Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro.
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Kootala S, Zhang Y, Ghalib S, Tolmachev V, Hilborn J, Ossipov DA
Biomater Sci 4 (2) 250-254 [2016-02-00; online 2015-11-28]
An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.
PubMed 26610690
DOI 10.1039/c5bm00355e
Crossref 10.1039/c5bm00355e