A systems biology approach for studying neurodegenerative diseases.

Lam S, Bayraktar A, Zhang C, Turkez H, Nielsen J, Boren J, Shoaie S, Uhlen M, Mardinoglu A

Drug Discov. Today 25 (7) 1146-1159 [2020-07-00; online 2020-05-19]

Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.

Adil Mardinoglu

Fellows programme

Saeed Shoaie

PubMed 32442631

DOI 10.1016/j.drudis.2020.05.010

Crossref 10.1016/j.drudis.2020.05.010

pii: S1359-6446(20)30201-4