Sezgin E

Family name	Sezgin
Given name	Erdinc
Initials	E
ORCID	ORCID 0000-0002-4915-388X
Affiliations	Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, 17165 Solna, Sweden MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, U.K.

61 publications

LipiGo: A Versatile DNA-Lipid Nanoparticle Hybrid for Precision Drug Delivery

Kadletz K, Kimna C, Reichenbach VK, ..., Elsner M, Ertürk A

- - (-) - [2025-09-18; online 2025-09-18]

PubMed DOI Crossref

Author Correction: Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.

Sommerauer C, Gallardo-Dodd CJ, Savva C, ..., Williams C, Kutter C

Mol Syst Biol 21 (9) 1282-1283 [2025-09-00; online 2025-06-12]

Lipid-facilitated opening of the ADAM10 sheddase revealed by enhanced sampling simulations

Schahl A, Haloi N, Carroni M, ..., Delemotte L, Howard RJ

- - (-) - [2025-08-22; online 2025-08-22]

Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure

- - (-) - [2025-05-13; online 2025-05-13]

Sheathless elasto-inertial focusing of sub-25 nm particles in straight microchannels

Tanriverdi S, Cruz J, Habibi S, ..., Sezgin E, Russom A

- - (-) - [2025-02-21; online 2025-02-21]

PubMed DOI Crossref

Imaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy.

Sych T, Görgens A, Steiner L, ..., El Andaloussi S, Sezgin E

Nano Lett. 25 (6) 2173-2180 [2025-02-12; online 2025-01-29]

Spectral STED microscopy improves spectral sensitivity with polarity-sensitive probes and enables correlative measurements of membrane order and anomalous lipid diffusion

Urbančič I, Schneider F, Galiani S, Sezgin E, Eggeling C

- - (-) - [2025-02-08; online 2025-02-08]

PubMed DOI Crossref

"Head-to-Toe" Lipid Properties Govern the Binding and Cargo Transfer of High-Density Lipoprotein.

Weber F, Axmann M, Sezgin E, ..., Stangl H, Plochberger B

Membranes (Basel) 14 (12) - [2024-12-06; online 2024-12-06]

PubMed DOI Crossref

Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane.

Oasa S, Sezgin E, Ma Y, ..., Vukojević V, Terenius L

Transl Psychiatry 14 (1) 477 [2024-11-24; online 2024-11-24]

PubMed DOI Crossref

Antibody-displaying extracellular vesicles for targeted cancer therapy.

Wiklander OPB, Mamand DR, Mohammad DK, ..., Görgens A, El Andaloussi S

Nat Biomed Eng 8 (11) 1453-1468 [2024-11-00; online 2024-05-20]

PubMed DOI Crossref

VISION - an open-source software for automated multi-dimensional image analysis of cellular biophysics.

Weber F, Iskrak S, Ragaller F, ..., Sezgin E, Andronico LA

J. Cell. Sci. 137 (20) - [2024-10-15; online 2024-10-23]

PubMed DOI Crossref

Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.

Sommerauer C, Gallardo-Dodd CJ, Savva C, ..., Williams C, Kutter C

Mol Syst Biol 20 (4) 374-402 [2024-04-00; online 2024-03-08]

Claudia Kutter SciLifeLab Fellow

PubMed DOI Crossref

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.

Menon I, Sych T, Son Y, ..., Levitz J, Menon AK

bioRxiv - (-) - [2024-01-05; online 2024-01-05]

PubMed DOI Crossref

Protein-Decorated Microbubbles for Ultrasound-Mediated Cell Surface Manipulation.

Brans VA, Gray MD, Sezgin E, Stride EPJ

ACS Appl Bio Mater 6 (12) 5746-5758 [2023-12-18; online 2023-12-04]

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski B, Christ W, Corman A, ..., Huhn D, Fernandez-Capetillo O

- - (-) - [2023-10-26; online 2023-10-26]

Estrogen receptor activation remodelsTEAD1gene expression to alleviate nonalcoholic fatty liver disease

Sommerauer C, Gallardo-Dodd CJ, Savva C, ..., Williams C, Kutter C

- - (-) - [2023-09-08; online 2023-09-08]

Claudia Kutter SciLifeLab Fellow

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

Drexhage LZ, Zhang S, DuPont M, ..., Karaji N, Sattentau QJ

- - (-) - [2023-08-23; online 2023-08-23]

Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry

Doktorova M, Symons JL, Zhang X, ..., Levental KR, Levental I

- - (-) - [2023-07-31; online 2023-07-31]

DDLS Fellow Milka Doktorova

PubMed DOI Crossref

Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane.

Terenius L, Oasa S, Sezgin E, ..., Martin-Fardon R, Vukojevic V

Res Sq - (-) - [2023-07-21; online 2023-07-21]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells.

Sternstein C, Böhm TM, Fink J, ..., Ebert R, Seibel J

Bioconjug. Chem. 34 (7) 1221-1233 [2023-07-19; online 2023-06-16]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler.

Sych T, Schlegel J, Barriga HMG, ..., Stevens MM, Sezgin E

Nat. Biotechnol. - (-) - [2023-06-12; online 2023-06-12]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens.

Schlegel J, Porebski B, Andronico L, ..., Fernandez-Capetillo O, Sezgin E

Nano Lett. 23 (9) 3701-3707 [2023-05-10; online 2023-03-09]

PubMed DOI Crossref

Voices of the new generation: normalizing career choices outside academia.

Nat. Rev. Mol. Cell Biol. 24 (4) 237 [2023-04-00; online 2023-01-20]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.

Cikes D, Elsayad K, Sezgin E, ..., Banka S, Penninger JM

Nat Metab 5 (4) 711 [2023-04-00; online 2023-04-07]

PubMed DOI Crossref

Do lipids tune B cell signaling?

Urbančič I, Eggeling C, Sezgin E

Nat. Chem. Biol. - (-) - [2023-03-30; online 2023-03-30]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.

Cikes D, Elsayad K, Sezgin E, ..., Banka S, Penninger JM

Nat Metab 5 (3) 495-515 [2023-03-00; online 2023-03-20]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Influence of the extracellular domain size on the dynamic behavior of membrane proteins.

Gurdap CO, Wedemann L, Sych T, Sezgin E

Biophys. J. 121 (20) 3826-3836 [2022-10-18; online 2022-09-14]

Erdinc Sezgin SciLifeLab Fellow

A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens

Schlegel J, Porebski B, Andronico L, ..., Fernandez-Capetillo O, Sezgin E

- - (-) - [2022-10-11; online 2022-10-11]

PubMed DOI Crossref

Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties.

Ragaller F, Andronico L, Sykora J, ..., Vattulainen I, Sezgin E

Open Biol 12 (9) 220175 [2022-09-00; online 2022-09-14]

Erdinc Sezgin SciLifeLab Fellow

Single particle profiler for measuring content and properties of nano-sized bioparticles

Sych T, Schlegel J, Barriga HMG, ..., Stevens MM, Sezgin E

- - (-) - [2022-07-10; online 2022-07-10]

PubMed DOI Crossref

T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.

Céspedes PF, Jainarayanan A, Fernández-Messina L, ..., Sánchez-Madrid F, Dustin ML

Nat Commun 13 (1) 3460 [2022-06-16; online 2022-06-16]

Erdinc Sezgin SciLifeLab Fellow

Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties

Ragaller F, Andronico L, Sykora J, ..., Vattulainen I, Sezgin E

- - (-) - [2022-06-05; online 2022-06-05]

PubMed DOI Crossref

Understanding immune signaling using advanced imaging techniques.

Brameshuber M, Klotzsch E, Ponjavic A, Sezgin E

Biochem. Soc. Trans. 50 (2) 853-866 [2022-04-29; online 2022-03-29]

Erdinc Sezgin SciLifeLab Fellow

Critical role of PCYT2 in muscle health and aging

Cikes D, Elsayad K, Sezgin E, ..., Banka S, Penninger JM

- - (-) - [2022-03-03; online 2022-03-03]

PubMed DOI Crossref

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.

Hanke L, Das H, Sheward DJ, ..., Murrell B, McInerney GM

Nat Commun 13 (1) 155 [2022-01-10; online 2022-01-10]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Long-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes.

Carravilla P, Dasgupta A, Zhurgenbayeva G, ..., Sezgin E, Eggeling C

Biophys Rep (N Y) 1 (2) None [2021-12-08; online 2021-12-08]

Erdinc Sezgin SciLifeLab Fellow

Influence of the extracellular domain size on the dynamic behavior of membrane proteins

Gurdap CO, Wedemann L, Sych T, Sezgin E

- - (-) - [2021-11-16; online 2021-11-16]

PubMed DOI Crossref

Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells.

Urbančič I, Schiffelers L, Jenkins E, ..., Sezgin E, Eggeling C

FEBS Lett. 595 (16) 2127-2146 [2021-08-00; online 2021-07-07]

Erdinc Sezgin SciLifeLab Fellow

STED super-resolution imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes

Carravilla P, Dasgupta A, Zhurgenbayeva G, ..., Sezgin E, Eggeling C

- - (-) - [2021-06-05; online 2021-06-05]

PubMed DOI Crossref

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.

Oftedal BE, Maio S, Handel AE, ..., Maizels RM, Holländer GA

Commun Biol 4 (1) 681 [2021-06-03; online 2021-06-03]

Erdinc Sezgin SciLifeLab Fellow

Synthetic antigen-presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses

Céspedes PF, Jainarayanan A, Fernández-Messina L, ..., Sánchez-Madrid F, Dustin ML

- - (-) - [2021-05-29; online 2021-05-29]

Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5

Galiani S, Reglinski K, Carravilla P, ..., Erdmann R, Eggeling C

- - (-) - [2021-05-26; online 2021-05-26]

PubMed DOI Crossref

How Does Liquid-Liquid Phase Separation in Model Membranes Reflect Cell Membrane Heterogeneity?

Sych T, Gurdap CO, Wedemann L, Sezgin E

Membranes (Basel) 11 (5) - [2021-04-28; online 2021-04-28]

Erdinc Sezgin SciLifeLab Fellow

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency

Rota IA, Handel AE, Klein F, ..., Sezgin E, Holländer GA

- - (-) - [2021-03-29; online 2021-03-29]

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

Hanke L, Das H, Sheward DJ, ..., Murrell B, McInerney GM

- - (-) - [2021-03-21; online 2021-03-21]

PubMed DOI Crossref

Model membrane systems to reconstitute immune cell signaling.

Céspedes PF, Beckers D, Dustin ML, Sezgin E

FEBS J. 288 (4) 1070-1090 [2021-02-00; online 2020-08-03]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis.

Ozalp O, Cark O, Azbazdar Y, ..., Sezgin E, Ozhan G

Biomolecules 11 (1) - [2021-01-14; online 2021-01-14]

Erdinc Sezgin SciLifeLab Fellow

Aggregation and immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells

Urbančič I, Schiffelers L, Jenkins E, ..., Sezgin E, Eggeling C

- - (-) - [2020-12-22; online 2020-12-22]

PubMed DOI Crossref

Lipoprotein Particles Interact with Membranes and Transfer Their Cargo without Receptors

Plochberger B, Sych T, Weber F, ..., Stangl H, Sezgin E

Biochemistry 59 (45) 4421-4428 [2020-11-17; online 2020-11-04]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes.

Danylchuk DI, Sezgin E, Chabert P, Klymchenko AS

Anal. Chem. 92 (21) 14798-14805 [2020-11-03; online 2020-10-12]

Erdinc Sezgin SciLifeLab Fellow

Lipoprotein particles interact with membranes and transfer their cargo without receptors

Plochberger B, Sych T, Weber F, ..., Stangl H, Sezgin E

- - (-) - [2020-08-28; online 2020-08-28]

PubMed DOI Crossref

Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad.

Frawley AT, Wycisk V, Xiong Y, ..., Eggeling C, Anderson HL

Chem Sci 11 (33) 8955-8960 [2020-08-10; online 2020-08-10]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation.

Sieben C, Sezgin E, Eggeling C, Manley S

PLoS Pathog 16 (7) e1008656 [2020-07-00; online 2020-07-08]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape.

Lorent JH, Levental KR, Ganesan L, ..., Lyman E, Levental I

Nat. Chem. Biol. 16 (6) 644-652 [2020-06-00; online 2020-05-04]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Author Correction: Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape.

Lorent JH, Levental KR, Ganesan L, ..., Lyman E, Levental I

Nat. Chem. Biol. 16 (6) 710 [2020-06-00; online 2020-05-18]

PubMed DOI Crossref

z-STED Imaging and Spectroscopy to Investigate Nanoscale Membrane Structure and Dynamics.

Barbotin A, Urbančič I, Galiani S, ..., Booth M, Sezgin E

Biophys. J. 118 (10) 2448-2457 [2020-05-19; online 2020-04-16]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy.

Schneider F, Hernandez-Varas P, Christoffer Lagerholm B, ..., Eggeling C, Urbančič I

J. Phys. D: Appl. Phys. 53 (16) 164003 [2020-04-15; online 2020-02-13]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Impact of Nanoscale Hindrances on the Relationship between Lipid Packing and Diffusion in Model Membranes.

Beckers D, Urbancic D, Sezgin E

J Phys Chem B 124 (8) 1487-1494 [2020-02-27; online 2020-02-18]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Creating Supported Plasma Membrane Bilayers Using Acoustic Pressure.

Sezgin E, Carugo D, Levental I, Stride E, Eggeling C

Membranes (Basel) 10 (2) 30 [2020-02-18; online 2020-02-18]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Regulation of lipid saturation without sensing membrane fluidity.

Ballweg S, Sezgin E, Doktorova M, ..., Hummer G, Ernst R

Nat Commun 11 (1) 756 [2020-02-06; online 2020-02-06]

DDLS Fellow Erdinc Sezgin Milka Doktorova SciLifeLab Fellow

z-STED imaging and spectroscopy to investigate nanoscale membrane structure and dynamics

Barbotin A, Urbančič I, Galiani S, ..., Booth M, Sezgin E

- - (-) - [2019-12-28; online 2019-12-28]

SciLifeLab Data Centre

Publications 9.5.1