Aleksej Zelezniak

Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells.

Saghaleyni R, Malm M, Moruzzi N, ..., Robinson JL, Rockberg J

Cell Reports 39 (11) 110936 [2022-06-14; online 2022-06-16]

Aleksej Zelezniak DDLS Fellow Fredrik Edfors SciLifeLab Fellow

Data mining of Saccharomyces cerevisiae mutants engineered for increased tolerance towards inhibitors in lignocellulosic hydrolysates.

Cámara E, Olsson L, Zrimec J, ..., Geijer C, Nygård Y

Biotechnol Adv 57 (-) 107947 [2022-03-18; online 2022-03-18]

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

Correia-Melo C, Kamrad S, Messner CB, ..., Papp B, Ralser M

- - (-) - [2022-03-07; online 2022-03-07]

Year 2021

Potential for improved retention rate by personalized antiseizure medication selection: A register-based analysis.

Håkansson S, Karlander M, Larsson D, ..., Zelezniak A, Zelano J

Epilepsia 62 (9) 2123-2132 [2021-09-00; online 2021-07-09]

Learning the Regulatory Code of Gene Expression.

Zrimec J, Buric F, Kokina M, Garcia V, Zelezniak A

Front Mol Biosci 8 (-) 673363 [2021-06-10; online 2021-06-10]

Expanding functional protein sequence spaces using generative adversarial networks

Repecka D, Jauniskis V, Karpus L, ..., Engqvist MKM, Zelezniak A

Nat Mach Intell 3 (4) 324-333 [2021-03-04; online 2021-03-04]

Bayesian genome scale modelling identifies thermal determinants of yeast metabolism.

Li G, Hu Y, Luo H, ..., Ji B, Nielsen J

Nat Commun 12 (1) 190 [2021-01-08; online 2021-01-08]

Year 2020

Plastic-degrading potential across the global microbiome correlates with recent pollution trends

Zrimec J, Kokina M, Jonasson S, Zorrilla F, Zelezniak A

- - (-) - [2020-12-13; online 2020-12-13]

Parallel Factor Analysis Enables Quantification and Identification of Highly Convolved Data-Independent-Acquired Protein Spectra.

Buric F, Zrimec J, Zelezniak A

Patterns (N Y) 1 (9) 100137 [2020-12-11; online 2020-11-05]

Transcriptome analysis of EPO and GFP HEK293 Cell-lines Reveal Shifts in Energy and ER Capacity Support Improved Erythropoietin Production in HEK293F Cells

Saghaleyni R, Malm M, Zrimec J, ..., Robinson JL, Rockberg J

- - (-) - [2020-09-16; online 2020-09-16]

Parallel factor analysis enables quantification and identification of highly-convolved data independent-acquired protein spectra

Buric F, Zrimec J, Zelezniak A

- - (-) - [2020-04-23; online 2020-04-23]

Bayesian genome scale modelling identifies thermal determinants of yeast metabolism

Li G, Hu Y, Wang H, ..., Zrimec J, Nielsen J

- - (-) - [2020-04-02; online 2020-04-02]

Year 2019

Gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

Zrimec J, Buric F, Muhammad AS, ..., Töpel M, Zelezniak A

- - (-) - [2019-10-04; online 2019-10-04]

Expanding functional protein sequence space using generative adversarial networks

Repecka D, Jauniskis V, Karpus L, ..., Engqvist MKM, Zelezniak A

- - (-) - [2019-10-02; online 2019-10-02]

Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.

Gossmann TI, Shanmugasundram A, Börno S, ..., Timmermann B, Ralser M

Curr. Biol. 29 (10) 1712-1720.e7 [2019-05-20; online 2019-05-09]

Year 2018

Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies.

Tramontano M, Andrejev S, Pruteanu M, ..., Typas A, Patil KR

Nat. Microbiol 3 (4) 514-522 [2018-04-00; online 2018-03-19]

Biochemical principles enabling metabolic cooperativity and phenotypic heterogeneity at the single cell level

Campbell K, Herrera-Dominguez L, Correia-Melo C, Zelezniak A, Ralser M

Current Opinion in Systems Biology 8 (-) 97-108 [2018-04-00; online 2018-04-00]

Year 2017

The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization.

Alam MT, Olin-Sandoval V, Stincone A, ..., Luisi BF, Ralser M

Nat Commun 8 (-) 16018 [2017-07-10; online 2017-07-10]

Year 2016

Functional Metabolomics Describes the Yeast Biosynthetic Regulome

Mülleder M, Calvani E, Alam MT, ..., Zelezniak A, Ralser M

Cell 167 (2) 553-565.e12 [2016-10-00; online 2016-10-00]

The metabolic background is a global player in Saccharomyces gene expression epistasis

Alam MT, Zelezniak A, Mülleder M, ..., Lilley KS, Ralser M

Nat. Microbiol 1 (3) 15030 [2016-02-01; online 2016-02-01]

Year 2015

Metabolic dependencies drive species co-occurrence in diverse microbial communities

Zelezniak A, Andrejev S, Ponomarova O, ..., Bork P, Patil KR

Proceedings of the National Academy of Sciences 112 (20) 6449-6454 [2015-05-19; online 2015-05-04]

Year 2014

Contribution of Network Connectivity in Determining the Relationship between Gene Expression and Metabolite Concentration Changes

Zelezniak A, Sheridan S, Patil KR

PLoS Comput Biol 10 (4) e1003572 [2014-04-24; online 2014-04-24]

Year 2012

Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours

Yamada T, Waller AS, Raes J, ..., Weissenbach J, Bork P

Mol Syst Biol 8 (-) - [2012-05-08; online 2012-05-08]

Year 2011

Flux coupling and transcriptional regulation within the metabolic network of the photosynthetic bacterium Synechocystis sp. PCC6803

Montagud A, Zelezniak A, Navarro E, ..., Urchueguía JF, Patil KR

Biotechnology Journal 6 (3) 330-342 [2011-03-00; online 2011-01-11]

Year 2010

Metabolic Network Topology Reveals Transcriptional Regulatory Signatures of Type 2 Diabetes

Zelezniak A, Pers TH, Soares S, Patti ME, Patil KR

PLoS Comput Biol 6 (4) e1000729 [2010-04-01; online 2010-04-01]