Membrane vesiculation induced by proteins of the dengue virus envelope studied by molecular dynamics simulations.

de Oliveira Dos Santos Soares R, Bortot LO, van der Spoel D, Caliri A

J Phys Condens Matter 29 (50) 504002 [2017-12-20; online 2017-11-11]

Biological membranes are continuously remodeled in the cell by specific membrane-shaping machineries to form, for example, tubes and vesicles. We examine fundamental mechanisms involved in the vesiculation processes induced by a cluster of envelope (E) and membrane (M) proteins of the dengue virus (DENV) using molecular dynamics simulations and a coarse-grained model. We show that an arrangement of three E-M heterotetramers (EM

Affiliated researcher

PubMed 29125472

DOI 10.1088/1361-648X/aa99c6

Crossref 10.1088/1361-648X/aa99c6

Publications 7.1.2