LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

Pearson D, Hienzsch A, Wagner M, Globisch D, Reiter V, Özden D, Carell T

Chem. Commun. 47 (18) 5196 [2011-00-00; online 2011-00-00]

RNA nucleosides are often naturally modified into complex non-canonical structures with key biological functions. Here we report LC-MS quantification of the Ar(p) and Gr(p) 2'-ribosylated nucleosides in tRNA using deuterium labelled standards, and the first detection of Gr(p) in complex fungi.

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PubMed 21448475

DOI 10.1039/c1cc11011j

Crossref 10.1039/c1cc11011j