Spjuth O

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Family name Spjuth
Given name Ola
Initials O
ORCID

ORCID 0000-0002-8083-2864
Affiliations Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, 75124, Sweden.

57 publications

DOI Crossref
The time dimension matters: Improving mode of action classification with live-cell imaging
Forsgren E, Rietdijk J, Holmberg D, ..., Spjuth O, Jonsson P
Artificial Intelligence in the Life Sciences 9 (-) 100152 [2026-06-00; online 2026-06-00]
DOI Crossref
Small molecule bioactivity benchmarks are often well-predicted by counting cells
Seal S, Dee W, Shah A, ..., Bender A, Carpenter AE
- - (-) - [2025-04-30; online 2025-04-30]
DOI Crossref
The time dimension matters: Improving mode of action classification with live-cell imaging
Forsgren E, Rietdijk J, Holmberg D, ..., Spjuth O, Jonsson P
- - (-) - [2025-04-24; online 2025-04-24]
PubMed DOI Crossref
Author Correction: Cell Painting: a decade of discovery and innovation in cellular imaging.
Seal S, Trapotsi MA, Spjuth O, ..., Bender A, Carpenter AE
Nat. Methods 22 (2) 447 [2025-02-00; online 2024-12-13]
PubMed DOI Crossref
Cell Painting: a decade of discovery and innovation in cellular imaging.
Seal S, Trapotsi MA, Spjuth O, ..., Bender A, Carpenter AE
Nat. Methods 22 (2) 254-268 [2025-02-00; online 2024-12-05]
DOI Crossref
Single-Cell Morphological Profiling Reveals Insights into Programmed Cell Death
Frey B, Holmberg D, Byström P, ..., Carreras-Puigvert J, Spjuth O
- - (-) - [2025-01-19; online 2025-01-19]
DOI Crossref
Minimising Source-Plate Swaps for Robotised Compound Dispensing in Microplates
Gindullin R, Francisco Rodríguez MA, Seashore-Ludlow B, Spjuth O
- - (-) 256-273 [2025-00-00; online 2025-06-29]
DOI Crossref
Comparing Lipinskis Rule of 5 and Machine Learning Based Prediction of Fraction Absorbed for Assessing Oral Absorption in Humans
Fagerholm U, Hellberg S, Alvarsson J, Ekmefjord M, Spjuth O
- - (-) - [2024-08-23; online 2024-08-23]
PubMed DOI Crossref
Improved Detection of Drug-Induced Liver Injury by Integrating Predicted in vivo and in vitro Data.
Seal S, Williams DP, Hosseini-Gerami L, ..., Spjuth O, Bender A
bioRxiv - (-) - [2024-06-08; online 2024-06-08]
PubMed DOI Crossref
A Decade in a Systematic Review: The Evolution and Impact of Cell Painting.
Seal S, Trapotsi MA, Spjuth O, ..., Bender A, Carpenter AE
bioRxiv - (-) - [2024-05-07; online 2024-05-07]
DOI Crossref
Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis
Sreenivasan AP, Vaivade A, Noui Y, ..., Spjuth O, Kultima K
- - (-) - [2024-03-02; online 2024-03-02]
PubMed DOI Crossref
From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability.
Seal S, Carreras-Puigvert J, Singh S, ..., Spjuth O, Bender A
Mol. Biol. Cell 35 (3) mr2 [2024-03-01; online 2024-01-03]
DOI Crossref
PKSmart: An Open-Source Computational Model to Predict in vivo Pharmacokinetics of Small Molecules
Seal S, Trapotsi MA, Subramanian V, ..., Greene N, Bender A
- - (-) - [2024-02-07; online 2024-02-07]
DOI Crossref
CPSign - Conformal Prediction for Cheminformatics Modeling
McShane SA, Norinder U, Alvarsson J, ..., Carlsson L, Spjuth O
- - (-) - [2023-11-22; online 2023-11-22]
PubMed DOI Crossref
ELIXIR and Toxicology: a community in development.
Martens M, Stierum R, Schymanski EL, ..., Županič A, Willighagen EL
F1000Res 10 (-) - [2023-10-03; online 2023-10-03]
DOI Crossref
Exploring the morphology of the host cell to open new possibilities for drug repurposing in viral infections
Tampere M, Kalman A, Rietdijk J, ..., Stadler C, Östling P
- - (-) - [2023-09-28; online 2023-09-28]
PubMed DOI Crossref
Author Correction: A method for Boolean analysis of protein interactions at a molecular level.
Raykova D, Kermpatsou D, Malmqvist T, ..., Kampf C, Söderberg O
Nat Commun 14 (1) 5450 [2023-09-06; online 2023-09-06]
DOI Crossref
From Pixels to Phenotypes: Integrating Image-Based Profiling with Cell Health Data Improves Interpretability
Seal S, Carreras-Puigvert J, Carpenter AE, Spjuth O, Bender A
- - (-) - [2023-07-16; online 2023-07-16]
PubMed DOI Crossref
Evaluating the utility of brightfield image data for mechanism of action prediction.
Harrison PJ, Gupta A, Rietdijk J, ..., Spjuth O, Sintorn IM
PLoS Comput Biol 19 (7) e1011323 [2023-07-00; online 2023-07-25]
DOI Crossref
Prediction of the Human Pharmacokinetics of 30 Modern Antibiotics Using the ANDROMEDA Software
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2023-03-29; online 2023-03-29]
DOI Crossref
Application of the ANDROMEDA Software for Prediction of the Human Pharmacokinetics of Modern Anticancer Drugs
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2023-03-21; online 2023-03-21]
PubMed DOI Crossref
Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction.
Olsson H, Kartasalo K, Mulliqi N, ..., Spjuth O, Eklund M
Nat Commun 13 (1) 7761 [2022-12-15; online 2022-12-15]
DDLS Fellow Kimmo Kartasalo
DOI Crossref
Predicting the Influence of Fat Food Intake on the Absorption and Systemic Exposure of Small Drugs using ANDROMEDA by Prosilico Software
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2022-12-08; online 2022-12-08]
DOI Crossref
Predicting Gastrointestinal Absorption of Prodrugs and their Drugs with the ANDROMEDA by Prosilico Software
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2022-11-25; online 2022-11-25]
DOI Crossref
Validation of predicted conformal intervals for prediction of human clinical pharmacokinetics
Fagerholm U, Alvarsson J, Hellberg S, Spjuth O
- - (-) - [2022-11-13; online 2022-11-13]
DOI Crossref
Is brightfield all you need for mechanism of action prediction?
Gupta A, Harrison PJ, Wieslander H, ..., Spjuth O, Sintorn IM
- - (-) - [2022-10-13; online 2022-10-13]
DOI Crossref
ANDROMEDA by Prosilico Software Successfully Predicts Human Clinical Pharmacokinetics of 300 Drugs Out of Reach for In Vitro Methods
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2022-10-07; online 2022-10-07]
DOI Crossref
Prediction and Classification of the Uptake and Disposition of Antidepressants and New CNS-Active Drugs in the Human Brain using the ANDROMEDA by Prosilico Software and Brainavailability-Matrix
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2022-09-30; online 2022-09-30]
DOI Crossref
Prediction of Biopharmaceutical Characteristics of PROTACs using the ANDROMEDA by Prosilico Software
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2022-09-23; online 2022-09-23]
PubMed DOI Crossref
From biomedical cloud platforms to microservices: next steps in FAIR data and analysis.
Sheffield NC, Bonazzi VR, Bourne PE, ..., Spjuth O, Yates AD
Sci Data 9 (1) 553 [2022-09-08; online 2022-09-08]
PubMed DOI Crossref
Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection.
Seal S, Carreras-Puigvert J, Trapotsi MA, ..., Spjuth O, Bender A
Commun Biol 5 (1) 858 [2022-08-23; online 2022-08-23]
DOI Crossref
Using the ANDROMEDA by Prosilico Software for Prediction of the Human Pharmacokinetics of 4 Compounds of Natural Origin - Colistin, Curucumin, UCN-01 and Voclosporin
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
- - (-) - [2022-08-17; online 2022-08-17]
DOI Crossref
Merging Bioactivity Predictions from Cell Morphology and Chemical Fingerprint Models Using Similarity to Training Data
Seal S, Yang H, Trapotsi MA, ..., Spjuth O, Bender A
- - (-) - [2022-08-15; online 2022-08-15]
PubMed DOI Crossref
SimVec: predicting polypharmacy side effects for new drugs.
Lukashina N, Kartysheva E, Spjuth O, Virko E, Shpilman A
J Cheminform 14 (1) 49 [2022-07-26; online 2022-07-26]
DOI Crossref
Designing microplate layouts using artificial intelligence
Francisco Rodríguez MA, Puigvert JC, Spjuth O
- - (-) - [2022-04-01; online 2022-04-01]
DOI Crossref
Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects
Rietdijk J, Aggarwal T, Georgieva P, ..., Carreras-Puigvert J, Spjuth O
- - (-) - [2022-02-10; online 2022-02-10]
PubMed DOI Crossref
In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology.
Fagerholm U, Hellberg S, Alvarsson J, Spjuth O
Xenobiotica 52 (2) 113-118 [2022-02-00; online 2022-03-16]
DOI Crossref
Integrating Cell Morphology with Gene Expression and Chemical Structure to Aid Mitochondrial Toxicity Detection
Seal S, Carreras-Puigvert J, Trapotsi MA, ..., Spjuth O, Bender A
- - (-) - [2022-01-07; online 2022-01-07]
PubMed DOI Crossref
In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models.
Fagerholm U, Hellberg S, Alvarsson J, Arvidsson McShane S, Spjuth O
Xenobiotica 51 (12) 1366-1371 [2021-12-00; online 2021-12-08]
DOI Crossref
ELIXIR and Toxicology: a community in development
Martens M, Stierum R, Schymanski EL, ..., Županič A, Willighagen EL
F1000Res 10 (-) 1129 [2021-11-08; online 2021-11-08]
PubMed DOI Crossref
Synergy conformal prediction applied to large-scale bioactivity datasets and in federated learning.
Norinder U, Spjuth O, Svensson F
J Cheminform 13 (1) 77 [2021-10-02; online 2021-10-02]
PubMed DOI Crossref
Comparison between lab variability and in silico prediction errors for the unbound fraction of drugs in human plasma.
Fagerholm U, Spjuth O, Hellberg S
Xenobiotica 51 (10) 1095-1100 [2021-10-00; online 2021-08-13]
PubMed DOI Crossref
The machine learning life cycle and the cloud: implications for drug discovery.
Spjuth O, Frid J, Hellander A
Expert Opin Drug Discov 16 (9) 1071-1079 [2021-09-00; online 2021-05-31]
PubMed DOI Crossref
Machine Learning Strategies When Transitioning between Biological Assays.
Arvidsson McShane S, Ahlberg E, Noeske T, Spjuth O
J Chem Inf Model 61 (7) 3722-3733 [2021-07-26; online 2021-06-21]
DOI Crossref
An Open-Source Modular Framework for Automated Pipetting and Imaging Applications
Ouyang W, Bowman R, Wang H, ..., Carreras-Puigvert J, Diederich B
- - (-) - [2021-06-24; online 2021-06-24]
PubMed DOI Crossref
Assessing the calibration in toxicological in vitro models with conformal prediction.
Morger A, Svensson F, Arvidsson McShane S, ..., Spjuth O, Volkamer A
J Cheminform 13 (1) 35 [2021-04-29; online 2021-04-29]
PubMed DOI Crossref
Advances in Predictions of Oral Bioavailability of Candidate Drugs in Man with New Machine Learning Methodology.
Fagerholm U, Hellberg S, Spjuth O
Molecules 26 (9) - [2021-04-28; online 2021-04-28]
DOI Crossref
A phenomics approach for in vitro antiviral drug discovery
Rietdijk J, Tampere M, Pettke A, ..., Puumalainen MR, Carreras-Puigvert J
- - (-) - [2021-01-13; online 2021-01-13]
DOI Crossref
Rapid development of cloud-native intelligent data pipelines for scientific data streams using the HASTE Toolkit
Blamey B, Toor S, Dahlö M, ..., Spjuth O, Hellander A
- - (-) - [2020-09-14; online 2020-09-14]
PubMed DOI Crossref
Using Predicted Bioactivity Profiles to Improve Predictive Modeling.
Norinder U, Spjuth O, Svensson F
J Chem Inf Model 60 (6) 2830-2837 [2020-06-22; online 2020-05-15]
DOI Crossref
Deep learning models for lipid-nanoparticle-based drug delivery
Harrison PJ, Wieslander H, Sabirsh A, ..., Wählby C, Spjuth O
- - (-) - [2020-04-07; online 2020-04-07]
DOI Crossref
Approaches for Containerized Scientific Workflows in Cloud Environments with Applications in Life Science
Spjuth O, Capuccini M, Carone M, ..., Kultima K, Lampa S
- - (-) - [2020-01-31; online 2020-01-31]
PubMed DOI Crossref
Deep Learning in Image Cytometry: A Review.
Gupta A, Harrison PJ, Wieslander H, ..., Sintorn I, Wählby C
Cytometry A 95 (4) 366-380 [2019-04-00; online 2018-12-19]
DDLS Fellow Kimmo Kartasalo
PubMed DOI Crossref
Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing⁻Remitting Multiple Sclerosis.
Herman S, Åkerfeldt T, Spjuth O, Burman J, Kultima K
Cells 8 (2) - [2019-01-24; online 2019-01-24]
DOI Crossref
Galaxy-Kubernetes integration: scaling bioinformatics workflows in the cloud
Moreno P, Pireddu L, Roger P, ..., Spjuth O, Neumann S
- - (-) - [2018-12-07; online 2018-12-07]
DOI Crossref
SciPipe - A workflow library for agile development of complex and dynamic bioinformatics pipelines
Lampa S, Dahlö M, Alvarsson J, Spjuth O
- - (-) - [2018-08-01; online 2018-08-01]
DOI Crossref
Container-based bioinformatics with Pachyderm
Novella JA, Khoonsari PE, Herman S, ..., Kultima K, Spjuth O
- - (-) - [2018-04-18; online 2018-04-18]
SciLifeLab Data Centre
Publications 9.5.1