"Smart" drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium-biopolymer chemistry.
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Shi L, Han Y, Hilborn J, Ossipov D
Chem. Commun. (Camb.) 52 (74) 11151-11154 [2016-09-25; online 2016-08-23]
We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium-bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.
PubMed 27550535
DOI 10.1039/c6cc05565f
Crossref 10.1039/c6cc05565f