Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.

Nagaraj AS, Lahtela J, Hemmes A, Pellinen T, Blom S, Devlin JR, Salmenkivi K, Kallioniemi O, Mäyränpää MI, Närhi K, Verschuren EW

Cell Reports 18 (3) 673-684 [2017-01-17; online 2017-01-19]

Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of Kras

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PubMed 28099846

DOI 10.1016/j.celrep.2016.12.059

Crossref 10.1016/j.celrep.2016.12.059

S2211-1247(16)31766-1