Schulte G

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.

Scharf MM, Kinsolving J, Grätz L, ..., Kolb P, Schulte G

Nat Commun 16 (1) 11138 [2025-12-14; online 2025-12-14]

Björn Forsberg DDLS Fellow

In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators

Schulte G, Scharf M, Grätz L, ..., Forsberg B, Kolb P

- - (-) - [2025-08-15; online 2025-08-15]

Björn Forsberg DDLS Fellow

In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators

Schulte G, Scharf M, Grätz L, ..., Forsberg B, Kolb P

- - (-) - [2025-07-17; online 2025-07-17]

Björn Forsberg DDLS Fellow

SAG1.3-derived Frizzled-targeting negative allosteric modulators

Schulte G, Grätz L, Turku A, ..., Löber S, Gmeiner P

- - (-) - [2024-02-20; online 2024-02-20]

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.

Grätz L, Kowalski-Jahn M, Scharf MM, ..., Gloriam DE, Schulte G

Nat Commun 14 (1) 4573 [2023-07-29; online 2023-07-29]

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.

Zhou Y, Arribas GH, Turku A, ..., Gastaldello S, Lauschke VM

Sci Adv 7 (36) eabi6856 [2021-09-03; online 2021-09-01]

DDLS Fellow Yitian Zhou

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.

Wright SC, Kozielewicz P, Kowalski-Jahn M, ..., Carlsson J, Schulte G

Nat Commun 10 (1) 667 [2019-02-08; online 2019-02-08]

Jens Carlsson SciLifeLab Fellow

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC, Cañizal MCA, Benkel T, ..., Schulte G, Hoffmann C

Sci Signal 11 (559) eaar5536 [2018-12-04; online 2018-12-04]

Jens Carlsson SciLifeLab Fellow

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.

Strakova K, Kowalski-Jahn M, Gybel T, ..., Bryja V, Schulte G

J Biol Chem 293 (48) 18477-18493 [2018-11-30; online 2018-10-11]