Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

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Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG

Genome Biol. 19 (1) 37 [2018-03-16; online 2018-03-16]

Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21 We now demonstrate that p21 Our results signify the importance of mutational signatures as guides to disclose the repair history leading to genomic instability. We unveil how chronic p21

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PubMed 29548335

DOI 10.1186/s13059-018-1401-9

Crossref 10.1186/s13059-018-1401-9

pii: 10.1186/s13059-018-1401-9
pmc: PMC5857109