johan Bengtsson-Palme
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Allele Phasing Greatly Improves the Phylogenetic Utility of Ultraconserved Elements.
Andermann T, Fernandes AM, Olsson U, ..., Faircloth BC, Antonelli A
Syst. Biol. 68 (1) 32-46 [2019-01-01; online 2018-05-18]
DDLS Fellow Tobias Andermann
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Revisions to the Classification, Nomenclature, and Diversity of Eukaryotes.
Adl SM, Bass D, Lane CE, ..., Zlatogursky V, Zhang Q
J. Eukaryot. Microbiol. 66 (1) 4-119 [2019-01-00; online 2018-09-27]
Fabien Burki SciLifeLab Fellow
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Phylogenomics supports the monophyly of the Cercozoa.
Irwin NAT, Tikhonenkov DV, Hehenberger E, ..., Burki F, Keeling PJ
Mol. Phylogenet. Evol. 130 (-) 416-423 [2019-01-00; online 2018-10-11]
Fabien Burki SciLifeLab Fellow
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Introducing ribosomal tandem repeat barcoding for fungi.
Wurzbacher C, Larsson E, Bengtsson-Palme J, ..., Kagami M, Nilsson RH
Mol Ecol Resour 19 (1) 118-127 [2019-01-00; online 2018-10-24]
DDLS Fellow Johan Bengtsson-Palme
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Nanostructured Minerals and Vitamins for Food Fortification and Food Supplementation
Knijnenburg JTN, Posavec L, Teleki A
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Alexandra Teleki SciLifeLab Fellow
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Assessment and Management of Risks Associated With Antibiotic Resistance in the Environment
Bengtsson-Palme J
Management of Emerging Public Health Issues and Risks: Multidisciplinary Approaches to the Changing Environment - (-) 243-263 [2019-00-00; online 2019-00-00]
DDLS Fellow Johan Bengtsson-Palme
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The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass.
Jahan M, Johnström P, Selvaraju RK, ..., Halldin C, Eriksson O
EJNMMI Res 8 (1) 113 [2018-12-27; online 2018-12-27]
Olof Eriksson SciLifeLab Fellow
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CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity.
Felce JH, Sezgin E, Wane M, ..., Eggeling C, Davis SJ
Sci Signal 11 (561) - [2018-12-18; online 2018-12-18]
Erdinc Sezgin SciLifeLab Fellow
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acI Actinobacteria Assemble a Functional Actinorhodopsin with Natively Synthesized Retinal.
Dwulit-Smith JR, Hamilton JJ, Stevenson DM, ..., McMahon KD, Forest KT
Applied and environmental microbiology 84 (24) - [2018-12-15; online 2018-11-30]
Sarahi Garcia SciLifeLab Fellow
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Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks.
Bonath F, Domingo-Prim J, Tarbier M, Friedländer MR, Visa N
Nucleic Acids Res. 46 (22) 11869-11882 [2018-12-14; online 2018-11-13]
Marc Friedländer SciLifeLab Fellow
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Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.
Bidkhori G, Benfeitas R, Klevstig M, ..., Boren J, Mardinoglu A
Proc. Natl. Acad. Sci. U.S.A. 115 (50) E11874-E11883 [2018-12-11; online 2018-11-27]
Adil Mardinoglu SciLifeLab Fellow
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miRTrace reveals the organismal origins of microRNA sequencing data.
Kang W, Eldfjell Y, Fromm B, ..., Biryukova I, Friedländer MR
Genome Biol. 19 (1) 213 [2018-12-04; online 2018-12-04]
Marc Friedländer SciLifeLab Fellow
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FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.
Wright SC, Cañizal MCA, Benkel T, ..., Schulte G, Hoffmann C
Sci Signal 11 (559) eaar5536 [2018-12-04; online 2018-12-04]
Jens Carlsson SciLifeLab Fellow
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Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus.
Gaviraghi M, Vivori C, Pareja Sanchez Y, ..., Cittaro D, Tonon G
EMBO J. 37 (23) - [2018-12-03; online 2018-10-29]
SciLifeLab Fellow Vicent Pelechano
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Methanogens and Iron-Reducing Bacteria: the Overlooked Members of Mercury-Methylating Microbial Communities in Boreal Lakes.
Bravo AG, Peura S, Buck M, ..., Björn E, Bertilsson S
Applied and environmental microbiology 84 (23) - [2018-12-01; online 2018-11-15]
Sari Peura SciLifeLab Fellow
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Metaxa2 Database Builder: enabling taxonomic identification from metagenomic or metabarcoding data using any genetic marker.
Bengtsson-Palme J, Richardson RT, Meola M, ..., Hartmann M, Nilsson RH
Bioinformatics 34 (23) 4027-4033 [2018-12-01; online 2018-06-19]
DDLS Fellow Johan Bengtsson-Palme
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Multiscale patterns and drivers of arbuscular mycorrhizal fungal communities in the roots and root-associated soil of a wild perennial herb.
Rasmussen PU, Hugerth LW, Blanchet FG, ..., Lindahl BD, Tack AJM
New Phytol. 220 (4) 1248-1261 [2018-12-00; online 2018-03-24]
DDLS Fellow Luisa Hugerth
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HYPERPARAMETER OPTIMIZATION FOR APPROXIMATE BAYESIAN COMPUTATION
Singh P, Hellander A
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Prashant Singh SciLifeLab Fellow
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Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer.
Gotthardt M, Eizirik DL, Aanstoot HJ, ..., Cnop M, Brom M
Diabetologia 61 (12) 2516-2519 [2018-12-00; online 2018-10-03]
Olof Eriksson SciLifeLab Fellow
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Cost-effective generation of precise label-free quantitative proteomes in high-throughput by microLC and data-independent acquisition
Vowinckel J, Zelezniak A, Bruderer R, ..., Reiter L, Ralser M
Sci Rep 8 (1) - [2018-12-00; online 2018-03-12]
Affiliated researcher Aleksej Zelezniak SciLifeLab Fellow
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Control of hepatic gluconeogenesis by Argonaute2.
Yan X, Wang Z, Bishop CA, ..., Willnow TE, Poy MN
Mol Metab 18 (-) 15-24 [2018-12-00; online 2018-10-09]
Marc Friedländer SciLifeLab Fellow
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Bridging gaps in transposable element research with single-molecule and single-cell technologies
Kutter C, Jern P, Suh A
Mobile DNA 9 (1) - [2018-12-00; online 2018-12-06]
Claudia Kutter SciLifeLab Fellow
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RollFISH achieves robust quantification of single-molecule RNA biomarkers in paraffin-embedded tumor tissue samples.
Wu C, Simonetti M, Rossell C, ..., Crosetto N, Nilsson M
Commun Biol 1 (1) 209 [2018-11-28; online 2018-11-28]
Magda Bienko SciLifeLab Fellow
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Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.
Håversen L, Sundelin JP, Mardinoglu A, ..., Levin M, Borén J
Sci Rep 8 (1) 16973 [2018-11-19; online 2018-11-19]
Adil Mardinoglu SciLifeLab Fellow
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Methanomethylophilus alvus Mx1201 Provides Basis for Mutual Orthogonal Pyrrolysyl tRNA/Aminoacyl-tRNA Synthetase Pairs in Mammalian Cells.
Meineke B, Heimgärtner J, Lafranchi L, Elsässer SJ
ACS chemical biology 13 (11) 3087-3096 [2018-11-16; online 2018-10-12]
SciLifeLab Fellow Simon Elsässer
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PREQUAL: detecting non-homologous characters in sets of unaligned homologous sequences.
Whelan S, Irisarri I, Burki F
Bioinformatics 34 (22) 3929-3930 [2018-11-15; online 2018-06-06]
Fabien Burki SciLifeLab Fellow
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Structural Characterization of Agonist Binding to Protease-Activated Receptor 2 through Mutagenesis and Computational Modeling.
Kennedy AJ, Ballante F, Johansson JR, ..., Nordqvist A, Carlsson J
ACS pharmacology & translational science 1 (2) 119-133 [2018-11-09; online 2018-10-16]
Jens Carlsson SciLifeLab Fellow
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A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine.
Turanli B, Karagoz K, Gulfidan G, ..., Mardinoglu A, Arga KY
Curr. Pharm. Des. 24 (32) 3778-3790 [2018-11-07; online 2018-11-07]
Adil Mardinoglu SciLifeLab Fellow
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Forces drive basement membrane invasion in Caenorhabditis elegans.
Cáceres R, Bojanala N, Kelley LC, ..., Sherwood DR, Plastino J
Proc. Natl. Acad. Sci. U.S.A. 115 (45) 11537-11542 [2018-11-06; online 2018-10-22]
Ilaria Testa SciLifeLab Fellow
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Deciphering highly similar multigene family transcripts from Iso-Seq data with IsoCon.
Sahlin K, Tomaszkiewicz M, Makova KD, Medvedev P
Nat Commun 9 (1) 4601 [2018-11-02; online 2018-11-02]
Kristoffer Sahlin SciLifeLab Fellow
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microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function.
Langlet F, Tarbier M, Haeusler RA, ..., Friedländer MR, Accili D
Mol Metab 17 (-) 49-60 [2018-11-00; online 2018-08-11]
Marc Friedländer SciLifeLab Fellow
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Uncovering the regional localization of inhaled salmeterol retention in the lung.
Bäckström E, Hamm G, Nilsson A, ..., Goodwin RJA, Fridén M
Drug Deliv 25 (1) 838-845 [2018-11-00; online 2018-03-29]
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Transfection of crayfish hematopoietic tissue cells.
Shi H, Ruan L, Söderhäll I, Söderhäll K, Xu X
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QCM mass underestimation in molecular biotechnology: Proximity ligation assay for norovirus detection as a case study
Neumann F, Madaboosi N, Hernández-Neuta I, ..., Mecea V, Nilsson M
Sensors and Actuators B: Chemical 273 (-) 742-750 [2018-11-00; online 2018-11-00]
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How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative.
Mobarak E, Javanainen M, Kulig W, ..., Rog T, Vattulainen I
Biochim Biophys Acta Biomembr 1860 (11) 2436-2445 [2018-11-00; online 2018-07-18]
Erdinc Sezgin SciLifeLab Fellow
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Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.
Nilsson KW, Åslund C, Comasco E, Oreland L
J Neural Transm (Vienna) 125 (11) 1601-1626 [2018-11-00; online 2018-06-07]
Erika Comasco SciLifeLab Fellow
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Ribosome Profiling of Synechocystis Reveals Altered Ribosome Allocation at Carbon Starvation
Karlsen J, Asplund-Samuelsson J, Thomas Q, Jahn M, Hudson EP
mSystems 3 (5) - [2018-10-30; online 2018-10-30]
Paul Hudson SciLifeLab Fellow
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Detection of post-translational modifications using solid-phase proximity ligation assay.
Oliveira FMS, Mereiter S, Lönn P, ..., Reis CA, Kamali-Moghaddam M
N Biotechnol 45 (-) 51-59 [2018-10-25; online 2017-10-31]
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Combination of phage and Gram-positive bacterial display of human antibody repertoires enables isolation of functional high affinity binders.
Hu FJ, Volk AL, Persson H, ..., Uhlen M, Rockberg J
N Biotechnol 45 (-) 80-88 [2018-10-25; online 2017-08-01]
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A myopic perspective on the future of protein diagnostics.
Landegren U, Al-Amin RA, Björkesten J
N Biotechnol 45 (-) 14-18 [2018-10-25; online 2018-01-05]
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A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel.
Santner P, Martins JMDS, Laursen JS, ..., Willemoës M, Lindorff-Larsen K
Biochemistry 57 (41) 5949-5956 [2018-10-16; online 2018-10-03]
Lars Behrendt SciLifeLab Fellow
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Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism.
Garg N, Conway LP, Ballet C, ..., Löhr JM, Globisch D
Angew. Chem. Int. Ed. Engl. 57 (42) 13805-13809 [2018-10-15; online 2018-09-20]
Daniel Globisch SciLifeLab Fellow
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Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis.
Shirey RJ, Globisch D, Eubanks LM, Hixon MS, Janda KD
ACS Infect Dis 4 (10) 1423-1431 [2018-10-12; online 2018-09-21]
Daniel Globisch SciLifeLab Fellow
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Quantifying point-mutations in shotgun metagenomic data
Magesh S, Jonsson V, Bengtsson-Palme J
bioRxiv preprint - (-) - [2018-10-11; online 2018-10-11]
DDLS Fellow Johan Bengtsson-Palme
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Growth of Cyanobacteria Is Constrained by the Abundance of Light and Carbon Assimilation Proteins.
Jahn M, Vialas V, Karlsen J, ..., Käll L, Hudson EP
Cell Reports 25 (2) 478-486.e8 [2018-10-09; online 2018-10-12]
Paul Hudson SciLifeLab Fellow
PubMed DOI Crossref
Rapid Isolation of the Mitoribosome from HEK Cells.
Aibara S, Andréll J, Singh V, Amunts A
J Vis Exp - (140) - [2018-10-04; online 2018-10-04]
Alexey Amunts SciLifeLab Fellow
PubMed DOI Crossref
Conceptual and empirical advances in Neotropical biodiversity research.
Antonelli A, Ariza M, Albert J, ..., Zizka A, Edwards SV
PeerJ 6 (-) e5644 [2018-10-04; online 2018-10-04]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Reconstitution of immune cell interactions in free-standing membranes.
Jenkins E, Santos AM, O'Brien-Ball C, ..., Eggeling C, Sezgin E
J. Cell. Sci. 132 (4) - [2018-10-02; online 2018-10-02]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Bacteriophages Synergize with the Gut Microbial Community To Combat Salmonella.
Hu YOO, Hugerth LW, Bengtsson C, ..., Du J, Engstrand L
mSystems 3 (5) - [2018-10-02; online 2018-10-02]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA.
Delemotte L
J. Gen. Physiol. 150 (10) 1356-1359 [2018-10-01; online 2018-08-24]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Determining the molecular basis of voltage sensitivity in membrane proteins.
Kasimova MA, Lindahl E, Delemotte L
J. Gen. Physiol. 150 (10) 1444-1458 [2018-10-01; online 2018-08-27]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome.
Zamani L, Lundqvist M, Zhang Y, ..., Rockberg J, Chotteau V
Biotechnol J 13 (10) e1800036 [2018-10-00; online 2018-07-13]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells.
Maturi V, Enroth S, Heldin CH, Moustakas A
J. Cell. Physiol. 233 (10) 7113-7127 [2018-10-00; online 2018-05-10]
Affiliated researcher
PubMed DOI Crossref
Genomes from uncultivated prokaryotes: a comparison of metagenome-assembled and single-amplified genomes.
Alneberg J, Karlsson CMG, Divne AM, ..., Andersson AF, Pinhassi J
Microbiome 6 (1) 173 [2018-09-28; online 2018-09-28]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling.
Zhang C, Bidkhori G, Benfeitas R, ..., Uhlén M, Mardinoglu A
Front. Physiol. 9 (-) 1355 [2018-09-28; online 2018-09-28]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Bioanalytical advantages of a novel recombinant apyrase enzyme in ATP-based bioluminescence methods.
Pavankumar AR, Zelenin S, Lundin A, ..., Achour A, Russom A
Anal. Chim. Acta 1025 (-) 118-123 [2018-09-26; online 2018-04-26]
Affiliated researcher
PubMed DOI Crossref
Effects of Design Choices on the Stiffness of Wireframe DNA Origami Structures.
Benson E, Mohammed A, Rayneau-Kirkhope D, ..., Orponen P, Högberg B
ACS Nano 12 (9) 9291-9299 [2018-09-25; online 2018-09-06]
Erik Benson SciLifeLab Fellow
PubMed DOI Crossref
Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements.
Pärnänen K, Karkman A, Hultman J, ..., Satokari R, Virta M
Nat Commun 9 (1) 3891 [2018-09-24; online 2018-09-24]
DDLS Fellow Johan Bengtsson-Palme
PubMed DOI Crossref
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.
Lovric A, Granér M, Bjornson E, ..., Mardinoglu A, Boren J
Sci Rep 8 (1) 14200 [2018-09-21; online 2018-09-21]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome.
Liu Z, Liang S, Que S, ..., Zheng S, Mardinoglu A
Front. Physiol. 9 (-) 1238 [2018-09-19; online 2018-09-19]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Phylogeny and Systematics of Kewa (Kewaceae)
Thulin M, Larsson A, Edwards EJ, Moore AJ
Systematic Botany 43 (3) 689-700 [2018-09-10; online 2018-09-10]
Affiliated researcher
PubMed