Nat Commun

Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.

Papakyriacou I, Kutkaite G, Rúbies Bedós M, ..., Menden MP, Mao Y

Nat Commun 15 (1) 3581 [2024-04-27; online 2024-04-27]

SciLifeLab Fellow Yumeng Mao

The heat shock protein LarA activates the Lon protease in response to proteotoxic stress.

Omnus DJ, Fink MJ, Kallazhi A, ..., Landreh M, Jonas K

Nat Commun 14 (1) 7636 [2023-11-22; online 2023-11-22]

Kristina Jonas SciLifeLab Fellow

NIPMAP: niche-phenotype mapping of multiplex histology data by community ecology.

El Marrahi A, Lipreri F, Kang Z, ..., Alber D, Hausser J

Nat Commun 14 (1) 7182 [2023-11-07; online 2023-11-07]

Jean Hausser SciLifeLab Fellow

PRO-IP-seq tracks molecular modifications of engaged Pol II complexes at nucleotide resolution.

Vihervaara A, Versluis P, Himanen SV, Lis JT

Nat Commun 14 (1) 7039 [2023-11-03; online 2023-11-03]

Anniina Vihervaara SciLifeLab Fellow

Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation.

Jin H, Zhang C, Zwahlen M, ..., Uhlén M, Mardinoglu A

Nat Commun 14 (1) 5417 [2023-09-05; online 2023-09-05]

Adil Mardinoglu SciLifeLab Fellow

Next generation pan-cancer blood proteome profiling using proximity extension assay.

Álvez MB, Edfors F, von Feilitzen K, ..., Fagerberg L, Uhlén M

Nat Commun 14 (1) 4308 [2023-07-18; online 2023-07-18]

Adil Mardinoglu SciLifeLab Fellow

Establishing mammalian GLUT kinetics and lipid composition influences in a reconstituted-liposome system.

Suades A, Qureshi A, McComas SE, ..., Carlsson J, Drew D

Nat Commun 14 (1) 4070 [2023-07-10; online 2023-07-10]

Jens Carlsson SciLifeLab Fellow

MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms.

Erdem C, Gross SM, Heiser LM, Birtwistle MR

Nat Commun 14 (1) 3991 [2023-07-06; online 2023-07-06]

Cemal Erdem DDLS Fellow

Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics.

Jun SH, Toosi H, Mold J, ..., Roth A, Lagergren J

Nat Commun 14 (1) 982 [2023-02-22; online 2023-02-22]

Camilla Engblom SciLifeLab Fellow

Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.

Li B, Zeis P, Zhang Y, ..., Steinmetz LM, Pelechano V

Nat Commun 14 (1) 910 [2023-02-17; online 2023-02-17]

Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.

Leng H, Zhang H, Li L, ..., Simon AK, Horwood NJ

Nat Commun 13 (1) 7868 [2022-12-22; online 2022-12-22]

Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction.

Olsson H, Kartasalo K, Mulliqi N, ..., Spjuth O, Eklund M

Nat Commun 13 (1) 7761 [2022-12-15; online 2022-12-15]

Kimmo Kartasalo

CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.

de Thonel A, Ahlskog JK, Daupin K, ..., Sistonen L, Mezger V

Nat Commun 13 (1) 7002 [2022-11-16; online 2022-11-16]

Anniina Vihervaara SciLifeLab Fellow

Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores.

Jespersen N, Ehrenbolger K, Winiger RR, ..., Vossbrinck CR, Barandun J

Nat Commun 13 (1) 6962 [2022-11-15; online 2022-11-15]

Jonas Barandun SciLifeLab Fellow

FRET-FISH probes chromatin compaction at individual genomic loci in single cells.

Mota A, Berezicki S, Wernersson E, ..., Crosetto N, Bienko M

Nat Commun 13 (1) 6680 [2022-11-05; online 2022-11-05]

Magda Bienko

The origin and evolution of open habitats in North America inferred by Bayesian deep learning models.

Andermann T, Strömberg CAE, Antonelli A, Silvestro D

Nat Commun 13 (1) 4833 [2022-08-17; online 2022-08-17]

DDLS Fellow Tobias Andermann

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.

Hansen JY, Shafiei G, Vogel JW, ..., Dagher A, Misic B

Nat Commun 13 (1) 4682 [2022-08-10; online 2022-08-10]

DDLS Fellow Jacob W Vogel

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.

Chi G, Liang Q, Sridhar A, ..., Covarrubias M, Dürr KL

Nat Commun 13 (1) 4087 [2022-07-15; online 2022-07-15]

Lucie Delemotte SciLifeLab Fellow

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling.

Erdem C, Mutsuddy A, Bensman EM, ..., Feltus FA, Birtwistle MR

Nat Commun 13 (1) 3555 [2022-06-21; online 2022-06-21]

Cemal Erdem DDLS Fellow

T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.

Céspedes PF, Jainarayanan A, Fernández-Messina L, ..., Sánchez-Madrid F, Dustin ML

Nat Commun 13 (1) 3460 [2022-06-16; online 2022-06-16]

Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.

Crowe-McAuliffe C, Murina V, Turnbull KJ, ..., Wilson DN, Hauryliuk V

Nat Commun 13 (1) 1860 [2022-04-06; online 2022-04-06]

Norway spruce postglacial recolonization of Fennoscandia.

Nota K, Klaminder J, Milesi P, ..., Suyama Y, Parducci L

Nat Commun 13 (1) 1333 [2022-03-14; online 2022-03-14]

Pascal Milesi SciLifeLab Fellow

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.

Garcia Morato J, Hans F, von Zweydorf F, ..., Neumann M, Kahle PJ

Nat Commun 13 (1) 1223 [2022-03-09; online 2022-03-09]

SciLifeLab Fellow Simon Elsässer

SM-Omics is an automated platform for high-throughput spatial multi-omics.

Vickovic S, Lötstedt B, Klughammer J, ..., Rozenblatt-Rosen O, Regev A

Nat Commun 13 (1) 795 [2022-02-10; online 2022-02-10]

Sanja Vickovic SciLifeLab Fellow

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.

Hanke L, Das H, Sheward DJ, ..., Murrell B, McInerney GM

Nat Commun 13 (1) 155 [2022-01-10; online 2022-01-10]

Functional dissection of inherited non-coding variation influencing multiple myeloma risk.

Ajore R, Niroula A, Pertesi M, ..., Houlston R, Nilsson B

Nat Commun 13 (1) 151 [2022-01-10; online 2022-01-10]

Abhishek Niroula DDLS Fellow

Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae.

Schön ME, Zlatogursky VV, Singh RP, ..., Wideman JG, Burki F

Nat Commun 12 (1) 6651 [2021-11-17; online 2021-11-17]

Fabien Burki SciLifeLab Fellow

DOI Crossref

A method for intuitively extracting macromolecular dynamics from structural disorder

Pearce NM, Gros P

Nat Commun 12 (1) - [2021-09-17; online 2021-09-17]

DDLS Fellow Nicholas Pearce

COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance.

Simonetti M, Zhang N, Harbers L, ..., Ghisetti V, Crosetto N

Nat Commun 12 (1) 3903 [2021-06-23; online 2021-06-23]

Magda Bienko

Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.

Roxhed N, Bendes A, Dale M, ..., Fredolini C, Schwenk JM

Nat Commun 12 (1) 3695 [2021-06-17; online 2021-06-17]

SciLifeLab Fellow Simon Elsässer

A molecular timescale for eukaryote evolution with implications for the origin of red algal-derived plastids.

Strassert JFH, Irisarri I, Williams TA, Burki F

Nat Commun 12 (1) 1879 [2021-03-25; online 2021-03-25]

Fabien Burki SciLifeLab Fellow

Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing.

Mattsson J, Ekdahl L, Junghus F, ..., Teige I, Nilsson B

Nat Commun 12 (1) 1277 [2021-02-24; online 2021-02-24]

Abhishek Niroula DDLS Fellow

Error correction enables use of Oxford Nanopore technology for reference-free transcriptome analysis.

Sahlin K, Medvedev P

Nat Commun 12 (1) 2 [2021-01-04; online 2021-01-04]

Kristoffer Sahlin SciLifeLab Fellow

Distinct pre-initiation steps in human mitochondrial translation

Khawaja A, Itoh Y, Remes C, ..., Amunts A, Rorbach J

Nat Commun 11 (1) - [2020-12-00; online 2020-06-10]

Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi

Itoh Y, Naschberger A, Mortezaei N, Herrmann JM, Amunts A

Nat Commun 11 (1) - [2020-12-00; online 2020-10-14]

Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells.

Tarbier M, Mackowiak SD, Frade J, ..., Gallant CJ, Friedländer MR

Nat Commun 11 (1) 5445 [2020-10-28; online 2020-10-28]

Magda Bienko Marc Friedländer SciLifeLab Fellow

Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.

Flygaard RK, Mühleip A, Tobiasson V, Amunts A

Nat Commun 11 (1) 5342 [2020-10-22; online 2020-10-22]

An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.

Navarro C, Lyu J, Katsori AM, Caridha R, Elsässer SJ

Nat Commun 11 (1) 5095 [2020-10-09; online 2020-10-09]

SciLifeLab Fellow Simon Elsässer

Integration of molecular profiles in a longitudinal wellness profiling cohort.

Tebani A, Gummesson A, Zhong W, ..., Uhlen M, Fagerberg L

Nat Commun 11 (1) 4487 [2020-09-08; online 2020-09-08]

Adil Mardinoglu SciLifeLab Fellow

Transcript isoform sequencing reveals widespread promoter-proximal transcriptional termination in Arabidopsis.

Thomas QA, Ard R, Liu J, ..., Pelechano V, Marquardt S

Nat Commun 11 (1) 2589 [2020-05-22; online 2020-05-22]

Pooled CRISPRi screening of the cyanobacterium Synechocystis sp PCC 6803 for enhanced industrial phenotypes.

Yao L, Shabestary K, Björk SM, ..., Jahn M, Hudson EP

Nat Commun 11 (1) 1666 [2020-04-03; online 2020-04-03]

Paul Hudson SciLifeLab Fellow

Regulation of lipid saturation without sensing membrane fluidity.

Ballweg S, Sezgin E, Doktorova M, ..., Hummer G, Ernst R

Nat Commun 11 (1) 756 [2020-02-06; online 2020-02-06]

Abundance and diversity of resistomes differ between healthy human oral cavities and gut.

Carr VR, Witherden EA, Lee S, ..., Gomez-Cabrero D, Moyes DL

Nat Commun 11 (1) 693 [2020-02-04; online 2020-02-04]

Saeed Shoaie SciLifeLab Fellow

A set of monomeric near-infrared fluorescent proteins for multicolor imaging across scales.

Matlashov ME, Shcherbakova DM, Alvelid J, ..., Testa I, Verkhusha VV

Nat Commun 11 (1) 239 [2020-01-13; online 2020-01-13]

Ilaria Testa SciLifeLab Fellow

CUTseq is a versatile method for preparing multiplexed DNA sequencing libraries from low-input samples.

Zhang X, Garnerone S, Simonetti M, ..., Bienko M, Crosetto N

Nat Commun 10 (1) 4732 [2019-10-18; online 2019-10-18]

Magda Bienko SciLifeLab Fellow

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe.

Cardozo Pinto DF, Yang H, Pollak Dorocic I, ..., Smidt MP, Lammel S

Nat Commun 10 (1) 4633 [2019-10-11; online 2019-10-11]

Iskra Pollak Dorocic SciLifeLab Fellow

Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.

Nirwan N, Itoh Y, Singh P, ..., Amunts A, Saikrishnan K

Nat Commun 10 (1) 3058 [2019-07-11; online 2019-07-11]

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks.

Domingo-Prim J, Endara-Coll M, Bonath F, ..., Huertas P, Visa N

Nat Commun 10 (1) 2135 [2019-05-13; online 2019-05-13]

Marc Friedländer SciLifeLab Fellow

Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling.

Sabantsev A, Levendosky RF, Zhuang X, Bowman GD, Deindl S

Nat Commun 10 (1) 1720 [2019-04-12; online 2019-04-12]

SciLifeLab Fellow Sebastian Deindl

iFISH is a publically available resource enabling versatile DNA FISH to study genome architecture.

Gelali E, Girelli G, Matsumoto M, ..., Crosetto N, Bienko M

Nat Commun 10 (1) 1636 [2019-04-09; online 2019-04-09]

Magda Bienko SciLifeLab Fellow

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.

Wright SC, Kozielewicz P, Kowalski-Jahn M, ..., Carlsson J, Schulte G

Nat Commun 10 (1) 667 [2019-02-08; online 2019-02-08]

Jens Carlsson SciLifeLab Fellow

Smart scanning for low-illumination and fast RESOLFT nanoscopy in vivo.

Dreier J, Castello M, Coceano G, ..., Vicidomini G, Testa I

Nat Commun 10 (1) 556 [2019-02-01; online 2019-02-01]

Ilaria Testa SciLifeLab Fellow

Deciphering highly similar multigene family transcripts from Iso-Seq data with IsoCon.

Sahlin K, Tomaszkiewicz M, Makova KD, Medvedev P

Nat Commun 9 (1) 4601 [2018-11-02; online 2018-11-02]

Kristoffer Sahlin SciLifeLab Fellow

Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements.

Pärnänen K, Karkman A, Hultman J, ..., Satokari R, Virta M

Nat Commun 9 (1) 3891 [2018-09-24; online 2018-09-24]

DDLS Fellow Johan Bengtsson-Palme

Enhanced photon collection enables four dimensional fluorescence nanoscopy of living systems.

Masullo LA, Bodén A, Pennacchietti F, ..., Ratz M, Testa I

Nat Commun 9 (1) 3281 [2018-08-16; online 2018-08-16]

Affiliated researcher Ilaria Testa SciLifeLab Fellow

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

van Setten J, Brody JA, Jamshidi Y, ..., Arking DE, Sotoodehnia N

Nat Commun 9 (1) 2904 [2018-07-25; online 2018-07-25]

Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events.

Honkura N, Richards M, Laviña B, ..., Betsholtz C, Claesson-Welsh L

Nat Commun 9 (1) 2746 [2018-07-16; online 2018-07-16]

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity.

Berglund E, Maaskola J, Schultz N, ..., Helleday T, Lundeberg J

Nat Commun 9 (1) 2419 [2018-06-20; online 2018-06-20]

Affiliated researcher Sanja Vickovic SciLifeLab Fellow

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S

Nat Commun 9 (1) 2071 [2018-05-22; online 2018-05-22]

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

Wahlgren WY, Dunevall E, North RA, ..., Ramaswamy S, Friemann R

Nat Commun 9 (1) 1753 [2018-05-01; online 2018-05-01]

DDLS Fellow Johan Bengtsson-Palme

The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression.

Ali M, Ajore R, Wihlborg AK, ..., Weinhold N, Nilsson B

Nat Commun 9 (1) 1649 [2018-04-25; online 2018-04-25]

Abhishek Niroula DDLS Fellow

Repeated evolution of self-compatibility for reproductive assurance.

Nieuwenhuis BPS, Tusso S, Bjerling P, ..., Wolf JBW, Immler S

Nat Commun 9 (1) 1639 [2018-04-24; online 2018-04-24]

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.

Södersten E, Toskas K, Rraklli V, ..., Perlmann T, Holmberg J

Nat Commun 9 (1) 1226 [2018-03-26; online 2018-03-26]

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S

Nat Commun 9 (1) 1107 [2018-03-16; online 2018-03-16]

Affiliated researcher SciLifeLab Fellow Vicent Pelechano

Wing bone geometry reveals active flight in Archaeopteryx.

Voeten DFAE, Cubo J, de Margerie E, ..., Tafforeau P, Sanchez S

Nat Commun 9 (1) 923 [2018-03-13; online 2018-03-13]

Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow.

Zhu Y, Orre LM, Johansson HJ, ..., Branca RMM, Lehtiö J

Nat Commun 9 (1) 903 [2018-03-02; online 2018-03-02]

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging.

Franco I, Johansson A, Olsson K, ..., Fischer H, Eriksson M

Nat Commun 9 (1) 800 [2018-02-23; online 2018-02-23]

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T

Nat Commun 9 (1) 250 [2018-01-17; online 2018-01-17]

Intelligent image-based in situ single-cell isolation.

Brasko C, Smith K, Molnar C, ..., Tamas G, Horvath P

Nat Commun 9 (1) 226 [2018-01-15; online 2018-01-15]

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state.

Chen G, Abelein A, Nilsson HE, ..., Fisahn A, Johansson J

Nat Commun 8 (1) 2081 [2017-12-12; online 2017-12-12]

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma.

Lauss M, Donia M, Harbst K, ..., Svane IM, Jönsson G

Nat Commun 8 (1) 1738 [2017-11-23; online 2017-11-23]

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.

Carreras-Puigvert J, Zitnik M, Jemth AS, ..., Zupan B, Helleday T

Nat Commun 8 (1) 1541 [2017-11-16; online 2017-11-16]

The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity.

Ernst C, Odom DT, Kutter C

Nat Commun 8 (1) 1411 [2017-11-10; online 2017-11-10]

Affiliated researcher Claudia Kutter SciLifeLab Fellow

Efficient protein production by yeast requires global tuning of metabolism.

Huang M, Bao J, Hallström BM, Petranovic D, Nielsen J

Nat Commun 8 (1) 1131 [2017-10-25; online 2017-10-25]

Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon.

Hennell James R, Caceres EF, Escasinas A, ..., Ettema TJG, Robinson NP

Nat Commun 8 (1) 1120 [2017-10-24; online 2017-10-24]

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.

Noh HJ, Tang R, Flannick J, ..., Karlsson EK, Lindblad-Toh K

Nat Commun 8 (1) 774 [2017-10-17; online 2017-10-17]

The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus.

Matzov D, Aibara S, Basu A, ..., Amunts A, Yonath AE

Nat Commun 8 (1) 723 [2017-09-28; online 2017-09-28]

Affiliated researcher Alexey Amunts SciLifeLab Fellow

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.

Shen X, Klarić L, Sharapov S, ..., Lauc G, Aulchenko YS

Nat Commun 8 (1) 447 [2017-09-06; online 2017-09-06]

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.

Asim M, Tarish F, Zecchini HI, ..., Neal D, Helleday T

Nat Commun 8 (1) 374 [2017-08-29; online 2017-08-29]

Transcriptional response to stress is pre-wired by promoter and enhancer architecture.

Vihervaara A, Mahat DB, Guertin MJ, ..., Lis JT, Sistonen L

Nat Commun 8 (1) 255 [2017-08-15; online 2017-08-15]

Anniina Vihervaara SciLifeLab Fellow

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.

Petersen J, Wright SC, Rodríguez D, ..., Carlsson J, Schulte G

Nat Commun 8 (1) 226 [2017-08-09; online 2017-08-09]

Affiliated researcher Jens Carlsson SciLifeLab Fellow

De novo active sites for resurrected Precambrian enzymes.

Risso VA, Martinez-Rodriguez S, Candel AM, ..., Gavira JA, Sanchez-Ruiz JM

Nat Commun 8 (-) 16113 [2017-07-18; online 2017-07-18]

Transancestral mapping and genetic load in systemic lupus erythematosus.

Langefeld CD, Ainsworth HC, Cunninghame Graham DS, ..., Gaffney PM, Vyse TJ

Nat Commun 8 (-) 16021 [2017-07-17; online 2017-07-17]

The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization.

Alam MT, Olin-Sandoval V, Stincone A, ..., Luisi BF, Ralser M

Nat Commun 8 (-) 16018 [2017-07-10; online 2017-07-10]

Aleksej Zelezniak SciLifeLab Fellow

A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome.

Diepold A, Sezgin E, Huseyin M, ..., Eggeling C, Armitage JP

Nat Commun 8 (-) 15940 [2017-06-27; online 2017-06-27]

Insufficient antibody validation challenges oestrogen receptor beta research.

Andersson S, Sundberg M, Pristovsek N, ..., Williams C, Asplund A

Nat Commun 8 (-) 15840 [2017-06-15; online 2017-06-15]

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Nolte IM, Munoz ML, Tragante V, ..., Snieder H, de Geus EJC

Nat Commun 8 (-) 15805 [2017-06-14; online 2017-06-14]

Expression of CD226 is associated to but not required for NK cell education.

Wagner AK, Kadri N, Snäll J, ..., Kärre K, Chambers BJ

Nat Commun 8 (1) 15627 [2017-05-31; online 2017-05-31]

A damaged genome's transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks.

Iannelli F, Galbiati A, Capozzo I, ..., Carninci P, d'Adda di Fagagna F

Nat Commun 8 (-) 15656 [2017-05-31; online 2017-05-31]

Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals.

Yu T, Zhou YJ, Wenning L, ..., Nielsen J, David F

Nat Commun 8 (-) 15587 [2017-05-26; online 2017-05-26]

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks.

Yan WX, Mirzazadeh R, Garnerone S, ..., Bienko M, Crosetto N

Nat Commun 8 (1) 15058 [2017-05-12; online 2017-05-12]

Affiliated researcher Magda Bienko SciLifeLab Fellow

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

Justice AE, Winkler TW, Feitosa MF, ..., North KE, Cupples LA

Nat Commun 8 (-) 14977 [2017-04-26; online 2017-04-26]

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.

Pearce NM, Krojer T, Bradley AR, ..., Deane CM, von Delft F

Nat Commun 8 (-) 15123 [2017-04-24; online 2017-04-24]

DDLS Fellow Nicholas Pearce

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Schütte M, Risch T, Abdavi-Azar N, ..., Lehrach H, Yaspo ML

Nat Commun 8 (-) 14262 [2017-02-10; online 2017-02-10]

Molecular composition of organic matter controls methylmercury formation in boreal lakes.

Bravo AG, Bouchet S, Tolu J, ..., Mateos-Rivera A, Bertilsson S

Nat Commun 8 (-) 14255 [2017-02-09; online 2017-02-09]

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Law PJ, Berndt SI, Speedy HE, ..., Houlston R, Slager S

Nat Commun 8 (-) 14175 [2017-02-06; online 2017-02-06]

Novel genetic loci associated with hippocampal volume.

Hibar DP, Adams HHH, Jahanshad N, ..., Thompson PM, Ikram MA

Nat Commun 8 (-) 13624 [2017-01-18; online 2017-01-18]

Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy.

Kühnemund M, Wei Q, Darai E, ..., Ozcan A, Nilsson M

Nat Commun 8 (-) 13913 [2017-01-17; online 2017-01-17]

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity.

Corcoran MM, Phad GE, Vázquez Bernat , ..., Martin M, Karlsson Hedestam GB

Nat Commun 7 (-) 13642 [2016-12-20; online 2016-12-20]

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.

Rasmussen RD, Gajjar MK, Tuckova L, ..., Frederiksen MH, Hamerlik P

Nat Commun 7 (-) 13398 [2016-11-15; online 2016-11-15]

Evolution of heterogeneous genome differentiation across multiple contact zones in a crow species complex.

Vijay N, Bossu CM, Poelstra JW, ..., Kryukov AP, Wolf JB

Nat Commun 7 (-) 13195 [2016-10-31; online 2016-10-31]

Reconstructing a hydrogen-driven microbial metabolic network in Opalinus Clay rock.

Bagnoud A, Chourey K, Hettich RL, ..., Schwyn B, Bernier-Latmani R

Nat Commun 7 (-) 12770 [2016-10-14; online 2016-10-14]

Massive and parallel expression profiling using microarrayed single-cell sequencing.

Vickovic S, Ståhl PL, Salmén F, ..., Frisén J, Lundeberg J

Nat Commun 7 (1) 13182 [2016-10-14; online 2016-10-14]

Affiliated researcher Magda Bienko Sanja Vickovic SciLifeLab Fellow

A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection.

López-Saavedra A, Gómez-Cabello D, Domínguez-Sánchez MS, ..., Bartek J, Huertas P

Nat Commun 7 (-) 12364 [2016-08-09; online 2016-08-09]

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.

Gerling M, Büller NV, Kirn LM, ..., van den Brink GR, Toftgård R

Nat Commun 7 (-) 12321 [2016-08-05; online 2016-08-05]

Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture.

Pijuan-Galitó S, Tamm C, Schuster J, ..., Merry CL, Annerén C

Nat Commun 7 (-) 12170 [2016-07-13; online 2016-07-13]

UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly.

Hunziker M, Barandun J, Petfalski E, ..., Tollervey D, Klinge S

Nat Commun 7 (-) 12090 [2016-06-29; online 2016-06-29]

Jonas Barandun SciLifeLab Fellow

Genome-culture coevolution promotes rapid divergence of killer whale ecotypes.

Foote AD, Vijay N, Ávila-Arcos MC, ..., Gilbert MT, Wolf JB

Nat Commun 7 (-) 11693 [2016-05-31; online 2016-05-31]

Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories.

Zhou YJ, Buijs NA, Zhu Z, ..., Siewers V, Nielsen J

Nat Commun 7 (-) 11709 [2016-05-25; online 2016-05-25]

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.

Gandin V, Masvidal L, Cargnello M, ..., Larsson O, Topisirovic I

Nat Commun 7 (-) 11127 [2016-04-04; online 2016-04-04]

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, Jafari R, ..., Lundbäck T, Nordlund P

Nat Commun 7 (-) 11040 [2016-03-24; online 2016-03-24]

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

Li X, Padhan N, Sjöström EO, ..., Jansson L, Claesson-Welsh L

Nat Commun 7 (-) 11017 [2016-03-23; online 2016-03-23]

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Lu Y, Day FR, Gustafsson S, ..., Kilpeläinen TO, Loos RJ

Nat Commun 7 (-) 10495 [2016-02-01; online 2016-02-01]

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Kilpeläinen TO, Carli JF, Skowronski AA, ..., Leibel RL, Loos RJ

Nat Commun 7 (-) 10494 [2016-02-01; online 2016-02-01]

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Pattaro C, Teumer A, Gorski M, ..., Kao WH, Fox CS

Nat Commun 7 (-) 10023 [2016-01-21; online 2016-01-21]

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Soler Artigas M, Wain LV, Miller S, ..., Hall IP, Tobin MD

Nat Commun 6 (-) 8658 [2015-12-04; online 2015-12-04]

The alternative splicing factor Nova2 regulates vascular development and lumen formation.

Giampietro C, Deflorian G, Gallo S, ..., Dejana E, Ghigna C

Nat Commun 6 (-) 8479 [2015-10-08; online 2015-10-08]

Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development.

Töhönen V, Katayama S, Vesterlund L, ..., Hovatta O, Kere J

Nat Commun 6 (-) 8207 [2015-09-11; online 2015-09-11]

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.

Stödberg T, McTague A, Ruiz AJ, ..., Wedell A, Kurian MA

Nat Commun 6 (-) 8038 [2015-09-03; online 2015-09-03]

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.

Carter M, Jemth AS, Hagenkort A, ..., Helleday T, Stenmark P

Nat Commun 6 (-) 7871 [2015-08-04; online 2015-08-04]

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures.

Mondal T, Subhash S, Vaid R, ..., Gorab E, Kanduri C

Nat Commun 6 (-) 7743 [2015-07-24; online 2015-07-24]

Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol.

Hacke M, Björkholm P, Hellwig A, ..., Wieland F, Ernst AM

Nat Commun 6 (-) 7688 [2015-07-09; online 2015-07-09]

Proximity-dependent initiation of hybridization chain reaction.

Koos B, Cane G, Grannas K, ..., Kamali-Moghaddam M, Söderberg O

Nat Commun 6 (-) 7294 [2015-06-12; online 2015-06-12]

Phasing of single DNA molecules by massively parallel barcoding.

Borgström E, Redin D, Lundin S, ..., Andersson AF, Ahmadian A

Nat Commun 6 (-) 7173 [2015-06-09; online 2015-06-09]

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

Allum F, Shao X, Guénard F, ..., Pastinen T, Grundberg E

Nat Commun 6 (-) 7211 [2015-05-29; online 2015-05-29]

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.

Swaminathan B, Thorleifsson G, Jöud M, ..., Thorsteinsdóttir U, Nilsson B

Nat Commun 6 (1) 7213 [2015-05-26; online 2015-05-26]

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.

Jäger R, Migliorini G, Henrion M, ..., Fletcher O, Houlston RS

Nat Commun 6 (-) 6178 [2015-02-19; online 2015-02-19]

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Wessel J, Chu AY, Willems SM, ..., Scott RA, Goodarzi MO

Nat Commun 6 (-) 5897 [2015-01-29; online 2015-01-29]

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.

Mengelbier LH, Karlsson J, Lindgren D, ..., Mayrhofer M, Gisselsson D

Nat Commun 6 (-) 6125 [2015-01-27; online 2015-01-27]

Biological interpretation of genome-wide association studies using predicted gene functions.

Pers TH, Karjalainen JM, Chan Y, ..., Hirschhorn JN, Franke L

Nat Commun 6 (-) 5890 [2015-01-19; online 2015-01-19]

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

Mardinoglu A, Agren R, Kampf C, ..., Uhlen M, Nielsen J

Nat Commun 5 (1) - [2014-12-00; online 2014-01-14]

Adil Mardinoglu Affiliated researcher SciLifeLab Fellow

Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells.

Honigmann A, Mueller V, Ta H, ..., Hell SW, Eggeling C

Nat Commun 5 (-) 5412 [2014-11-20; online 2014-11-20]

Spontaneous transmembrane helix insertion thermodynamically mimics translocon-guided insertion.

Ulmschneider MB, Ulmschneider JP, Schiller N, ..., von Heijne G, White SH

Nat Commun 5 (-) 4863 [2014-09-10; online 2014-09-10]

The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.

Ahola V, Lehtonen R, Somervuo P, ..., Frilander MJ, Hanski I

Nat Commun 5 (-) 4737 [2014-09-05; online 2014-09-05]

Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.

Enroth S, Johansson A, Enroth SB, Gyllensten U

Nat Commun 5 (-) 4684 [2014-08-22; online 2014-08-22]

Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.

Bassett AR, Azzam G, Wheatley L, ..., Sauka-Spengler T, Fulga TA

Nat Commun 5 (-) 4640 [2014-08-19; online 2014-08-19]

Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster.

Jeibmann A, Eikmeier K, Linge A, ..., Paulus W, Hasselblatt M

Nat Commun 5 (-) 4005 [2014-06-03; online 2014-06-03]

Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.

Kronqvist N, Otikovs M, Chmyrov V, ..., Jaudzems K, Johansson J

Nat Commun 5 (-) 3254 [2014-02-11; online 2014-02-11]

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.

Rodin S, Antonsson L, Niaudet C, ..., Hovatta O, Tryggvason K

Nat Commun 5 (-) 3195 [2014-01-28; online 2014-01-28]

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.

Nilsson R, Jain M, Madhusudhan N, ..., Asplund A, Mootha VK

Nat Commun 5 (-) 3128 [2014-01-24; online 2014-01-24]

Dynamic heterogeneity controls diffusion and viscosity near biological interfaces.

Pronk S, Lindahl E, Kasson PM

Nat Commun 5 (-) 3034 [2014-01-09; online 2014-01-09]

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.

Johansson HJ, Sanchez BC, Mundt F, ..., Linderholm BK, Lehtiö J

Nat Commun 4 (-) 2175 [2013-07-23; online 2013-07-23]

The genomics of selection in dogs and the parallel evolution between dogs and humans.

Wang GD, Zhai W, Yang HC, ..., Wu CI, Zhang YP

Nat Commun 4 (-) 1860 [2013-05-16; online 2013-05-16]

Transcription factor binding kinetics constrain noise suppression via negative feedback.

Grönlund A, Lötstedt P, Elf J

Nat Commun 4 (-) 1864 [2013-05-16; online 2013-05-16]

High-throughput hyperdimensional vertebrate phenotyping.

Pardo-Martin C, Allalou A, Medina J, ..., Wählby C, Fatih Yanik M

Nat Commun 4 (-) 1467 [2013-02-14; online 2013-02-14]

Distinct modes of DNA accessibility in plant chromatin.

Shu H, Wildhaber T, Siretskiy A, Gruissem W, Hennig L

Nat Commun 3 (-) 1281 [2012-12-13; online 2012-12-13]

Structures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathway.

Özcelik D, Barandun J, Schmitz N, ..., Ban N, Weber-Ban E

Nat Commun 3 (-) 1014 [2012-08-23; online 2012-08-23]

Jonas Barandun SciLifeLab Fellow

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

Arabi A, Ullah K, Branca RM, ..., Lehtiö J, Sangfelt O

Nat Commun 3 (-) 976 [2012-08-07; online 2012-08-07]

Delay-induced anomalous fluctuations in intracellular regulation.

Grönlund A, Lötstedt P, Elf J

Nat Commun 2 (-) 419 [2011-08-09; online 2011-08-09]