EOMES-positive CD4

Chemin K, Ramsköld D, Diaz-Gallo LM, Herrath J, Houtman M, Tandre K, Rönnblom L, Catrina A, Malmström V

Eur. J. Immunol. 48 (4) 655-669 [2018-04-00; online 2018-02-28]

The presence of the PTPN22 risk allele (1858T) is associated with several autoimmune diseases including rheumatoid arthritis (RA). Despite a number of studies exploring the function of PTPN22 in T cells, the exact impact of the PTPN22 risk allele on T-cell function in humans is still unclear. In this study, using RNA sequencing, we show that, upon TCR-activation, naïve human CD4

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PubMed 29388193

DOI 10.1002/eji.201747296

Crossref 10.1002/eji.201747296