Unboxing mutations: Connecting mutation types with evolutionary consequences.

Berdan EL, Blanckaert A, Slotte T, Suh A, Westram AM, Fragata I

Mol. Ecol. 30 (12) 2710-2723 [2021-06-00; online 2021-05-19]

A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framework. Here, we propose a research framework that directly utilizes the most important characteristics of mutations, their population genetic effects, to determine their relative evolutionary significance in a given scenario. We review known population genetic effects of different mutation types and show how these may be connected to different evolutionary outcomes. We provide examples of how to implement this framework and pinpoint areas where more data, theory and synthesis are needed. Linking experimental and theoretical approaches to examine different mutation types simultaneously is a critical step towards understanding their evolutionary significance.

SciLifeLab Fellow

Tanja Slotte

PubMed 33955064

DOI 10.1111/mec.15936

Crossref 10.1111/mec.15936

Publications 9.5.0