TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells.

Fasching L, Kapopoulou A, Sachdeva R, Petri R, Jönsson ME, Männe C, Turelli P, Jern P, Cammas F, Trono D, Jakobsson J

Cell Reports 10 (1) 20-28 [2015-01-06; online 2014-12-24]

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain.

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PubMed 25543143

DOI 10.1016/j.celrep.2014.12.004

Crossref 10.1016/j.celrep.2014.12.004

GEO GSE45930

mid EMS63292

S2211-1247(14)01015-8

pmc PMC4434221