Genome-wide probabilistic reconciliation analysis across vertebrates.

Mahmudi O, Sjöstrand J, Sennblad B, Lagergren J

BMC Bioinformatics 14 Suppl 15 (-) S10 [2013-10-15; online 2013-10-15]

Gene duplication is considered to be a major driving force in evolution that enables the genome of a species to acquire new functions. A reconciliation--a mapping of gene tree vertices to the edges or vertices of a species tree--explains where gene duplications have occurred on the species tree. In this study, we sample reconciliations from a posterior over reconciliations, gene trees, edge lengths and other parameters, given a species tree and gene sequences. We employ a Bayesian analysis tool, based on the probabilistic model DLRS that integrates gene duplication, gene loss and sequence evolution under a relaxed molecular clock for substitution rates, to obtain this posterior.

Affiliated researcher

PubMed 24564421

DOI 10.1186/1471-2105-14-S15-S10

Crossref 10.1186/1471-2105-14-S15-S10

pii: 1471-2105-14-S15-S10
pmc: PMC3852046

Publications 9.5.0