Shi L, Han Y, Hilborn J, Ossipov D
Chem. Commun. (Camb.) 52 (74) 11151-11154 [2016-09-25; online 2016-08-23]
We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium-bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.