Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype.

Warnecke A, Musunuri S, N'diaye M, Sandalova T, Achour A, Bergquist J, Harris RA

J. Neuroimmunol. 303 (-) 1-12 [2017-02-15; online 2016-11-26]

Post-translational modifications of autoantigens are hypothesized to affect their immunogenicity. We here report that nitration of tyrosine 40 in Myelin Oligodendrocyte Glycoprotein (MOG) abrogates its encephalitogenicity both at protein and peptide levels in the experimental autoimmune encephalomyelitis (EAE) model in H2

Affiliated researcher

PubMed 28011088

DOI 10.1016/j.jneuroim.2016.11.008

Crossref 10.1016/j.jneuroim.2016.11.008

pii: S0165-5728(16)30422-2

Publications 9.5.0