Nicholas Pearce (16 publications)

DDLS Fellow: Cell and molecular biology

Primary: Shown in the list of current labels.

Year 2022

PubMed DOI Crossref

Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data.

Weiss MS, Wollenhaupt J, Correy GJ, ..., Thunissen M, Pearce NM

Protein Sci. 31 (9) e4391 [2022-09-00; online 2022-08-31]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies.

Pearce NM, Skyner R, Krojer T

Front Mol Biosci 9 (-) 861491 [2022-04-11; online 2022-04-11]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures.

Wood TM, Zeronian MR, Buijs N, ..., Janssen BJC, Martin NI

Chem Sci 13 (10) 2985-2991 [2022-03-09; online 2022-02-21]

DDLS Fellow Nicholas Pearce

Year 2021

PubMed DOI Crossref

Improving sampling of crystallographic disorder in ensemble refinement.

Ploscariu N, Burnley T, Gros P, Pearce NM

Acta Crystallogr D Struct Biol 77 (Pt 11) 1357-1364 [2021-11-01; online 2021-10-20]

DDLS Fellow Nicholas Pearce

DOI Crossref

A method for intuitively extracting macromolecular dynamics from structural disorder

Pearce NM, Gros P

Nat Commun 12 (1) - [2021-09-17; online 2021-09-17]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling.

Wendt M, Bellavita R, Gerber A, ..., Hennig S, Grossmann TN

Angew. Chem. Int. Ed. Engl. 60 (25) 13937-13944 [2021-06-14; online 2021-05-05]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source.

Douangamath A, Powell A, Fearon D, ..., Gorrie-Stone T, von Delft F

J Vis Exp - (171) - [2021-05-29; online 2021-05-29]

DDLS Fellow Nicholas Pearce

Year 2020

DOI Crossref

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

Oosterheert W, Xenaki KT, Neviani V, ..., van Bergen en Henegouwen PM, Gros P

Life Sci. Alliance 3 (11) e202000883 [2020-11-00; online 2020-09-21]

DDLS Fellow Nicholas Pearce

Year 2019

PubMed DOI Crossref

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.

van den Bos RM, Pearce NM, Granneman J, Brondijk THC, Gros P

Front Immunol 10 (-) 2097 [2019-09-04; online 2019-09-04]

DDLS Fellow Nicholas Pearce

Year 2018

PubMed DOI Crossref

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.

Keedy DA, Hill ZB, Biel JT, ..., Wells JA, Fraser JS

Elife 7 (-) - [2018-06-07; online 2018-06-07]

DDLS Fellow Nicholas Pearce

Year 2017

PubMed DOI Crossref

Ten simple rules for surviving an interdisciplinary PhD.

Demharter S, Pearce N, Beattie K, ..., Deane CM, Knapp B

PLoS Comput Biol 13 (5) e1005512 [2017-05-00; online 2017-05-25]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites.

Pearce NM, Bradley AR, Krojer T, ..., Deane CM, von Delft F

Struct Dyn 4 (3) 032104 [2017-05-00; online 2017-02-28]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.

Pearce NM, Krojer T, Bradley AR, ..., Deane CM, von Delft F

Nat Commun 8 (-) 15123 [2017-04-24; online 2017-04-24]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.

Krojer T, Talon R, Pearce N, ..., Marsden B, von Delft F

Acta Crystallogr D Struct Biol 73 (Pt 3) 267-278 [2017-03-01; online 2017-02-24]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

Proper modelling of ligand binding requires an ensemble of bound and unbound states.

Pearce NM, Krojer T, von Delft F

Acta Crystallogr D Struct Biol 73 (Pt 3) 256-266 [2017-03-01; online 2017-03-06]

DDLS Fellow Nicholas Pearce

PubMed DOI Crossref

Gentle, fast and effective crystal soaking by acoustic dispensing.

Collins PM, Ng JT, Talon R, ..., Pearce NM, von Delft F

Acta Crystallogr D Struct Biol 73 (Pt 3) 246-255 [2017-03-01; online 2017-03-06]

DDLS Fellow Nicholas Pearce