Boren J

Family name	Boren
Given name	Jan
Initials	J
ORCID	ORCID 0000-0003-0786-8091
Affiliations	Department of Molecular and Clinical Medicine, University of Gothenburg, The Wallenberg Laboratory, Sahlgrenska University Hospital, SE-41345 Gothenburg, Sweden.

20 publications

PubMed DOI Crossref

Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function.

Laudette M, Lindbom M, Arif M, ..., Levin MC, Borén J

Cardiovasc Res 119 (7) 1537-1552 [2023-07-04; online 2023-03-08]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Revisiting the role of serine metabolism in hepatic lipogenesis.

Yang H, Zhang C, Turkez H, ..., Boren J, Mardinoglu A

Nat Metab 5 (5) 760-761 [2023-05-00; online 2023-05-11]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase.

Battisti UM, Monjas L, Akladios F, ..., Mardinoğlu A, Grøtli M

Pharmaceuticals (Basel, Switzerland) 16 (5) - [2023-04-28; online 2023-04-28]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase.

Battisti UM, Gao C, Akladios F, ..., Mardinoglu A, Grøtli M

Nutrients 15 (3) - [2023-01-22; online 2023-01-22]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase.

Battisti UM, Gao C, Nilsson O, ..., Mardinoglu A, Grøtli M

Chembiochem 24 (1) e202200339 [2023-01-03; online 2022-11-09]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet.

Yang H, Mayneris-Perxachs J, Boqué N, ..., Mardinoglu A, Caimari A

Biomedicines 9 (10) - [2021-10-11; online 2021-10-11]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.

Zeybel M, Altay O, Arif M, ..., Borén J, Mardinoglu A

Mol Syst Biol 17 (10) e10459 [2021-10-00; online 2021-10-26]

Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow

PubMed DOI Crossref

Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers.

Li X, Kim W, Arif M, ..., Zhang C, Mardinoglu A

Cancers (Basel) 13 (2) - [2021-01-19; online 2021-01-19]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

A systems biology approach for studying neurodegenerative diseases.

Lam S, Bayraktar A, Zhang C, ..., Uhlen M, Mardinoglu A

Drug Discov. Today 25 (7) 1146-1159 [2020-07-00; online 2020-05-19]

Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow

PubMed DOI Crossref

The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.

Zhang C, Bjornson E, Arif M, ..., Borén J, Mardinoglu A

Mol Syst Biol 16 (4) e9495 [2020-04-00; online 2020-04-28]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia.

Klevstig M, Arif M, Mannila M, ..., Ehrenborg E, Borén J

J. Mol. Cell. Cardiol. 137 (-) 1-8 [2019-12-00; online 2019-09-15]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Systems biology perspective for studying the gut microbiota in human physiology and liver diseases.

Altay O, Nielsen J, Uhlen M, Boren J, Mardinoglu A

EBioMedicine 49 (-) 364-373 [2019-11-00; online 2019-10-18]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.

Liu Z, Zhang C, Lee S, ..., Boren J, Mardinoglu A

Metab. Eng. 52 (-) 263-272 [2019-03-00; online 2019-01-04]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.

Benfeitas R, Bidkhori G, Mukhopadhyay B, ..., Kunos G, Mardinoglu A

EBioMedicine 40 (-) 471-487 [2019-02-00; online 2018-12-31]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.

Håversen L, Sundelin JP, Mardinoglu A, ..., Levin M, Borén J

Sci Rep 8 (1) 16973 [2018-11-19; online 2018-11-19]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

Lovric A, Granér M, Bjornson E, ..., Mardinoglu A, Boren J

Sci Rep 8 (1) 14200 [2018-09-21; online 2018-09-21]

Adil Mardinoglu SciLifeLab Fellow

PubMed DOI Crossref

Systems biology in hepatology: approaches and applications.

Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J

Nat Rev Gastroenterol Hepatol 15 (6) 365-377 [2018-06-00; online 2018-04-25]

Adil Mardinoglu Affiliated researcher SciLifeLab Fellow

PubMed DOI Crossref

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

Mardinoglu A, Wu H, Bjornson E, ..., Taskinen MR, Borén J

Cell Metabolism 27 (3) 559-571.e5 [2018-03-00; online 2018-03-00]

Adil Mardinoglu Affiliated researcher SciLifeLab Fellow

PubMed DOI Crossref

Network analyses identify liver-specific targets for treating liver diseases.

Lee S, Zhang C, Liu Z, ..., Boren J, Mardinoglu A

Mol Syst Biol 13 (8) 938 [2017-08-21; online 2017-08-21]

Adil Mardinoglu Affiliated researcher SciLifeLab Fellow Simon Elsässer

PubMed DOI Crossref

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.

Chaudhari A, Håversen L, Mobini R, ..., Perkins R, Borén J

Biochim. Biophys. Acta 1861 (11) 1643-1651 [2016-11-00; online 2016-07-27]

Adil Mardinoglu SciLifeLab Fellow