Studying transcriptional interactions in single cells at sufficient resolution.

Wallden M, Elf J

Curr. Opin. Biotechnol. 22 (1) 81-86 [2011-02-00; online 2010-11-10]

Our ability to dissect and understand the principles of gene regulatory circuits is partly limited by the resolution of our experimental assays. In this brief review, we discuss aspects of gene expression in microbial organisms apparent only when increasing the experimental resolution from populations to single cells and sub-cellular structures, from snap-shots to high-speed time-lapse movies and from molecular ensembles to single molecules.

Affiliated researcher

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PubMed 21071200

DOI 10.1016/j.copbio.2010.10.004

Crossref 10.1016/j.copbio.2010.10.004

S0958-1669(10)00192-8