High-affinity recognition of the human C-reactive protein independent of phosphocholine.

Yang J, Gustavsson AL, Haraldsson M, Karlsson G, Norberg T, Baltzer L

Org. Biomol. Chem. 15 (21) 4644-4654 [2017-05-31; online 2017-05-18]

A high-affinity polypeptide conjugate 4-C25L22-DQ, has been developed for the molecular recognition of the human C-reactive protein, CRP, a well-known inflammation biomarker. CRP is one of the most frequently quantified targets in diagnostic applications and a target in drug development. With the exception of antibodies, most molecular constructs take advantage of the known affinity for CRP of phosphocholine that depends on Ca

Affiliated researcher

PubMed 28513744

DOI 10.1039/c7ob00684e

Crossref 10.1039/c7ob00684e

Publications 9.5.0