Bartek J

Family name	Bartek
Given name	Jiri
Initials	J
ORCID	ORCID 0000-0003-2013-7525
Affiliations	Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden. mikael.lindstrom@ki.se jb@cancer.dk. Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.

30 publications

PubMed DOI Crossref

Does human cytomegalovirus provide a novel therapeutic target for patients with glioblastoma?

Söderberg-Naucler C, Pantalone MR, Stragliotto G, Bartek J

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 380 (1938) 20240403 [2025-11-06; online 2025-11-06]

PubMed DOI Crossref

SF3B1-mutant models of RNA mis-splicing uncover UBA1 as a therapeutic target in myelodysplastic neoplasms.

Thier J, Hofmann S, Kirchhof KM, ..., Moura PL, Lundin V

Leukemia 39 (11) 2801-2811 [2025-11-00; online 2025-08-26]

PubMed DOI Crossref

The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis.

Cianfanelli V, Nanni M, Corrà S, ..., Ziviani E, Cecconi F

Sci Adv 11 (40) eadw7376 [2025-10-03; online 2025-10-03]

PubMed DOI Crossref

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence.

Liblova Z, Maurencova D, Salovska B, ..., Vajrychova M, Hodny Z

Mol Oncol 19 (9) 2619-2647 [2025-09-00; online 2025-04-27]

Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures

Hawgood M, Urién González B, Agostinho A, ..., Blom H, Lemmens B

- - (-) - [2025-02-23; online 2025-02-23]

PubMed DOI Crossref

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.

Lu WT, Zalmas LP, Bailey C, ..., Kanu N, Swanton C

Nat. Cell Biol. 27 (1) 154-168 [2025-01-00; online 2024-12-30]

PubMed DOI Crossref

Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation.

Gál Z, Boukoura S, Oxe KC, ..., Luo Y, Larsen DH

Nat Commun 15 (1) 7797 [2024-09-06; online 2024-09-06]

PubMed DOI Crossref

Exploring the structural landscape of DNA maintenance proteins.

Schou KB, Mandacaru S, Tahir M, ..., Papaleo E, Bartek J

Nat Commun 15 (1) 7748 [2024-09-05; online 2024-09-05]

Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy

Wang J, Strauss R, Bartek J, Rudd SG

- - (-) - [2024-07-22; online 2024-07-22]

PubMed DOI Crossref

Chromatin damage generated by DNA intercalators leads to degradation of RNA Polymerase II.

Espinoza JA, Kanellis DC, Saproo S, ..., Bartek J, Lindström MS

Nucleic Acids Res. 52 (8) 4151-4166 [2024-05-08; online 2024-02-10]

PubMed DOI Crossref

The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia.

Miliara S, Cozzi E, Zhong X, ..., Bartek J, Kanellis DC

Leukemia 38 (3) 663-666 [2024-03-00; online 2023-11-30]

PubMed DOI Crossref

NAD+ regulates nucleotide metabolism and genomic DNA replication.

Munk SHN, Merchut-Maya JM, Adelantado Rubio A, ..., Bartek J, Maya-Mendoza A

Nat. Cell Biol. 25 (12) 1774-1786 [2023-12-00; online 2023-11-13]

RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instability

Checa-Rodríguez C, Suárez-Quintero B, Contreras L, ..., Bartek J, Gómez-Cabello D

- - (-) - [2023-10-22; online 2023-10-22]

PubMed DOI Crossref

Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway.

Maynard S, Hall A, Galanos P, ..., Maya-Mendoza A, Bartek J

Nucleic Acids Res. 50 (17) 9948-9965 [2022-09-23; online 2022-09-14]

PubMed DOI Crossref

CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway.

Gómez-Cabello D, Pappas G, Aguilar-Morante D, Dinant C, Bartek J

Nat Commun 13 (1) 5303 [2022-09-09; online 2022-09-09]

PubMed DOI Crossref

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways.

Lindström MS, Bartek J, Maya-Mendoza A

Cell Death Differ. 29 (5) 972-982 [2022-05-00; online 2022-04-20]

PubMed DOI Crossref

Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress.

Larsen BD, Benada J, Yung PYK, ..., Bartek J, Sørensen CS

Science (New York, N.Y.) 376 (6592) 476-483 [2022-04-29; online 2022-04-28]

SciLifeLab Fellow Simon Elsässer

PubMed DOI Crossref

Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET.

Buchtova T, Skrott Z, Chroma K, ..., Bartek J, Mistrik M

Mol Oncol 16 (7) 1541-1554 [2022-04-00; online 2021-10-26]

PubMed DOI Crossref

A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment.

Chroma K, Skrott Z, Gursky J, ..., Mistrik M, Bartek J

Cell Death Dis 13 (3) 203 [2022-03-04; online 2022-03-04]

PubMed DOI Crossref

RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis.

Moudry P, Chroma K, Bursac S, Volarevic S, Bartek J

Cell Death Differ. 29 (3) 687-696 [2022-03-00; online 2021-10-05]

PubMed DOI Crossref

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

Krastev DB, Li S, Sun Y, ..., Ramadan K, Lord CJ

Nat. Cell Biol. 24 (1) 62-73 [2022-01-00; online 2022-01-10]

PubMed DOI Crossref

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.

Kanellis DC, Espinoza JA, Zisi A, ..., Lindström MS, Bartek J

Sci Adv 7 (32) - [2021-08-00; online 2021-08-04]

SciLifeLab Fellow Simon Elsässer

PubMed DOI Crossref

The human nucleoporin Tpr protects cells from RNA-mediated replication stress.

Kosar M, Giannattasio M, Piccini D, ..., Bartek J, Foiani M

Nat Commun 12 (1) 3937 [2021-06-24; online 2021-06-24]

PubMed DOI Crossref

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

Maiani E, Milletti G, Nazio F, ..., Bartek J, Cecconi F

Nature 592 (7856) 799-803 [2021-04-00; online 2021-04-14]

PubMed DOI Crossref

Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response.

Mistrik M, Skrott Z, Muller P, ..., Kvitek L, Bartek J

Nat Commun 12 (1) 713 [2021-01-29; online 2021-01-29]

PubMed DOI Crossref

Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes.

Pribyl M, Hubackova S, Moudra A, ..., Bartek J, Hodny Z

Mol Oncol 14 (10) 2403-2419 [2020-10-00; online 2020-08-11]

PubMed DOI Crossref

NQO1*2 polymorphism predicts overall survival in MDS patients.

Moudra A, Minarik L, Vancurova M, ..., Hodny Z, Jonasova A

Br. J. Haematol. 184 (2) 305-308 [2019-01-00; online 2018-01-24]

PubMed DOI Crossref

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Hjorth-Jensen K, Maya-Mendoza A, Dalgaard N, ..., Olsen JV, Flores-Morales A

Nucleic Acids Res. 46 (18) 9484-9495 [2018-10-12; online 2018-08-21]

PubMed DOI Crossref

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Gogola E, Duarte AA, de Ruiter JR, ..., Jonkers J, Rottenberg S

Cancer Cell 33 (6) 1078-1093.e12 [2018-06-11; online 2018-06-13]

Affiliated researcher

PubMed DOI Crossref

Daughters sense their mother's stress.

Strauss R, Bartek J

Cell Cycle 17 (2) 145-146 [2018-01-10; online 2018-01-10]

SciLifeLab Data Centre

Publications 9.5.1