Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths.

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Kirik U, Persson H, Levander F, Greiff L, Ohlin M

Front Immunol 8 (-) 1433 [2017-11-13; online 2017-11-13]

B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve, e.g., base substitution, codon insertion and deletion, often in association with an isotype switch. Investigations of antibody evolution define modes whereby particular antibody responses are able to form, and such studies provide insight important for instance for development of efficient vaccines. Antibody evolution is also used

Affiliated researcher

PubMed 29180996

DOI 10.3389/fimmu.2017.01433

Crossref 10.3389/fimmu.2017.01433

pmc: PMC5694033