Vicent Pelechano

Rpb4 and Puf3 imprint and post-transcriptionally control the stability of a common set of mRNAs in yeast.

Garrido-Godino AI, Gupta I, Gutiérrez-Santiago F, ..., Pelechano V, Navarro F

RNA Biol 18 (8) 1206-1220 [2021-08-00; online 2020-11-01]

Year 2020

Improved computational analysis of ribosome dynamics from 5′P degradome data using fivepseq

Nersisyan L, Ropat M, Pelechano V

NAR Genomics and Bioinformatics 2 (4) - [2020-11-24; online 2020-11-24]

TIF-Seq2 disentangles overlapping isoforms in complex human transcriptomes.

Wang J, Li B, Marques S, ..., Wei W, Pelechano V

Nucleic Acids Res. 48 (18) e104 [2020-10-09; online 2020-08-21]

The RNA exosome shapes the expression of key protein-coding genes.

Wu M, Karadoulama E, Lloret-Llinares M, ..., Jensen TH, Sandelin A

Nucleic Acids Res. 48 (15) 8509-8528 [2020-09-04; online 2020-07-28]

Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape.

Liang S, Ezerskyte M, Wang J, Pelechano V, Dreij K

Sci Rep 10 (1) 13513 [2020-08-11; online 2020-08-11]

Rapid Detection of COVID-19 Coronavirus Using a Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) Diagnostic Platform.

Yu L, Wu S, Hao X, ..., Chen WH, Yin X

Clin. Chem. 66 (7) 975-977 [2020-07-01; online 2020-04-22]

Transcript isoform sequencing reveals widespread promoter-proximal transcriptional termination in Arabidopsis.

Thomas QA, Ard R, Liu J, ..., Pelechano V, Marquardt S

Nat Commun 11 (1) 2589 [2020-05-22; online 2020-05-22]

Year 2019

Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast.

Wei W, Hennig BP, Wang J, ..., Steinmetz LM, Pelechano V

Genome Res 29 (12) 1974-1984 [2019-12-00; online 2019-11-18]

System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection.

Garcia-Moreno M, Noerenberg M, Ni S, ..., Mohammed S, Castello A

Mol. Cell 74 (1) 196-211.e11 [2019-04-04; online 2019-02-21]

Transcription-driven chromatin repression of Intragenic transcription start sites.

Nielsen M, Ard R, Leng X, ..., Pelechano V, Marquardt S

PLoS Genet 15 (2) e1007969 [2019-02-00; online 2019-02-01]

Year 2018

Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus.

Gaviraghi M, Vivori C, Pareja Sanchez Y, ..., Cittaro D, Tonon G

EMBO J. 37 (23) - [2018-12-03; online 2018-10-29]

The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock.

Garre E, Pelechano V, Sánchez Del Pino M, Alepuz P, Sunnerhagen P

PLoS Genet 14 (7) e1007563 [2018-07-00; online 2018-07-30]

Affiliated researcher Fellows programme Vicent Pelechano

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S

Nat Commun 9 (1) 2071 [2018-05-22; online 2018-05-22]

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S

Nat Commun 9 (1) 1107 [2018-03-16; online 2018-03-16]

Affiliated researcher Fellows programme Vicent Pelechano

Year 2017

From transcriptional complexity to cellular phenotypes: Lessons from yeast.

Pelechano V

Yeast 34 (12) 475-482 [2017-12-00; online 2017-10-11]

Affiliated researcher Fellows programme Vicent Pelechano

Multiplexed ChIP-Seq Using Direct Nucleosome Barcoding: A Tool for High-Throughput Chromatin Analysis.

Chabbert CD, Adjalley SH, Steinmetz LM, Pelechano V

Methods in molecular biology (Clifton, N.J.) 1689 (-) 177-194 [2017-10-14; online 2017-10-14]

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.

Gómez-Herreros F, Margaritis T, Rodríguez-Galán O, ..., Holstege FCP, Chávez S

Nucleic Acids Res. 45 (16) 9302-9318 [2017-09-19; online 2017-06-24]

Affiliated researcher Fellows programme Vicent Pelechano

eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences.

Pelechano V, Alepuz P

Nucleic Acids Res. 45 (12) 7326-7338 [2017-07-07; online 2017-05-27]

Affiliated researcher Fellows programme Vicent Pelechano

DOI Crossref

Long Non Coding RNA Biology

Springer [book] (-) - [2017-00-00; online 2017-00-00]

Year 2016

A global genetic interaction network maps a wiring diagram of cellular function.

Costanzo M, VanderSluis B, Koch EN, ..., Andrews B, Boone C

Science (New York, N.Y.) 353 (6306) aaf1420-aaf1420 [2016-09-23; online 2016-10-07]

Affiliated researcher Fellows programme Vicent Pelechano

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters.

Chen Y, Pai AA, Herudek J, ..., Jensen TH, Sandelin A

Nat. Genet. 48 (9) 984-994 [2016-09-00; online 2016-07-25]

Affiliated researcher Fellows programme Vicent Pelechano

Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

Chlamydas S, Holz H, Samata M, ..., Steinmetz LM, Akhtar A

Nat. Struct. Mol. Biol. 23 (6) 580-589 [2016-06-00; online 2016-05-16]

Affiliated researcher Fellows programme Vicent Pelechano

The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons.

García-Martínez J, Delgado-Ramos L, Ayala G, ..., Chávez S, Pérez-Ortín JE

Nucleic Acids Res. 44 (8) 3643-3658 [2016-05-05; online 2015-12-29]

Rpb1 foot mutations demonstrate a major role of Rpb4 in mRNA stability during stress situations in yeast.

Garrido-Godino AI, García-López MC, García-Martínez J, ..., Pérez-Ortín JE, Navarro F

Biochim. Biophys. Acta 1859 (5) 731-743 [2016-05-00; online 2016-03-18]

Affiliated researcher Fellows programme Vicent Pelechano

Landscape and Dynamics of Transcription Initiation in the Malaria Parasite Plasmodium falciparum.

Adjalley SH, Chabbert CD, Klaus B, Pelechano V, Steinmetz LM

Cell Reports 14 (10) 2463-2475 [2016-03-15; online 2016-03-03]

Affiliated researcher Fellows programme Vicent Pelechano

Genome-wide quantification of 5'-phosphorylated mRNA degradation intermediates for analysis of ribosome dynamics.

Pelechano V, Wei W, Steinmetz LM

Nat Protoc 11 (2) 359-376 [2016-02-00; online 2016-01-28]

Year 2015

Biotin-Genomic Run-On (Bio-GRO): A High-Resolution Method for the Analysis of Nascent Transcription in Yeast.

Jordán-Pla A, Miguel A, Serna E, Pelechano V, Pérez-Ortín JE

Methods in molecular biology (Clifton, N.J.) 1361 (-) 125-139 [2015-10-21; online 2015-10-21]

Genome-Wide Identification of Alternative Polyadenylation Events Using 3'T-Fill.

Wilkening S, Pelechano V, Steinmetz LM

Methods in molecular biology (Clifton, N.J.) 1358 (-) 295-302 [2015-10-16; online 2015-10-16]

The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production

Schmid M, Olszewski P, Pelechano V, ..., Steinmetz LM, Jensen TH

Cell Reports 12 (1) 128-139 [2015-07-00; online 2015-07-00]

Single-cell polyadenylation site mapping reveals 3' isoform choice variability.

Velten L, Anders S, Pekowska A, ..., Pelechano V, Steinmetz LM

Mol Syst Biol 11 (6) 812 [2015-06-03; online 2015-06-03]

Widespread Co-translational RNA Decay Reveals Ribosome Dynamics

Pelechano V, Wei W, Steinmetz LM

Cell 161 (6) 1400-1412 [2015-06-00; online 2015-06-00]

Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle

Jordán-Pla A, Gupta I, de Miguel-Jiménez L, ..., Pelechano V, Pérez-Ortín JE

Nucleic Acids Res. 43 (2) 787-802 [2015-01-30; online 2014-12-29]

A high-throughput ChIP-Seq for large-scale chromatin studies.

Chabbert CD, Adjalley SH, Klaus B, ..., Pelechano V, Steinmetz LM

Mol Syst Biol 11 (1) 777 [2015-01-12; online 2015-01-12]

Year 2014

Genome-wide identification of transcript start and end sites by transcript isoform sequencing

Pelechano V, Wei W, Jakob P, Steinmetz LM

Nat Protoc 9 (7) 1740-1759 [2014-07-00; online 2014-06-26]

Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits

Piazza I, Rutkowska A, Ori A, ..., Beck M, Haering CH

Nat Struct Mol Biol 21 (6) 560-568 [2014-06-00; online 2014-05-18]

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions

Gupta I, Clauder-Munster S, Klaus B, ..., Pelechano V, Steinmetz LM

Mol Syst Biol 10 (2) 719-719 [2014-03-20; online 2014-02-25]

Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae

Magraner-Pardo L, Pelechano V, Coloma M, Tordera V

BMC Genomics 15 (1) 247 [2014-00-00; online 2014-00-00]

Year 2013

Gene regulation by antisense transcription

Pelechano V, Steinmetz LM

Nat Rev Genet 14 (12) 880-893 [2013-12-00; online 2013-11-12]

Polyadenylation site–induced decay of upstream transcripts enforces promoter directionality

Ntini E, Järvelin AI, Bornholdt J, ..., Sandelin A, Jensen TH

Nat Struct Mol Biol 20 (8) 923-928 [2013-08-00; online 2013-07-14]

Extensive transcriptional heterogeneity revealed by isoform profiling

Pelechano V, Wei W, Steinmetz LM

Nature 497 (7447) 127-131 [2013-04-24; online 2013-04-24]

An efficient method for genome-wide polyadenylation site mapping and RNA quantification

Wilkening S, Pelechano V, Järvelin AI, ..., Benes V, Steinmetz LM

Nucleic Acids Res. 41 (5) e65-e65 [2013-03-01; online 2013-01-07]

Year 2012

Genome-wide polyadenylation site mapping.

Pelechano V, Wilkening S, Järvelin AI, Tekkedil MM, Steinmetz LM

Meth. Enzymol. 513 (-) 271-296 [2012-08-30; online 2012-08-30]

Rrp6p Controls mRNA Poly(A) Tail Length and Its Decoration with Poly(A) Binding Proteins

Schmid M, Poulsen MB, Olszewski P, ..., Moore C, Jensen TH

Molecular Cell 47 (2) 267-280 [2012-07-00; online 2012-07-00]

The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast.

García-Martínez J, Ayala G, Pelechano V, ..., Herrero E, Pérez-Ortín JE

Transcription 3 (1) 39-44 [2012-03-30; online 2012-03-30]

Year 2011

The Conserved Foot Domain of RNA Pol II Associates with Proteins Involved in Transcriptional Initiation and/or Early Elongation

García-López MC, Pelechano V, Mirón-García MC, ..., Pérez-Ortín JE, Navarro F

Genetics 189 (4) 1235-1248 [2011-12-00; online 2011-09-27]

A genomic view of mRNA turnover in yeast

Pérez-Ortín JE, Jordán-Pla A, Pelechano V

Comptes Rendus Biologies 334 (8-9) 647-654 [2011-08-00; online 2011-08-00]

Functional consequences of bidirectional promoters

Wei W, Pelechano V, Järvelin AI, Steinmetz LM

Trends in Genetics 27 (7) 267-276 [2011-07-00; online 2011-07-00]

Genomic-wide methods to evaluate transcription rates in yeast.

García-Martínez J, Pelechano V, Pérez-Ortín JE

Methods in molecular biology (Clifton, N.J.) 734 (-) 25-44 [2011-04-07; online 2011-04-07]

Year 2010

A Complete Set of Nascent Transcription Rates for Yeast Genes

Pelechano V, Chávez S, Pérez-Ortín JE

PLoS ONE 5 (11) e15442 [2010-11-16; online 2010-11-16]

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors

Rodríguez-Gil A, García-Martínez J, Pelechano V, ..., Pérez-Ortín JE, Chávez S

Nucleic Acids Res. 38 (14) 4651-4664 [2010-08-00; online 2010-04-10]

There is a steady-state transcriptome in exponentially growing yeast cells

Pelechano V, Pérez-Ortín JE

Yeast 27 (7) 413-422 [2010-03-17; online 2010-03-17]

Year 2009

Regulon-specific control of transcription elongation across the yeast genome.

Pelechano V, Jimeno-González S, Rodríguez-Gil A, ..., Pérez-Ortín JE, Chávez S

PLoS Genet 5 (8) e1000614 [2009-08-00; online 2009-08-21]

Year 2008

The transcriptional inhibitor thiolutin blocks mRNA degradation in yeast.

Pelechano V, Pérez-Ortín JE

Yeast 25 (2) 85-92 [2008-02-00; online 2007-10-05]

Year 2006