Total biosynthesis of the cyclic AMP booster forskolin from

Pateraki I, Andersen-Ranberg J, Jensen NB, Wubshet SG, Heskes AM, Forman V, Hallström B, Hamberger B, Motawia MS, Olsen CE, Staerk D, Hansen J, Møller BL, Hamberger B

Elife 6 (-) - [2017-03-14; online 2017-03-14]

Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant

Affiliated researcher

PubMed 28290983

DOI 10.7554/eLife.23001

Crossref 10.7554/eLife.23001

pmc: PMC5388535

Publications 9.5.0