Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma.

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Roos L, Sandling JK, Bell CG, Glass D, Mangino M, Spector TD, Deloukas P, Bataille V, Bell JT

J. Invest. Dermatol. 137 (4) 910-920 [2017-04-00; online 2016-12-18]

High nevus count is the strongest risk factor for melanoma, and although gene variants have been discovered for both traits, epigenetic variation is unexplored. We investigated 322 healthy human skin DNA methylomes associated with total body nevi count, incorporating genetic and transcriptomic variation. DNA methylation changes were identified at genes involved in melanocyte biology, such as RAF1 (P = 1.2 × 10

Affiliated researcher

PubMed 27993549

DOI 10.1016/j.jid.2016.11.029

Crossref 10.1016/j.jid.2016.11.029

pii: S0022-202X(16)32787-7
pmc: PMC5754330