HieranoiDB: a database of orthologs inferred by Hieranoid.

Kaduk M, Riegler C, Lemp O, Sonnhammer EL

Nucleic Acids Res. 45 (D1) D687-D690 [2017-01-04; online 2016-10-13]

HieranoiDB (http://hieranoiDB.sbc.su.se) is a freely available on-line database for hierarchical groups of orthologs inferred by the Hieranoid algorithm. It infers orthologs at each node in a species guide tree with the InParanoid algorithm as it progresses from the leaves to the root. Here we present a database HieranoiDB with a web interface that makes it easy to search and visualize the output of Hieranoid, and to download it in various formats. Searching can be performed using protein description, identifier or sequence. In this first version, orthologs are available for the 66 Quest for Orthologs reference proteomes. The ortholog trees are shown graphically and interactively with marked speciation and duplication nodes that show the inferred evolutionary scenario, and allow for correct extraction of predicted orthologs from the Hieranoid trees.

Affiliated researcher

PubMed 27742821

DOI 10.1093/nar/gkw923

Crossref 10.1093/nar/gkw923

pii: gkw923
pmc: PMC5210627

Publications 9.5.0