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Afrasiabi R, Soderberg LM, Joensson HN, Björk P, Andersson Svahn H, Linnros J
Micromachines (Basel) 7 (8) - [2016-08-05; online 2016-08-05]
We present a novel microfluidic system that integrates droplet microfluidics with a silicon nanoribbon field-effect transistor (SiNR FET), and utilize this integrated system to sense differences in pH. The device allows for selective droplet transfer to a continuous water phase, actuated by dielectrophoresis, and subsequent detection of the pH level in the retrieved droplets by SiNR FETs on an electrical sensor chip. The integrated microfluidic system demonstrates a label-free detection method for droplet microfluidics, presenting an alternative to optical fluorescence detection. In this work, we were able to differentiate between droplet trains of one pH-unit difference. The pH-based detection method in our integrated system has the potential to be utilized in the detection of biochemical reactions that induce a pH-shift in the droplets.
PubMed 30404306
DOI 10.3390/mi7080134
Crossref 10.3390/mi7080134
pii: mi7080134
pmc: PMC6190078