Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease.

Wegrzyniak O, Rosestedt M, Eriksson O

Int J Mol Sci 22 (14) - [2021-07-08; online 2021-07-08]

Pathological fibrosis of the liver is a landmark feature in chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Diagnosis and assessment of progress or treatment efficacy today requires biopsy of the liver, which is a challenge in, e.g., longitudinal interventional studies. Molecular imaging techniques such as positron emission tomography (PET) have the potential to enable minimally invasive assessment of liver fibrosis. This review will summarize and discuss the current status of the development of innovative imaging markers for processes relevant for fibrogenesis in liver, e.g., certain immune cells, activated fibroblasts, and collagen depositions.

Olof Eriksson

SciLifeLab Fellow

PubMed 34298967

DOI 10.3390/ijms22147348

Crossref 10.3390/ijms22147348

pmc: PMC8306605
pii: ijms22147348

Publications 9.5.0