Howard RJ

Modeling cryo-EM structures in alternative states with AlphaFold2-based models and density-guided simulations.

Shugaeva T, Howard RJ, Haloi N, Lindahl E

Commun Chem 8 (1) 317 [2025-10-30; online 2025-10-30]

Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs.

Fan C, Cowgill J, Howard RJ, Lindahl E

Nat Commun 16 (1) 7077 [2025-08-01; online 2025-08-01]

Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel.

Karlsson E, Andén O, Fan C, ..., Delarue M, Lindahl E

Br J Pharmacol 182 (12) 2790-2802 [2025-06-00; online 2025-03-11]

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization.

Abramsson ML, Corey RA, Skerle JL, ..., Stansfeld PJ, Landreh M

Elife 14 (-) - [2025-04-30; online 2025-04-30]

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Abramsson ML, Corey RA, Skerle JL, ..., Stansfeld PJ, Landreh M

Elife 14 (-) - [2025-04-30; online 2025-04-30]

Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor.

Haloi N, Karlsson E, Delarue M, Howard RJ, Lindahl E

Sci Adv 11 (15) eadr0797 [2025-04-11; online 2025-04-11]

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M

- - (-) - [2025-03-26; online 2025-03-26]

Author response: Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M

- - (-) - [2025-03-26; online 2025-03-26]

Structure and dynamics of a multidomain ligand-gated ion channel revealed under acidic conditions

Andén O, Rovšnik U, Lycksell M, ..., Howard RJ, Lindahl E

- - (-) - [2025-02-27; online 2025-02-27]

Calcium stabilization of a flexible N-terminal domain in a pentameric ligand-gated ion channel

Fan C, Lycksell M, Zhuang Y, Howard RJ, Lindahl E

- - (-) - [2025-02-27; online 2025-02-27]

Cryo-EM ligand building using generative AI and molecular dynamics

Haloi N, Howard RJ, Lindahl E

- - (-) - [2025-02-12; online 2025-02-12]

Modeling cryo-EM structures in alternative states with generative AI and density-guided simulations

Shugaeva T, Howard RJ, Haloi N, Lindahl E

- - (-) - [2025-02-08; online 2025-02-08]

Author response: Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M

- - (-) - [2025-01-16; online 2025-01-16]

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Abramsson ML, Corey RA, Škerle J, ..., Stansfeld PJ, Landreh M

- - (-) - [2025-01-16; online 2025-01-16]

Adaptive sampling-based structural prediction reveals opening of a GABAA receptor through the αβ interface.

Haloi N, Eriksson Lidbrink S, Howard RJ, Lindahl E

Sci Adv 11 (2) eadq3788 [2025-01-10; online 2025-01-08]

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors.

Zhuang Y, Howard RJ, Lindahl E

Nat Commun 15 (1) 9022 [2024-10-18; online 2024-10-18]

Resolving the conformational ensemble of a membrane protein by integrating small-angle scattering with AlphaFold

Lidbrink SE, Howard R, Haloi N, Lindahl E

- - (-) - [2024-09-07; online 2024-09-07]

Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor.

Fan C, Cowgill J, Howard RJ, Lindahl E

Nat Commun 15 (1) 7795 [2024-09-06; online 2024-09-06]

MDverse, shedding light on the dark matter of molecular dynamics simulations

Tiemann JK, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P

Elife 12 (-) - [2024-08-30; online 2024-08-30]

MDverse, shedding light on the dark matter of molecular dynamics simulations.

Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P

Elife 12 (-) - [2024-08-30; online 2024-08-30]

Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore.

Gao X, Yeh HI, Yang Z, ..., Kappes JC, Hwang TC

Nat Commun 15 (1) 6668 [2024-08-06; online 2024-08-06]

Cryo-EM structures of ρ1 GABA A receptors with antagonist and agonist drugs

Fan C, Cowgill J, Howard RJ, Lindahl E

- - (-) - [2024-07-30; online 2024-07-30]

MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations

Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P

- - (-) - [2024-07-01; online 2024-07-01]

Author response: MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations

Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P

- - (-) - [2024-07-01; online 2024-07-01]

Functional and structural insights into activation of TRPV2 by weak acids.

Haug FM, Pumroy RA, Sridhar A, ..., Moiseenkova-Bell V, Leffler A

EMBO J. 43 (11) 2264-2290 [2024-06-00; online 2024-04-26]

Adaptive sampling-based structural prediction reveals opening of a GABA receptor through the αβ interface

Haloi N, Howard RJ, Lindahl E

- - (-) - [2024-05-05; online 2024-05-05]

MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations.

Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P

bioRxiv - (-) - [2024-05-03; online 2024-05-03]

Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor

Lindahl E, Fan C, Cowgill J, Howard R

- - (-) - [2024-04-19; online 2024-04-19]

An Allosteric Cholesterol Site in Glycine Receptors Characterized Through Molecular Simulations

Jalalypour F, Howard RJ, Lindahl E

- - (-) - [2024-03-06; online 2024-03-06]

Divergent mechanisms of steroid inhibition in the human ρ1 GABA A receptor

Fan C, Cowgill J, Howard RJ, Lindahl E

- - (-) - [2024-01-26; online 2024-01-26]

Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids.

Haloi N, Huang S, Nichols AL, ..., Mayo SL, Lester HA

bioRxiv - (-) - [2024-01-18; online 2024-01-18]

Author Response: Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

- - (-) - [2024-01-05; online 2024-01-05]

Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

- - (-) - [2024-01-05; online 2024-01-05]

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α7 nicotinic acetylcholine receptors

Zhuang Y, Howard RJ, Lindahl E

- - (-) - [2023-12-05; online 2023-12-05]

Constant-pH Molecular Dynamics Simulations of Closed and Open States of a Proton-gated Ion Channel

Jansen A, Bauer P, Howard RJ, Hess B, Lindahl E

- - (-) - [2023-12-01; online 2023-12-01]

Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT 3 A receptor

Haloi N, Karlsson E, Delarue M, Howard RJ, Lindahl E

- - (-) - [2023-11-14; online 2023-11-14]

MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations

Tiemann JKS, Szczuka M, Bouarroudj L, ..., Chavent M, Poulain P

- - (-) - [2023-09-20; online 2023-09-20]

Structural insights into opposing actions of neurosteroids on GABAA receptors.

Legesse DH, Fan C, Teng J, ..., Lindahl E, Hibbs RE

Nat Commun 14 (1) 5091 [2023-08-22; online 2023-08-22]

Structure and dynamics of differential ligand binding in the human ρ-type GABA A receptor

Cowgill J, Fan C, Haloi N, ..., Howard RJ, Lindahl E

- - (-) - [2023-06-17; online 2023-06-17]

Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

- - (-) - [2023-04-25; online 2023-04-25]

An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb.

Choudhury K, Howard RJ, Delemotte L

J. Gen. Physiol. 155 (2) - [2023-02-06; online 2022-12-14]

Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

- - (-) - [2023-01-06; online 2023-01-06]

Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel.

Lycksell M, Rovšnik U, Hanke A, ..., Howard RJ, Lindahl E

Proc. Natl. Acad. Sci. U.S.A. 119 (50) e2210669119 [2022-12-13; online 2022-12-08]

Automated simulation-based membrane-protein refinement into cryo-EM data

Yvonnesdotter L, Rovšnik U, Blau C, ..., Howard RJ, Lindahl E

- - (-) - [2022-10-31; online 2022-10-31]

Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators.

Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E

Proc. Natl. Acad. Sci. U.S.A. 119 (43) e2208081119 [2022-10-25; online 2022-10-17]

Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.

Mehregan A, Pérez-Conesa S, Zhuang Y, ..., Ulens C, Delemotte L

Biochim Biophys Acta Biomembr 1864 (10) 183994 [2022-10-01; online 2022-06-18]

Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities.

Zhu S, Sridhar A, Teng J, ..., Lindahl E, Hibbs RE

Nat Commun 13 (1) 4582 [2022-08-06; online 2022-08-06]

An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb

Choudhury K, Howard RJ, Delemotte L

- - (-) - [2022-06-22; online 2022-06-22]

Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel

Lycksell M, Rovšnik U, Hanke A, ..., Howard RJ, Lindahl E

- - (-) - [2022-05-06; online 2022-05-06]

Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators

Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E

- - (-) - [2022-04-08; online 2022-04-08]

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine.

Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L

Biophys. J. 121 (1) 11-22 [2022-01-04; online 2021-12-08]

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.

Lycksell M, Rovšnik U, Bergh C, ..., Howard RJ, Lindahl E

Proc. Natl. Acad. Sci. U.S.A. 118 (37) - [2021-09-14; online 2021-09-11]

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.

Rovšnik U, Zhuang Y, Forsberg BO, ..., Howard RJ, Lindahl E

Life Sci. Alliance 4 (8) - [2021-08-00; online 2021-07-01]

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing Asparagine

Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L

- - (-) - [2021-07-28; online 2021-07-28]

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering

Lycksell M, Rovšnik U, Bergh C, ..., Howard RJ, Lindahl E

- - (-) - [2021-04-11; online 2021-04-11]

A cationic lipid site at the outward transmembrane face of a pentameric ligand-gated ion channel

Sridhar A, Lummis SCR, Pasini D, ..., Howard RJ, Ulens C

- - (-) - [2021-03-25; online 2021-03-25]

Markov State Models of Proton- and Gate-Dependent Activation in a Pentameric Ligand-Gated Ion Channel

Bergh C, Heusser SA, Howard RJ, Lindahl E

- - (-) - [2021-03-12; online 2021-03-12]

Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.

Alekseenko A, Barrett D, Pareja-Sanchez Y, ..., Yin X, Pelechano V

Sci Rep 11 (1) 1820 [2021-01-19; online 2021-01-19]

SciLifeLab Fellow Simon Elsässer Vicent Pelechano

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

Rovšnik U, Zhuang Y, Forsberg BO, ..., Howard RJ, Lindahl E

- - (-) - [2021-01-05; online 2021-01-05]

Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex.

Forsberg BO, Aibara S, Howard RJ, Mortezaei N, Lindahl E

Nat Commun 11 (1) 4667 [2020-09-16; online 2020-09-16]

Shared structural mechanisms of general anaesthetics and benzodiazepines.

Kim JJ, Gharpure A, Teng J, ..., Lindahl E, Hibbs RE

Nature 585 (7824) 303-308 [2020-09-00; online 2020-09-02]

Assembly and symmetry of the fungal E3BP-containing core of the Pyruvate Dehydrogenase Complex

Forsberg BO, Aibara S, Howard RJ, Mortezaei N, Lindahl E

- - (-) - [2020-08-14; online 2020-08-14]

Characterization of the dynamic resting state of a pentameric ligand-gated ion channel by cryo-electron microscopy and simulations

Rovšnik U, Zhuang Y, Axelsson L, ..., Howard R, Lindahl E

- - (-) - [2020-06-20; online 2020-06-20]