Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).

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Sammak S, Zinzalla G

Prog. Biophys. Mol. Biol. 119 (1) 41-46 [2015-10-00; online 2015-06-27]

In this review we discuss recent progress in targeting the protein-protein interactions made by oncogenic transcription factors. We particularly focus on the challenges posed by the prevalence of intrinsically disordered regions in this class of protein and the strategies being used to overcome them.

Affiliated researcher

PubMed 26126425

DOI 10.1016/j.pbiomolbio.2015.06.004

Crossref 10.1016/j.pbiomolbio.2015.06.004

pii: S0079-6107(15)00079-6