Synthetic approaches to radiochemical probes for imaging of bacterial infections.

Dutta J, Naicker T, Ebenhan T, Kruger HG, Arvidsson PI, Govender T

Eur J Med Chem 133 (-) 287-308 [2017-06-16; online 2017-03-29]

This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes for tomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions/procedures for the preparation of the probes.

Affiliated researcher

PubMed 28395216

DOI 10.1016/j.ejmech.2017.03.060

Crossref 10.1016/j.ejmech.2017.03.060

pii: S0223-5234(17)30227-1

Publications 9.5.0