Danielson UH

Family name	Danielson
Given name	U Helena
Initials	UH
ORCID	ORCID 0000-0003-2728-0340
Affiliations	Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, SE-75123 Uppsala, Sweden.

20 publications

PubMed DOI Crossref

Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography.

FitzGerald EA, Cederfelt D, Kovryzhenko D, ..., de Esch IJP, Danielson UH

RSC Chem Biol 6 (10) 1625-1639 [2025-10-01; online 2025-08-13]

PubMed DOI Crossref

Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications.

Pérez-Ràfols A, Pérez-Ropero G, Cerofolini L, ..., Buijs J, Fragai M

Nucleic Acids Res. 53 (15) - [2025-08-11; online 2025-08-13]

PubMed DOI Crossref

Regulatory Effects of RNA-Protein Interactions Revealed by Reporter Assays of Bacteria Grown on Solid Media.

Pérez-Ropero G, Dolcemascolo R, Pérez-Ràfols A, ..., Rodrigo G, Buijs J

Biosensors (Basel) 15 (3) - [2025-03-08; online 2025-03-08]

PubMed DOI Crossref

The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity.

Blaazer AR, Singh AK, Zara L, ..., Brown DG, de Esch IJP

ChemMedChem 19 (22) e202400417 [2024-11-18; online 2024-09-12]

PubMed DOI Crossref

Unraveling the Bivalent and Rapid Interactions Between a Multivalent RNA Recognition Motif and RNA: A Kinetic Approach.

Pérez-Ropero G, Pérez-Ràfols A, Martelli T, Danielson UH, Buijs J

Biochemistry 63 (21) 2816-2829 [2024-11-05; online 2024-10-14]

PubMed DOI Crossref

Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening.

FitzGerald EA, Cederfelt D, Lund BA, ..., Dobritzsch D, Danielson UH

RSC Med Chem 15 (6) 1982-1990 [2024-06-19; online 2024-03-20]

PubMed DOI Crossref

The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase.

Fekry M, Dave KK, Badgujar D, ..., Dobritzsch D, Danielson UH

Biomolecules 13 (9) - [2023-09-07; online 2023-09-07]

PubMed DOI Crossref

Monitoring drug-target interactions through target engagement-mediated amplification on arrays and in situ.

Al-Amin RA, Johansson L, Abdurakhmanov E, ..., Lundbäck T, Landegren U

Nucleic Acids Res. 50 (22) e129 [2022-12-09; online 2022-10-04]

PubMed DOI Crossref

Sensitive Protein Detection Using Site-Specifically Oligonucleotide-Conjugated Nanobodies.

Al-Amin RA, Muthelo PM, Abdurakhmanov E, ..., Danielson UH, Landegren U

Anal. Chem. 94 (28) 10054-10061 [2022-07-19; online 2022-07-05]

PubMed DOI Crossref

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.

Luttens A, Gullberg H, Abdurakhmanov E, ..., Danielson UH, Carlsson J

Journal of the American Chemical Society 144 (7) 2905-2920 [2022-02-23; online 2022-02-10]

Andreas Luttens DDLS Fellow Jens Carlsson SciLifeLab Fellow

DOI Crossref

Monitoring Drug-Target Interactions through Target Engagement-Mediated Amplification on Arrays and in situ

Al-Amin R, Johansson L, Abdurakhmanov E, ..., Lundbäck T, Landegren U

- - (-) - [2021-12-06; online 2021-12-06]

PubMed DOI Crossref

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase.

Talibov VO, Fabini E, FitzGerald EA, ..., Del Rio A, Danielson UH

Chembiochem 22 (9) 1597-1608 [2021-05-04; online 2021-02-11]

PubMed DOI Crossref

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor.

FitzGerald EA, Butko MT, Boronat P, ..., Young T, Danielson UH

RSC Adv. 11 (13) 7527-7537 [2021-02-10; online 2021-02-17]

DOI Crossref

Multiplexed experimental strategies for fragment library screening using SPR biosensors

FitzGerald EA, Vagrys D, Opassi G, ..., de Esch IJP, Danielson UH

- - (-) - [2020-12-23; online 2020-12-23]

PubMed DOI Crossref

Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment-based lead discovery.

Opassi G, Nordström H, Lundin A, ..., Klebe G, Danielson UH

Protein Sci. 29 (4) 991-1003 [2020-04-00; online 2020-02-07]

PubMed DOI Crossref

Estimating Detection Limits of Potentiometric DNA Sensors Using Surface Plasmon Resonance Analyses.

Xu X, Makaraviciute A, Abdurakhmanov E, ..., Nyholm L, Zhang Z

ACS Sens 5 (1) 217-224 [2020-01-24; online 2019-12-23]

PubMed DOI Crossref

Unveiling the Biochemistry of the Epigenetic Regulator SMYD3.

Fabini E, Talibov VO, Mihalic F, ..., Del Rio A, Danielson UH

Biochemistry 58 (35) 3634-3645 [2019-09-03; online 2019-08-21]

PubMed DOI Crossref

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.

Linkuvienė V, Talibov VO, Danielson UH, Matulis D

J Med Chem 61 (6) 2292-2302 [2018-03-22; online 2018-03-02]

PubMed DOI Crossref

Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.

Solbak SMØ, Abdurakhmanov E, Vedeler A, Danielson UH

Virol. J. 14 (1) 236 [2017-12-11; online 2017-12-11]

PubMed DOI Crossref

Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+ /calmodulin-dependent kinase II.

Seeger C, Talibov VO, Danielson UH

J. Mol. Recognit. 30 (8) - [2017-08-00; online 2017-04-27]