Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
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Brandmayr C, Wagner M, Brückl T, Globisch D, Pearson D, Kneuttinger AC, Reiter V, Hienzsch A, Koch S, Thoma I, Thumbs P, Michalakis S, Müller M, Biel M, Carell T
Angewandte Chemie International Edition 51 (44) 11162-11165 [2012-10-29; online 2012-10-04]
Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency.
PubMed 23037940
DOI 10.1002/anie.201203769
Crossref 10.1002/anie.201203769