Rapid and Efficient Conversion of (11) CO2 to (11) CO through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations.

Nordeman P, Friis SD, Andersen TL, Audrain H, Larhed M, Skrydstrup T, Antoni G

Chemistry 21 (49) 17601-17604 [2015-12-01; online 2015-10-23]

Herein, we present a new rapid, efficient, and low-cost radiosynthetic protocol for the conversion of (11) CO2 to (11) CO and its subsequent application in Pd-mediated reactions of importance for PET applications. This room-temperature methodology, using readily available chemical reagents, is carried out in simple glass vials, thus eliminating the need for expensive and specialized high-temperature equipment to access (11) CO. With this fast and near-quantitative conversion of (11) CO2 into (11) CO, aryl and heteroaryl iodides were easily converted into a broad selection of biologically active amides in radiochemical yields ranging from 29-84‚ÄČ%.

Affiliated researcher

PubMed 26492852

DOI 10.1002/chem.201503262

Crossref 10.1002/chem.201503262

Publications 9.5.0