Phenotype standardization of angioedema in the head and neck region caused by agents acting on the angiotensin system.
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Wadelius M, Marshall SE, Islander G, Nordang L, Karawajczyk M, Yue QY, Terreehorst I, Baranova EV, Hugosson S, Sköldefors K, Pirmohamed M, Maitland-van der Zee AH, Alfirevic A, Hallberg P, Palmer CN
Clin. Pharmacol. Ther. 96 (4) 477-481 [2014-10-00; online 2014-06-24]
Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.
PubMed 24960520
DOI 10.1038/clpt.2014.138
Crossref 10.1038/clpt.2014.138
pii: clpt2014138
pmc: PMC4172548