Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency

Brandmayr C, Wagner M, Brückl T, Globisch D, Pearson D, Kneuttinger AC, Reiter V, Hienzsch A, Koch S, Thoma I, Thumbs P, Michalakis S, Müller M, Biel M, Carell T

Angewandte Chemie International Edition 51 (44) 11162-11165 [2012-10-29; online 2012-10-04]

Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency.

Daniel Globisch

SciLifeLab Fellow

PubMed 23037940

DOI 10.1002/anie.201203769

Crossref 10.1002/anie.201203769

Publications 9.5.0