Human ROBO1 regulates interaural interaction in auditory pathways.

Lamminmäki S, Massinen S, Nopola-Hemmi J, Kere J, Hari R

J. Neurosci. 32 (3) 966-971 [2012-01-18; online 2012-01-21]

In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.

Affiliated researcher

PubMed 22262894

DOI 10.1523/JNEUROSCI.4007-11.2012

Crossref 10.1523/JNEUROSCI.4007-11.2012

pii: 32/3/966

Publications 7.1.2