Niroula A

JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism.

Zon RL, Sekar A, Clapham K, ..., Natarajan P, Ebert BL

Blood 144 (20) 2149-2154 [2024-11-14; online 2024-08-05]

Abhishek Niroula DDLS Fellow

Sequence variants influencing the regulation of serum IgG subclass levels.

Olafsdottir TA, Thorleifsson G, Lopez de Lapuente Portilla A, ..., Nilsson B, Stefansson K

Nat Commun 15 (1) 8054 [2024-09-14; online 2024-09-14]

Abhishek Niroula DDLS Fellow

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis.

Uddin MM, Saadatagah S, Niroula A, ..., Ballantyne CM, Natarajan P

Nat Commun 15 (1) 7858 [2024-09-09; online 2024-09-09]

Abhishek Niroula DDLS Fellow

Deciphering the genetics and mechanisms of predisposition to multiple myeloma.

Went M, Duran-Lozano L, Halldorsson GH, ..., Houlston R, Nilsson B

Nat Commun 15 (1) 6644 [2024-08-05; online 2024-08-05]

Abhishek Niroula DDLS Fellow

Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1.

Saadatagah S, Naderian M, Uddin M, ..., Kullo IJ, Ballantyne CM

JAMA Cardiol 9 (6) 497-506 [2024-06-01; online 2024-04-10]

Abhishek Niroula DDLS Fellow

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.

Lin AE, Bapat AC, Xiao L, ..., Ellinor PT, Ebert BL

Circulation 149 (18) 1419-1434 [2024-04-30; online 2024-02-15]

Abhishek Niroula DDLS Fellow

Association of Somatic TET2 Mutations With Giant Cell Arteritis.

Robinette ML, Weeks LD, Kramer RJ, ..., Rao DA, Ebert BL

Arthritis & rheumatology (Hoboken, N.J.) 76 (3) 438-443 [2024-03-00; online 2024-02-02]

Abhishek Niroula DDLS Fellow

Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV: a report from the REPRIEVE trial.

Bhattacharya R, Uddin MM, Patel AP, ..., Grinspoon SK, Natarajan P

Blood Adv 8 (4) 959-967 [2024-02-27; online 2024-01-10]

Abhishek Niroula DDLS Fellow

SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.

Chen CW, Zhang L, Dutta R, ..., Sperling AS, Goodell MA

Cell Stem Cell 30 (11) 1503-1519.e8 [2023-11-02; online 2023-10-19]

Abhishek Niroula DDLS Fellow

Functional and molecular profiling of hematopoietic stem cells during regeneration.

Rydström A, Grahn THM, Niroula A, ..., Larsson J, Karlsson S

Exp. Hematol. 127 (-) 40-51 [2023-11-00; online 2023-09-04]

Abhishek Niroula DDLS Fellow

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.

Yu Z, Fidler TP, Ruan Y, ..., Tall AR, Natarajan P

J. Clin. Invest. 133 (18) - [2023-09-15; online 2023-09-15]

Abhishek Niroula DDLS Fellow

Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood.

Schuermans A, Nakao T, Ruan Y, ..., Natarajan P, Honigberg MC

J Am Heart Assoc 12 (13) e030220 [2023-07-04; online 2023-06-22]

Abhishek Niroula DDLS Fellow

Clonal Hematopoiesis and Risk of Incident Lung Cancer.

Tian R, Wiley B, Liu J, ..., Bolton KL, Cao Y

J Clin Oncol 41 (7) 1423-1433 [2023-03-01; online 2022-12-08]

Abhishek Niroula DDLS Fellow

Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.

Nakao T, Bick AG, Taub MA, ..., NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium , Natarajan P

Sci Adv 8 (14) eabl6579 [2022-04-08; online 2022-04-06]

Abhishek Niroula DDLS Fellow

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke.

Bhattacharya R, Zekavat SM, Haessler J, ..., Natarajan P, Reiner AP

Stroke 53 (3) 788-797 [2022-03-00; online 2021-11-08]

Abhishek Niroula DDLS Fellow

Association of clonal hematopoiesis with chronic obstructive pulmonary disease.

Miller PG, Qiao D, Rojas-Quintero J, ..., Ebert BL, COPDGene Study Investigators, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium

Blood 139 (3) 357-368 [2022-01-20; online 2021-12-03]

Abhishek Niroula DDLS Fellow

Functional dissection of inherited non-coding variation influencing multiple myeloma risk.

Ajore R, Niroula A, Pertesi M, ..., Houlston R, Nilsson B

Nat Commun 13 (1) 151 [2022-01-10; online 2022-01-10]

Abhishek Niroula DDLS Fellow

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.

Kim PG, Niroula A, Shkolnik V, ..., Natarajan P, Ebert BL

J. Exp. Med. 218 (12) - [2021-12-06; online 2021-10-26]

Abhishek Niroula DDLS Fellow

Distinction of lymphoid and myeloid clonal hematopoiesis.

Niroula A, Sekar A, Murakami MA, ..., Natarajan P, Ebert BL

Nat. Med. 27 (11) 1921-1927 [2021-11-00; online 2021-10-18]

Abhishek Niroula DDLS Fellow

Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing.

Mattsson J, Ekdahl L, Junghus F, ..., Teige I, Nilsson B

Nat Commun 12 (1) 1277 [2021-02-24; online 2021-02-24]

Abhishek Niroula DDLS Fellow

S100A6 is a critical regulator of hematopoietic stem cells.

Grahn THM, Niroula A, Végvári Á, ..., Zubarev RA, Karlsson S

Leukemia 34 (12) 3323-3337 [2020-12-00; online 2020-06-19]

Abhishek Niroula DDLS Fellow

How good are pathogenicity predictors in detecting benign variants?

Niroula A, Vihinen M

PLoS Comput Biol 15 (2) e1006481 [2019-02-00; online 2019-02-11]

Abhishek Niroula DDLS Fellow

The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression.

Ali M, Ajore R, Wihlborg AK, ..., Weinhold N, Nilsson B

Nat Commun 9 (1) 1649 [2018-04-25; online 2018-04-25]

Abhishek Niroula DDLS Fellow

Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI.

Carraro M, Minervini G, Giollo M, ..., Moult J, Tosatto SCE

Hum. Mutat. 38 (9) 1042-1050 [2017-09-00; online 2017-05-16]

Abhishek Niroula DDLS Fellow

Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges.

Daneshjou R, Wang Y, Bromberg Y, ..., Brenner SE, Morgan AA

Hum. Mutat. 38 (9) 1182-1192 [2017-09-00; online 2017-07-07]

Abhishek Niroula DDLS Fellow