Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro.

Kootala S, Zhang Y, Ghalib S, Tolmachev V, Hilborn J, Ossipov DA

Biomater Sci 4 (2) 250-254 [2016-02-00; online 2015-11-28]

An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.

Affiliated researcher

PubMed 26610690

DOI 10.1039/c5bm00355e

Crossref 10.1039/c5bm00355e