InParanoid 8: orthology analysis between 273 proteomes, mostly eukaryotic.

Sonnhammer EL, Östlund G

Nucleic Acids Res. 43 (Database issue) D234-D239 [2015-01-00; online 2014-11-27]

The InParanoid database ( provides a user interface to orthologs inferred by the InParanoid algorithm. As there are now international efforts to curate and standardize complete proteomes, we have switched to using these resources rather than gathering and curating the proteomes ourselves. InParanoid release 8 is based on the 66 reference proteomes that the 'Quest for Orthologs' community has agreed on using, plus 207 additional proteomes from the UniProt complete proteomes--in total 273 species. These represent 246 eukaryotes, 20 bacteria and seven archaea. Compared to the previous release, this increases the number of species by 173% and the number of pairwise species comparisons by 650%. In turn, the number of ortholog groups has increased by 423%. We present the contents and usages of InParanoid 8, and a detailed analysis of how the proteome content has changed since the previous release.

Affiliated researcher

PubMed 25429972

DOI 10.1093/nar/gku1203

Crossref 10.1093/nar/gku1203

pii: gku1203
pmc: PMC4383983

Publications 9.5.0