Lynn Kamerlin SC

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Family name Lynn Kamerlin
Given name Shina Caroline
Initials SC
ORCID

ORCID 0000-0002-3190-1173
Affiliations Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, BMC Box 576, S-751 24 Uppsala, Sweden

35 publications

PubMed DOI Crossref
The need to implement FAIR principles in biomolecular simulations.
Amaro RE, Åqvist J, Bahar I, ..., Zacharias M, Orozco M
Nat. Methods 22 (4) 641-645 [2025-04-00; online 2025-04-03]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Targeting MarA N-terminal domain dynamics to prevent DNA binding.
Corbella M, Moreira C, Bello-Madruga R, ..., Blair JMA, Sancho-Vaello E
Protein Sci. 34 (1) e5258 [2025-01-00; online 2024-12-11]
PubMed DOI Crossref
SHP-1 Variants Broaden the Understanding of pH-Dependent Activities in Protein Tyrosine Phosphatases.
Shen R, Brownless AR, Alansson N, ..., Kamerlin SCL, Hengge AC
JACS Au 4 (8) 2874-2885 [2024-08-26; online 2024-07-17]
DOI Crossref
The N-terminal helix of MarA as a key element in the mechanism of DNA binding
Corbella M, Moreira C, Bello-Madruga R, ..., Blair JMA, Sancho-Vaello E
- - (-) - [2024-02-13; online 2024-02-13]
PubMed DOI Crossref
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation.
Fisher G, Corbella M, Alphey MS, ..., Kamerlin SCL, da Silva RG
Nat Commun 13 (1) 7607 [2022-12-09; online 2022-12-09]
PubMed DOI Crossref
Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Shen R, Crean RM, Olsen KJ, ..., Kamerlin SCL, Hengge AC
Chem Sci 13 (45) 13524-13540 [2022-11-23; online 2022-10-26]
PubMed DOI Crossref
Correction to "Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases".
Crean RM, Biler M, Corbella M, ..., Hengge AC, Kamerlin SCL
Journal of the American Chemical Society 144 (22) 10091-10093 [2022-06-08; online 2022-05-24]
PubMed DOI Crossref
The N-terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition.
Corbella M, Liao Q, Moreira C, ..., Kasson PM, Kamerlin SCL
J Phys Chem B 125 (25) 6791-6806 [2021-07-01; online 2021-06-17]
PubMed DOI Crossref
Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Shen R, Crean RM, Johnson SJ, Kamerlin SCL, Hengge AC
JACS Au 1 (5) 646-659 [2021-05-24; online 2021-04-23]
DOI Crossref
A Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases
Shen R, Crean R, Johnson S, Kamerlin SCL, Hengge AC
- - (-) - [2021-04-05; online 2021-04-05]
PubMed DOI Crossref
Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases.
Crean RM, Biler M, van der Kamp MW, Hengge AC, Kamerlin SCL
Journal of the American Chemical Society 143 (10) 3830-3845 [2021-03-17; online 2021-03-04]
DOI Crossref
Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases
Crean R, Biler M, van der Kamp M, Hengge AC, Kamerlin SCL
- - (-) - [2021-02-04; online 2021-02-04]
DOI Crossref
The N-Terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition
Corbella M, Liao Q, Moreira C, Kasson PM, Kamerlin SCL
- - (-) - [2021-01-29; online 2021-01-29]
DOI Crossref
A Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases
Shen R, Crean R, Johnson S, Kamerlin SCL, Hengge AC
- - (-) - [2021-01-19; online 2021-01-19]
PubMed DOI Crossref
Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.
Gamiz-Arco G, Gutierrez-Rus LI, Risso VA, ..., Gaucher EA, Sanchez-Ruiz JM
Nat Commun 12 (1) 380 [2021-01-15; online 2021-01-15]
DOI Crossref
Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases
Crean R, Biler M, van der Kamp M, Hengge AC, Kamerlin SCL
- - (-) - [2020-11-12; online 2020-11-12]
PubMed DOI Crossref
Enhancing a de novo enzyme activity by computationally-focused ultra-low-throughput screening.
Risso VA, Romero-Rivera A, Gutierrez-Rus LI, ..., Sanchez-Ruiz JM, Kamerlin SCL
Chem Sci 11 (24) 6134-6148 [2020-06-28; online 2020-05-19]
DOI Crossref
The N-Terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition
Corbella M, Liao Q, Kasson PM, Kamerlin SCL
- - (-) - [2020-04-27; online 2020-04-27]
DOI Crossref
Intervention strategies against COVID-19 and their estimated impact on Swedish healthcare capacity
Gardner JM, Willem L, Van Der Wijngaart W, ..., Brusselaers N, Kasson P
- - (-) - [2020-04-15; online 2020-04-15]
DOI Crossref
Enhancing a De Novo Enzyme Activity by Computationally-Focused, Ultra-Low-Throughput Sequence Screening
Risso VA, Romero-Rivera A, Gutierrez-Rus LI, ..., Sanchez Ruiz JM, Kamerlin SCL
- - (-) - [2020-04-06; online 2020-04-06]
PubMed DOI Crossref
Short and simple sequences favored the emergence of N-helix phospho-ligand binding sites in the first enzymes.
Longo LM, Petrović D, Kamerlin SCL, Tawfik DS
Proc. Natl. Acad. Sci. U.S.A. 117 (10) 5310-5318 [2020-03-10; online 2020-02-20]
PubMed DOI Crossref
Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase.
Kulkarni YS, Amyes TL, Richard JP, Kamerlin SCL
Journal of the American Chemical Society 141 (40) 16139-16150 [2019-10-09; online 2019-09-25]
DOI Crossref
Uncovering the Role of Key Active Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalysed by Wild-Type and Variants of Triosephosphate Isomerase
Kulkarni YS, Amyes TL, Richard J, Kamerlin SCL
- - (-) - [2019-08-13; online 2019-08-13]
PubMed DOI Crossref
Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition.
Liao Q, Lüking M, Krüger DM, ..., Kasson PM, Lynn Kamerlin SC
J Phys Chem B 123 (17) 3576-3590 [2019-05-02; online 2019-04-18]
SciLifeLab Fellow Sebastian Deindl
PubMed DOI Crossref
Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies.
Mydy LS, Cristobal JR, Katigbak RD, ..., Richard JP, Gulick AM
Biochemistry 58 (8) 1061-1073 [2019-02-26; online 2019-01-31]
DOI Crossref
Higher-order epistatic networks underlie the evolutionary fitness landscape of a xenobiotic-degrading enzyme
Yang G, Anderson DW, Baier F, ..., Bornberg-Bauer E, Tokuriki N
- - (-) - [2018-12-26; online 2018-12-26]
PubMed DOI Crossref
Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme.
Janfalk Carlsson Å, Bauer P, Dobritzsch D, Kamerlin SCL, Widersten M
IUCrJ 5 (Pt 3) 269-282 [2018-05-01; online 2018-03-22]
PubMed DOI Crossref
Computer simulations of the catalytic mechanism of wild-type and mutant β-phosphoglucomutase.
Barrozo A, Liao Q, Esguerra M, ..., Williams NH, Kamerlin SCL
Org. Biomol. Chem. 16 (12) 2060-2073 [2018-03-28; online 2018-03-06]
PubMed DOI Crossref
Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase.
Kulkarni YS, Liao Q, Byléhn F, ..., Richard JP, Kamerlin SCL
Journal of the American Chemical Society 140 (11) 3854-3857 [2018-03-21; online 2018-03-13]
PubMed DOI Crossref
Similar Active Sites and Mechanisms Do Not Lead to Cross-Promiscuity in Organophosphate Hydrolysis: Implications for Biotherapeutic Engineering.
Purg M, Elias M, Kamerlin SCL
Journal of the American Chemical Society 139 (48) 17533-17546 [2017-12-06; online 2017-11-21]
PubMed DOI Crossref
Extending the Nonbonded Cationic Dummy Model to Account for Ion-Induced Dipole Interactions.
Liao Q, Pabis A, Strodel B, Kamerlin SCL
J Phys Chem Lett 8 (21) 5408-5414 [2017-11-02; online 2017-10-23]
PubMed DOI Crossref
DNA Polymerase λ Active Site Favors a Mutagenic Mispair between the Enol Form of Deoxyguanosine Triphosphate Substrate and the Keto Form of Thymidine Template: A Free Energy Perturbation Study.
Maximoff SN, Kamerlin SCL, Florián J
J Phys Chem B 121 (33) 7813-7822 [2017-08-24; online 2017-08-14]
PubMed DOI Crossref
Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase.
Kulkarni YS, Liao Q, Petrović D, ..., Richard JP, Kamerlin SCL
Journal of the American Chemical Society 139 (30) 10514-10525 [2017-08-02; online 2017-07-19]
PubMed DOI Crossref
Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1.
Blaha-Nelson D, Krüger DM, Szeler K, Ben-David M, Kamerlin SC
Journal of the American Chemical Society 139 (3) 1155-1167 [2017-01-25; online 2017-01-11]
PubMed DOI Crossref
Probing the mechanisms for the selectivity and promiscuity of methyl parathion hydrolase.
Purg M, Pabis A, Baier F, ..., Jackson C, Kamerlin SC
Philos Trans A Math Phys Eng Sci 374 (2080) - [2016-11-13; online 2016-10-05]
SciLifeLab Data Centre
Publications 9.5.1