J Biol Chem

ISSN	1083-351X
ISSN-L	0021-9258
IUID	0e8a744200684b45bc2a89a1cdeafde3
Modified	2020-11-27T13:12:52.256Z
Created	2020-11-05T16:19:24.769Z

Year 2024

PubMed DOI Crossref

Aberrant overexpression of myosin 1b in glioblastoma promotes angiogenesis via VEGF-myc-myosin 1b-Piezo1 axis.

Lv W, Yang F, Ge Z, ..., Jiang X, Zhang Y

J Biol Chem 300 (11) 107807 [2024-11-00; online 2024-09-20]

PubMed DOI Crossref

Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling.

Voytyuk O, Ohata Y, Moustakas A, Ten Dijke P, Heldin CH

J Biol Chem 300 (7) 107462 [2024-07-00; online 2024-06-12]

PubMed DOI Crossref

A peptidoglycan N-deacetylase specific for anhydroMurNAc chain termini in Agrobacterium tumefaciens.

Gilmore MC, Yadav AK, Espaillat A, ..., Brown PJB, Cava F

J Biol Chem 300 (2) 105611 [2024-02-00; online 2023-12-28]

Year 2023

PubMed DOI Crossref

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.

Kotliar IB, Ceraudo E, Kemelmakher-Liben K, ..., Schwenk JM, Sakmar TP

J Biol Chem 299 (5) 104664 [2023-05-00; online 2023-03-30]

PubMed DOI Crossref

Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells.

Hsu J, Fatuzzo N, Weng N, ..., Nasca C, Khosla C

J Biol Chem 299 (2) 102848 [2023-02-00; online 2022-12-30]

SciLifeLab Fellow Wojciech Michno

Year 2022

PubMed DOI Crossref

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease.

Taylor G, Frommherz Y, Katikaridis P, ..., Weber-Ban E, Mogk A

J Biol Chem 298 (8) 102202 [2022-08-00; online 2022-06-26]

PubMed DOI Crossref

Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.

Jemth AS, Scaletti ER, Homan E, ..., Helleday T, Michel M

J Biol Chem 298 (8) 102169 [2022-08-00; online 2022-06-19]

PubMed DOI Crossref

ADAR1- and ADAR2-mediated regulation of maturation and targeting of miR-376b to modulate GABA neurotransmitter catabolism.

Widmark A, Sagredo EA, Karlström V, ..., Daniel C, Öhman M

J Biol Chem 298 (3) 101682 [2022-03-00; online 2022-02-03]

Marc Friedländer SciLifeLab Fellow

Year 2021

PubMed DOI Crossref

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site.

Sridhar A, Lummis SCR, Pasini D, ..., Howard RJ, Ulens C

J Biol Chem 297 (2) 100899 [2021-08-00; online 2021-06-19]

PubMed DOI Crossref

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.

Rehling D, Zhang SM, Jemth AS, ..., Helleday T, Stenmark P

J Biol Chem 296 (-) 100568 [2021-03-19; online 2021-03-19]

Year 2020

PubMed DOI Crossref

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.

Ladds MJGW, Popova G, Pastor-Fernández A, ..., Lane DP, Laín S

J Biol Chem 295 (52) 17935-17949 [2020-12-25; online 2020-09-08]

PubMed DOI Crossref

Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation.

Burchfiel ET, Vihervaara A, Guertin MJ, Gomez-Pastor R, Thiele DJ

J Biol Chem 296 (-) 100097 [2020-11-24; online 2020-11-24]

Anniina Vihervaara SciLifeLab Fellow

PubMed DOI Crossref

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.

Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P

J Biol Chem 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]

PubMed DOI Crossref

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS

J Biol Chem 295 (15) 4761-4772 [2020-04-10; online 2020-03-06]

Year 2019

PubMed DOI Crossref

Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins.

Kutin Y, Kositzki R, Branca RMM, ..., Cox N, Griese JJ

J Biol Chem 294 (48) 18372-18386 [2019-11-29; online 2019-10-07]

PubMed DOI Crossref

Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly.

Ndi M, Masuyer G, Dawitz H, ..., Stenmark P, Ott M

J Biol Chem 294 (45) 16663-16671 [2019-11-08; online 2019-09-19]

PubMed DOI Crossref

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology.

Michno W, Nyström S, Wehrli P, ..., Zetterberg H, Hanrieder J

J Biol Chem 294 (17) 6719-6732 [2019-04-26; online 2019-02-27]

SciLifeLab Fellow Wojciech Michno

PubMed DOI Crossref

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.

Kolliopoulos C, Raja E, Razmara M, ..., Moustakas A, van der Heide LP

J Biol Chem 294 (11) 4119-4136 [2019-03-15; online 2019-01-08]

PubMed DOI Crossref

Transglutaminase inhibition stimulates hematopoiesis and reduces aggressive behavior of crayfish, Pacifastacus leniusculus.

Junkunlo K, Söderhäll K, Söderhäll I

J Biol Chem 294 (2) 708-715 [2019-01-11; online 2018-11-13]

Year 2018

PubMed DOI Crossref

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.

Strakova K, Kowalski-Jahn M, Gybel T, ..., Bryja V, Schulte G

J Biol Chem 293 (48) 18477-18493 [2018-11-30; online 2018-10-11]

PubMed DOI Crossref

Membrane protein serendipity.

von Heijne G

J Biol Chem 293 (10) 3470-3476 [2018-03-09; online 2018-03-11]

Year 2017

PubMed DOI Crossref

Molecular simulations and free-energy calculations suggest conformation-dependent anion binding to a cytoplasmic site as a mechanism for Na+/K+-ATPase ion selectivity.

Razavi AM, Delemotte L, Berlin JR, Carnevale V, Voelz VA

J Biol Chem 292 (30) 12412-12423 [2017-07-28; online 2017-06-06]

Year 2016

PubMed DOI Crossref

The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.

Rorsman C, Tsioumpekou M, Heldin CH, Lennartsson J

J Biol Chem 291 (22) 11608-11618 [2016-05-27; online 2016-04-05]

Year 2015

PubMed DOI Crossref

Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor.

Griese JJ, Kositzki R, Schrapers P, ..., Haumann M, Högbom M

J Biol Chem 290 (42) 25254-25272 [2015-10-16; online 2015-08-31]

PubMed DOI Crossref

miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism.

Tattikota SG, Rathjen T, Hausser J, ..., Friedländer MR, Poy MN

J Biol Chem 290 (33) 20284-20294 [2015-08-14; online 2015-07-07]

PubMed DOI Crossref

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response.

O'Callaghan P, Li JP, Lannfelt L, Lindahl U, Zhang X

J Biol Chem 290 (24) 14904-14914 [2015-06-12; online 2015-04-13]

PubMed DOI Crossref

Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.

Cymer F, Hedman R, Ismail N, von Heijne G

J Biol Chem 290 (16) 10208-10215 [2015-04-17; online 2015-02-24]

PubMed DOI Crossref

Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine.

Stäubert C, Bhuiyan H, Lindahl A, ..., Lehtiö J, Nordström A

J Biol Chem 290 (13) 8348-8359 [2015-03-27; online 2015-02-19]

PubMed DOI Crossref

Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor protein transgenic mice.

Jendresen CB, Cui H, Zhang X, ..., Nilsson LNG, Li JP

J Biol Chem 290 (8) 5053-5064 [2015-02-20; online 2014-12-29]

Year 2014

PubMed DOI Crossref

The Eph tyrosine kinase receptors EphB2 and EphA2 are novel proteolytic substrates of tissue factor/coagulation factor VIIa.

Eriksson O, Ramström M, Hörnaeus K, ..., Mokhtari D, Siegbahn A

J Biol Chem 289 (47) 32379-32391 [2014-11-21; online 2014-10-03]

PubMed DOI Crossref

Platelet-derived growth factor β-receptor, transforming growth factor β type I receptor, and CD44 protein modulate each other's signaling and stability.

Porsch H, Mehić M, Olofsson B, Heldin P, Heldin CH

J Biol Chem 289 (28) 19747-19757 [2014-07-11; online 2014-05-23]

PubMed DOI Crossref

Increased C-telopeptide cross-linking of tendon type I collagen in fibromodulin-deficient mice.

Kalamajski S, Liu C, Tillgren V, ..., Weis M, Eyre DR

J Biol Chem 289 (27) 18873-18879 [2014-07-04; online 2014-05-21]

Year 2013

PubMed DOI Crossref

Bile acids modulate signaling by functional perturbation of plasma membrane domains.

Zhou Y, Maxwell KN, Sezgin E, ..., Lichtenberger LM, Levental I

J Biol Chem 288 (50) 35660-35670 [2013-12-13; online 2013-10-28]

Erdinc Sezgin SciLifeLab Fellow

PubMed DOI Crossref

Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death.

Linderoth E, Pilia G, Mahajan NP, Ferby I

J Biol Chem 288 (46) 32922-32931 [2013-11-15; online 2013-10-01]

PubMed DOI Crossref

Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.

Lu J, Vodnala SK, Gustavsson AL, ..., Rottenberg ME, Holmgren A

J Biol Chem 288 (38) 27456-27468 [2013-09-20; online 2013-07-29]

PubMed DOI Crossref

MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA).

Kasza Z, Fredlund Fuchs P, Tamm C, ..., Kjellén L, Kreuger J

J Biol Chem 288 (36) 25956-25963 [2013-09-06; online 2013-07-24]

PubMed DOI Crossref

The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo.

Lennartsson J, Ma H, Wardega P, ..., Hellberg C, Heldin CH

J Biol Chem 288 (22) 15736-15744 [2013-05-31; online 2013-04-15]

PubMed DOI Crossref

Dislocation by the m-AAA protease increases the threshold hydrophobicity for retention of transmembrane helices in the inner membrane of yeast mitochondria.

Botelho SC, Tatsuta T, von Heijne G, Kim H

J Biol Chem 288 (7) 4792-4798 [2013-02-15; online 2013-01-02]

PubMed DOI Crossref

A specific and essential role for Na,K-ATPase α3 in neurons co-expressing α1 and α3.

Azarias G, Kruusmägi M, Connor S, ..., Broberger C, Aperia A

J Biol Chem 288 (4) 2734-2743 [2013-01-25; online 2012-11-29]

Year 2012

PubMed DOI Crossref

Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.

Neumayer G, Helfricht A, Shim SY, ..., Helleday T, Nguyen MD

J Biol Chem 287 (50) 42206-42222 [2012-12-07; online 2012-10-08]

PubMed DOI Crossref

Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.

Jeppsson F, Eketjäll S, Janson J, ..., Bueters T, Fälting J

J Biol Chem 287 (49) 41245-41257 [2012-11-30; online 2012-10-09]

PubMed DOI Crossref

On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis.

Holmborn K, Habicher J, Kasza Z, ..., Kreuger J, Ledin J

J Biol Chem 287 (40) 33905-33916 [2012-09-28; online 2012-08-06]

PubMed DOI Crossref

Antiparallel dimers of the small multidrug resistance protein EmrE are more stable than parallel dimers.

Lloris-Garcerá P, Bianchi F, Slusky JS, ..., Daley DO, von Heijne G

J Biol Chem 287 (31) 26052-26059 [2012-07-27; online 2012-06-14]

PubMed DOI Crossref

Use of structural phylogenetic networks for classification of the ferritin-like superfamily.

Lundin D, Poole AM, Sjöberg BM, Högbom M

J Biol Chem 287 (24) 20565-20575 [2012-06-08; online 2012-04-25]

PubMed DOI Crossref

Efficient glycosylphosphatidylinositol (GPI) modification of membrane proteins requires a C-terminal anchoring signal of marginal hydrophobicity.

Galian C, Björkholm P, Bulleid N, von Heijne G

J Biol Chem 287 (20) 16399-16409 [2012-05-11; online 2012-03-19]

PubMed DOI Crossref

Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.

Lönn P, Vanlandewijck M, Raja E, ..., Heldin CH, Moustakas A

J Biol Chem 287 (16) 12867-12878 [2012-04-13; online 2012-02-29]

PubMed DOI Crossref

Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells.

Forsberg M, Holmborn K, Kundu S, ..., Kjellén L, Forsberg-Nilsson K

J Biol Chem 287 (14) 10853-10862 [2012-03-30; online 2012-02-01]

PubMed DOI Crossref

Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.

Tan EJ, Thuault S, Caja L, ..., Heldin CH, Moustakas A

J Biol Chem 287 (10) 7134-7145 [2012-03-02; online 2012-01-11]

Year 2011

PubMed DOI Crossref

Flanking residues help determine whether a hydrophobic segment adopts a monotopic or bitopic topology in the endoplasmic reticulum membrane.

Nørholm MH, Shulga YV, Aoki S, Epand RM, von Heijne G

J Biol Chem 286 (28) 25284-25290 [2011-07-15; online 2011-05-23]

PubMed DOI Crossref

Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells.

Barkefors I, Fuchs PF, Heldin J, ..., Forsberg-Nilsson K, Kreuger J

J Biol Chem 286 (27) 24189-24199 [2011-07-08; online 2011-05-12]

PubMed DOI Crossref

TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death.

van der Heide LP, van Dinther M, Moustakas A, ten Dijke P

J Biol Chem 286 (7) 5003-5011 [2011-02-18; online 2010-11-24]

Year 2010

PubMed DOI Crossref

Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression.

Akerfelt M, Vihervaara A, Laiho A, ..., Sistonen L, Henriksson E

J Biol Chem 285 (45) 34469-34476 [2010-11-05; online 2010-08-27]

Anniina Vihervaara SciLifeLab Fellow