Improved predictions by Pcons.net using multiple templates.

Larsson P, Skwark MJ, Wallner B, Elofsson A

Bioinformatics 27 (3) 426-427 [2011-02-01; online 2010-12-11]

Multiple templates can often be used to build more accurate homology models than models built from a single template. Here we introduce PconsM, an automated protocol that uses multiple templates to build protein models. PconsM has been among the top-performing methods in the recent CASP experiments and consistently perform better than the single template models used in Pcons.net. In particular for the easier targets with many alternative templates with a high degree of sequence identity, quality is readily improved with a few percentages over the highest ranked model built on a single template. PconsM is available as an additional pipeline within the Pcons.net protein structure prediction server. PconsM is freely available from http://pcons.net/.

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PubMed 21149277

DOI 10.1093/bioinformatics/btq664

Crossref 10.1093/bioinformatics/btq664

btq664

pmc PMC3031036