Howard RJ

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Family name Howard
Given name Rebecca J
Initials RJ
ORCID

ORCID 0000-0003-2049-3378
Affiliations SciLifeLab, Department of Biochemistry and Biophysics, Stockholm University, 17121, Solna, Sweden.

68 publications

PubMed DOI Crossref
Modeling cryo-EM structures in alternative states with AlphaFold2-based models and density-guided simulations.
Shugaeva T, Howard RJ, Haloi N, Lindahl E
Commun Chem 8 (1) 317 [2025-10-30; online 2025-10-30]
PubMed DOI Crossref
Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs.
Fan C, Cowgill J, Howard RJ, Lindahl E
Nat Commun 16 (1) 7077 [2025-08-01; online 2025-08-01]
PubMed DOI Crossref
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel.
Karlsson E, Andén O, Fan C, ..., Delarue M, Lindahl E
Br J Pharmacol 182 (12) 2790-2802 [2025-06-00; online 2025-03-11]
PubMed DOI Crossref
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization.
Abramsson ML, Corey RA, Skerle JL, ..., Stansfeld PJ, Landreh M
Elife 14 (-) - [2025-04-30; online 2025-04-30]
DOI Crossref
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Abramsson ML, Corey RA, Skerle JL, ..., Stansfeld PJ, Landreh M
Elife 14 (-) - [2025-04-30; online 2025-04-30]
PubMed DOI Crossref
Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor.
Haloi N, Karlsson E, Delarue M, Howard RJ, Lindahl E
Sci Adv 11 (15) eadr0797 [2025-04-11; online 2025-04-11]
DOI Crossref
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M
- - (-) - [2025-03-26; online 2025-03-26]
DOI Crossref
Author response: Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M
- - (-) - [2025-03-26; online 2025-03-26]
DOI Crossref
Structure and dynamics of a multidomain ligand-gated ion channel revealed under acidic conditions
Andén O, Rovšnik U, Lycksell M, ..., Howard RJ, Lindahl E
- - (-) - [2025-02-27; online 2025-02-27]
DOI Crossref
Calcium stabilization of a flexible N-terminal domain in a pentameric ligand-gated ion channel
Fan C, Lycksell M, Zhuang Y, Howard RJ, Lindahl E
- - (-) - [2025-02-27; online 2025-02-27]
DOI Crossref
Cryo-EM ligand building using generative AI and molecular dynamics
Haloi N, Howard RJ, Lindahl E
- - (-) - [2025-02-12; online 2025-02-12]
DOI Crossref
Modeling cryo-EM structures in alternative states with generative AI and density-guided simulations
Shugaeva T, Howard RJ, Haloi N, Lindahl E
- - (-) - [2025-02-08; online 2025-02-08]
DOI Crossref
Author response: Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M
- - (-) - [2025-01-16; online 2025-01-16]
DOI Crossref
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M
- - (-) - [2025-01-16; online 2025-01-16]
PubMed DOI Crossref
Adaptive sampling-based structural prediction reveals opening of a GABAA receptor through the αβ interface.
Haloi N, Eriksson Lidbrink S, Howard RJ, Lindahl E
Sci Adv 11 (2) eadq3788 [2025-01-10; online 2025-01-08]
PubMed DOI Crossref
Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors.
Zhuang Y, Howard RJ, Lindahl E
Nat Commun 15 (1) 9022 [2024-10-18; online 2024-10-18]
DOI Crossref
Resolving the conformational ensemble of a membrane protein by integrating small-angle scattering with AlphaFold
Lidbrink SE, Howard R, Haloi N, Lindahl E
- - (-) - [2024-09-07; online 2024-09-07]
PubMed DOI Crossref
Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor.
Fan C, Cowgill J, Howard RJ, Lindahl E
Nat Commun 15 (1) 7795 [2024-09-06; online 2024-09-06]
DOI Crossref
MDverse, shedding light on the dark matter of molecular dynamics simulations
Tiemann JK, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P
Elife 12 (-) - [2024-08-30; online 2024-08-30]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
MDverse, shedding light on the dark matter of molecular dynamics simulations.
Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P
Elife 12 (-) - [2024-08-30; online 2024-08-30]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore.
Gao X, Yeh HI, Yang Z, ..., Kappes JC, Hwang TC
Nat Commun 15 (1) 6668 [2024-08-06; online 2024-08-06]
DOI Crossref
Cryo-EM structures of ρ1 GABA A receptors with antagonist and agonist drugs
Fan C, Cowgill J, Howard RJ, Lindahl E
- - (-) - [2024-07-30; online 2024-07-30]
DOI Crossref
MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations
Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P
- - (-) - [2024-07-01; online 2024-07-01]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
Author response: MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations
Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P
- - (-) - [2024-07-01; online 2024-07-01]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Functional and structural insights into activation of TRPV2 by weak acids.
Haug FM, Pumroy RA, Sridhar A, ..., Moiseenkova-Bell V, Leffler A
EMBO J. 43 (11) 2264-2290 [2024-06-00; online 2024-04-26]
DOI Crossref
Adaptive sampling-based structural prediction reveals opening of a GABA receptor through the αβ interface
Haloi N, Howard RJ, Lindahl E
- - (-) - [2024-05-05; online 2024-05-05]
PubMed DOI Crossref
MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations.
Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P
bioRxiv - (-) - [2024-05-03; online 2024-05-03]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor
Lindahl E, Fan C, Cowgill J, Howard R
- - (-) - [2024-04-19; online 2024-04-19]
DOI Crossref
An Allosteric Cholesterol Site in Glycine Receptors Characterized Through Molecular Simulations
Jalalypour F, Howard RJ, Lindahl E
- - (-) - [2024-03-06; online 2024-03-06]
DOI Crossref
Divergent mechanisms of steroid inhibition in the human ρ1 GABA A receptor
Fan C, Cowgill J, Howard RJ, Lindahl E
- - (-) - [2024-01-26; online 2024-01-26]
PubMed DOI Crossref
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids.
Haloi N, Huang S, Nichols AL, ..., Mayo SL, Lester HA
bioRxiv - (-) - [2024-01-18; online 2024-01-18]
DOI Crossref
Author Response: Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Bergh C, Rovšnik U, Howard RJ, Lindahl E
- - (-) - [2024-01-05; online 2024-01-05]
DOI Crossref
Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Bergh C, Rovšnik U, Howard RJ, Lindahl E
- - (-) - [2024-01-05; online 2024-01-05]
DOI Crossref
Symmetry-adapted Markov state models of closing, opening, and desensitizing in α7 nicotinic acetylcholine receptors
Zhuang Y, Howard RJ, Lindahl E
- - (-) - [2023-12-05; online 2023-12-05]
DOI Crossref
Constant-pH Molecular Dynamics Simulations of Closed and Open States of a Proton-gated Ion Channel
Jansen A, Bauer P, Howard RJ, Hess B, Lindahl E
- - (-) - [2023-12-01; online 2023-12-01]
DOI Crossref
Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT 3 A receptor
Haloi N, Karlsson E, Delarue M, Howard RJ, Lindahl E
- - (-) - [2023-11-14; online 2023-11-14]
DOI Crossref
MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations
Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P
- - (-) - [2023-09-20; online 2023-09-20]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Structural insights into opposing actions of neurosteroids on GABAA receptors.
Legesse DH, Fan C, Teng J, ..., Lindahl E, Hibbs RE
Nat Commun 14 (1) 5091 [2023-08-22; online 2023-08-22]
DOI Crossref
Structure and dynamics of differential ligand binding in the human ρ-type GABA A receptor
Cowgill J, Fan C, Haloi N, ..., Howard RJ, Lindahl E
- - (-) - [2023-06-17; online 2023-06-17]
DOI Crossref
Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Bergh C, Rovšnik U, Howard RJ, Lindahl E
- - (-) - [2023-04-25; online 2023-04-25]
PubMed DOI Crossref
An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb.
Choudhury K, Howard RJ, Delemotte L
J. Gen. Physiol. 155 (2) - [2023-02-06; online 2022-12-14]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Bergh C, Rovšnik U, Howard RJ, Lindahl E
- - (-) - [2023-01-06; online 2023-01-06]
PubMed DOI Crossref
Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel.
Lycksell M, Rovšnik U, Hanke A, ..., Howard RJ, Lindahl E
Proc. Natl. Acad. Sci. U.S.A. 119 (50) e2210669119 [2022-12-13; online 2022-12-08]
DOI Crossref
Automated simulation-based membrane-protein refinement into cryo-EM data
Yvonnesdotter L, Rovšnik U, Blau C, ..., Howard RJ, Lindahl E
- - (-) - [2022-10-31; online 2022-10-31]
PubMed DOI Crossref
Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators.
Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E
Proc. Natl. Acad. Sci. U.S.A. 119 (43) e2208081119 [2022-10-25; online 2022-10-17]
PubMed DOI Crossref
Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.
Mehregan A, Pérez-Conesa S, Zhuang Y, ..., Ulens C, Delemotte L
Biochim Biophys Acta Biomembr 1864 (10) 183994 [2022-10-01; online 2022-06-18]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities.
Zhu S, Sridhar A, Teng J, ..., Lindahl E, Hibbs RE
Nat Commun 13 (1) 4582 [2022-08-06; online 2022-08-06]
DOI Crossref
An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb
Choudhury K, Howard RJ, Delemotte L
- - (-) - [2022-06-22; online 2022-06-22]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel
Lycksell M, Rovšnik U, Hanke A, ..., Howard RJ, Lindahl E
- - (-) - [2022-05-06; online 2022-05-06]
DOI Crossref
Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators
Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E
- - (-) - [2022-04-08; online 2022-04-08]
PubMed DOI Crossref
An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine.
Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L
Biophys. J. 121 (1) 11-22 [2022-01-04; online 2021-12-08]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
A missense mutation converts the Na+,K+-ATPase into an ion channel and causes therapy-resistant epilepsy.
Ygberg S, Akkuratov EE, Howard RJ, ..., Brismar H, Aperia A
J Biol Chem 297 (6) 101355 [2021-12-00; online 2021-10-28]
PubMed DOI Crossref
Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.
Lycksell M, Rovšnik U, Bergh C, ..., Howard RJ, Lindahl E
Proc. Natl. Acad. Sci. U.S.A. 118 (37) - [2021-09-14; online 2021-09-11]
PubMed DOI Crossref
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.
Rovšnik U, Zhuang Y, Forsberg BO, ..., Howard RJ, Lindahl E
Life Sci. Alliance 4 (8) - [2021-08-00; online 2021-07-01]
Björn Forsberg DDLS Fellow
DOI Crossref
An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing Asparagine
Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L
- - (-) - [2021-07-28; online 2021-07-28]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium
Mehregan A, Pérez-Conesa S, Zhuang Y, ..., Ulens C, Delemotte L
- - (-) - [2021-05-28; online 2021-05-28]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering
Lycksell M, Rovšnik U, Bergh C, ..., Howard RJ, Lindahl E
- - (-) - [2021-04-11; online 2021-04-11]
DOI Crossref
A cationic lipid site at the outward transmembrane face of a pentameric ligand-gated ion channel
Sridhar A, Lummis SCR, Pasini D, ..., Howard RJ, Ulens C
- - (-) - [2021-03-25; online 2021-03-25]
DOI Crossref
Markov State Models of Proton- and Gate-Dependent Activation in a Pentameric Ligand-Gated Ion Channel
Bergh C, Heusser SA, Howard RJ, Lindahl E
- - (-) - [2021-03-12; online 2021-03-12]
PubMed DOI Crossref
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.
Alekseenko A, Barrett D, Pareja-Sanchez Y, ..., Yin X, Pelechano V
Sci Rep 11 (1) 1820 [2021-01-19; online 2021-01-19]
SciLifeLab Fellow Simon Elsässer
DOI Crossref
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
Rovšnik U, Zhuang Y, Forsberg BO, ..., Howard RJ, Lindahl E
- - (-) - [2021-01-05; online 2021-01-05]
Björn Forsberg DDLS Fellow
PubMed DOI Crossref
Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex.
Forsberg BO, Aibara S, Howard RJ, Mortezaei N, Lindahl E
Nat Commun 11 (1) 4667 [2020-09-16; online 2020-09-16]
Björn Forsberg DDLS Fellow
PubMed DOI Crossref
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Kim JJ, Gharpure A, Teng J, ..., Lindahl E, Hibbs RE
Nature 585 (7824) 303-308 [2020-09-00; online 2020-09-02]
DOI Crossref
Assembly and symmetry of the fungal E3BP-containing core of the Pyruvate Dehydrogenase Complex
Forsberg BO, Aibara S, Howard RJ, Mortezaei N, Lindahl E
- - (-) - [2020-08-14; online 2020-08-14]
Björn Forsberg DDLS Fellow
DOI Crossref
Characterization of the dynamic resting state of a pentameric ligand-gated ion channel by cryo-electron microscopy and simulations
Rovšnik U, Zhuang Y, Axelsson L, ..., Howard R, Lindahl E
- - (-) - [2020-06-20; online 2020-06-20]
Björn Forsberg DDLS Fellow
PubMed DOI Crossref
Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel.
Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M
Proc. Natl. Acad. Sci. U.S.A. 117 (24) 13437-13446 [2020-06-16; online 2020-06-01]
DOI Crossref
Defective membrane insertion of mutant Na,K‐ATPase, a cause of fatal epilepsy
Howard R, Ygberg S, Andersson M, ..., Lindstrand A, Aperia A
The FASEB Journal 34 (S1) 1-1 [2020-04-00; online 2020-04-18]
PubMed DOI Crossref
Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.
Heusser SA, Yoluk Ö, Klement G, ..., Lindahl E, Howard RJ
J. Neurochem. 138 (2) 243-253 [2016-07-00; online 2016-05-25]
SciLifeLab Data Centre
Publications 9.5.1