Intracellular drug bioavailability: a new predictor of system dependent drug disposition.

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Mateus A, Treyer A, Wegler C, Karlgren M, Matsson P, Artursson P

Sci Rep 7 (-) 43047 [2017-02-22; online 2017-02-22]

Intracellular drug exposure is influenced by cell- and tissue-dependent expression of drug-transporting proteins and metabolizing enzymes. Here, we introduce the concept of intracellular bioavailability (F

Affiliated researcher

PubMed 28225057

DOI 10.1038/srep43047

Crossref 10.1038/srep43047

pii: srep43047
pmc: PMC5320532