Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning.

Mohammadi E, Benfeitas R, Turkez H, Boren J, Nielsen J, Uhlen M, Mardinoglu A

Cancers (Basel) 12 (9) - [2020-09-21; online 2020-09-21]

Modern drug discovery through de novo drug discovery entails high financial costs, low success rates, and lengthy trial periods. Drug repositioning presents a suitable approach for overcoming these issues by re-evaluating biological targets and modes of action of approved drugs. Coupling high-throughput technologies with genome-wide essentiality screens, network analysis, genome-scale metabolic modeling, and machine learning techniques enables the proposal of new drug-target signatures and uncovers unanticipated modes of action for available drugs. Here, we discuss the current issues associated with drug repositioning in light of curated high-throughput multi-omic databases, genome-wide screening technologies, and their application in systems biology/medicine approaches.

Adil Mardinoglu

SciLifeLab Fellow

PubMed 32967266

DOI 10.3390/cancers12092694

Crossref 10.3390/cancers12092694

pii: cancers12092694
pmc: PMC7563533

Publications 9.5.0