Opposing consequences of signaling through EGF family members: Escape from CTLs could be a bait for NK cells.

Kiessling R, Okita R, Mougiakakos D, Mao Y, Sarhan D, Wennerberg E, Seliger B, Lundqvist A, Mimura K, Kono K

Oncoimmunology 1 (7) 1200-1201 [2012-10-01; online 2012-11-22]

Oncogenes have been traditionally viewed as molecular drivers for tumor growth and survival. Recent evidence indicates that oncogenes may facilitate the escape of malignant cells from immune recognition and elimination. In this article, we discuss the implications of the overexpression of epidermal growth factor receptor (EGFR) family members on immune escape of tumors and immunotherapy.

SciLifeLab Fellow

Yumeng Mao

PubMed 23170279

DOI 10.4161/onci.20685

Crossref 10.4161/onci.20685

pmc: PMC3494645
pii: 2012ONCOIMM0145

Publications 9.5.0