Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma.
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Burmakin M, van Wieringen T, Olsson PO, Stuhr L, Åhgren A, Heldin CH, Reed RK, Rubin K, Hellberg C
J Transl Med 15 (1) 47 [2017-02-23; online 2017-02-23]
Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. We compared the effects of imatinib on oxygen levels, vascular morphology and IFP in three experimental tumor models differing in their content of a collagenous extracellular matrix. Neither the KAT4 and CT-26 colonic carcinoma models, nor B16BB melanoma expressed PDGF β-receptors in the malignant cells. KAT-4 tumors exhibited a well-developed ECM in contrast to the other two model systems. The collagen content was substantially higher in KAT-4 than in CT-26, while collagen was not detectable in B16BB tumors. The pO Our data suggest that the effects of imatinib on pO
PubMed 28231806
DOI 10.1186/s12967-017-1142-7
Crossref 10.1186/s12967-017-1142-7
pii: 10.1186/s12967-017-1142-7
pmc: PMC5324310