Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.

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Mateus A, Gordon LJ, Wayne GJ, Almqvist H, Axelsson H, Seashore-Ludlow B, Treyer A, Matsson P, Lundbäck T, West A, Hann MM, Artursson P

Proc. Natl. Acad. Sci. U.S.A. 114 (30) E6231-E6239 [2017-07-25; online 2017-07-12]

Inadequate target exposure is a major cause of high attrition in drug discovery. Here, we show that a label-free method for quantifying the intracellular bioavailability (F

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PubMed 28701380

DOI 10.1073/pnas.1701848114

Crossref 10.1073/pnas.1701848114

pii: 1701848114
pmc: PMC5544291