Loksha YM, Globisch D, Pedersen EB, La Colla P, Collu G, Loddo R
J. Heterocyclic Chem. 45 (-) 1161-1166 [2009-03-13; online 2009-03-13]
1,5‐Disubstituted pyrimidine‐2,4‐diones were synthesized by fusion of 5‐bromouracil with an aniline derivative followed by coupling with benzyl halide whereas the opposite synthesis sequence failed. Also 4,6‐dichloro‐N,N,5‐trimethylpyrimidin‐2‐amine was treated with phenols. The products were tested for their activity against HIV‐1.