Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel

Fernández-Mariño AI, Harpole TJ, Oelstrom K, Delemotte L, Chanda B

Nat Struct Mol Biol 25 (4) 320-326 [2018-04-00; online 2018-03-26]

Membrane potential regulates the activity of voltage-dependent ion channels via specialized voltage-sensing modules, but the mechanisms involved in coupling voltage-sensor movement to pore opening remain unclear owing to a lack of resting state structures and robust methods to identify allosteric pathways. Here, using a newly developed interaction-energy analysis, we probe the interfaces of the voltage-sensing and pore modules in the Drosophila Shaker K

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PubMed 29581567

DOI 10.1038/s41594-018-0047-3

Crossref 10.1038/s41594-018-0047-3